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Synthetic method of high-molecular-weight polylactic acid

A high-molecular-weight, synthetic method technology, applied in the field of high-molecular-weight polylactic acid synthesis, can solve the problems of restricting the industrial production and market promotion of polylactic acid biodegradable materials, difficulty in injection molding, and low synthetic molecular weight, etc. Rate and controllability, controllable reaction conditions, effect of increasing molecular mass

Pending Publication Date: 2022-03-22
江苏睿安应用生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In the prior art, most polylactic acid synthesis methods have defects such as low synthetic molecular weight, complex reaction conditions, high production cost, and relatively difficult injection molding, which greatly limits the biodegradable materials of polylactic acid. Industrialized production and marketing use

Method used

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  • Synthetic method of high-molecular-weight polylactic acid
  • Synthetic method of high-molecular-weight polylactic acid

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preparation example Construction

[0024] A method for synthesizing high-molecular-weight polylactic acid, comprising the following steps: feeding nitrogen into a reactor, mixing lactide with an initiator and a catalyst, raising the temperature so that the lactide undergoes ring-opening polymerization in the reactor, and prepares high-molecular-weight polylactic acid. The polylactic acid of molecular weight; The initiator is potassium benzoate, potassium phenate, tetramethylguanidine, triethoxyammonium bromide, boron trifluoride, trifluoroacetic acid, 4-nitro-N-methylethoxyphthaloyl One or a combination of two or more of imine, 5-aminoimidazole-4-carboxamide, and 5-amino-2-nitrobenzoic acid.

[0025] The ring-opening polymerization of lactide not only involves the activity of the monomer, but also the activity of the initiator. Therefore, the catalyst's catalysis of the monomer and the activity of the initiator have a great influence on the ring-opening polymerization of lactide. Selecting a suitable initiator,...

Embodiment 1

[0036] The L-lactic acid and stannous octoate catalyst with a molecular weight of 2500g / mol are 1000:2 according to the molar ratio of the substance, and the oligomeric L-lactic acid is added in the high-pressure glass reactor, and then the stannous octoate catalyst is added, and the reaction temperature is 230 °C, under the condition of vacuum degree of 0.02Mpa, react for 2h; obtain L-lactide by vacuum distillation, wash with dichloromethane for 3 times, dissolve unreacted lactic acid, filter with suction, and dry under vacuum at 50°C After 10 hours, the yield of L-lactide was 91.7%, and the purity was 99.3%.

Embodiment 2

[0038] The L-lactic acid with a molecular weight of 3000g / mol and the catalyst are 1000:3 according to the ratio of the substances, and the L-lactic acid is added to the high-pressure glass reactor, and then the stannous octoate and tin tetrachloride catalyst are added. The reaction temperature is 120 ℃, under the condition of vacuum degree of 0.06Mpa, react for 5h; obtain L-lactide by vacuum distillation, wash twice with chloroform, dissolve unreacted lactic acid, filter with suction, vacuum dry, vacuum dry The temperature was 60° C., the vacuum drying time was 8 hours, and the yield of L-lactide was 92.5%, and the purity was 99.1%.

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Abstract

The invention provides a synthetic method of high-molecular-weight polylactic acid, which comprises the following steps: taking high-purity L-lactide as a raw material, mixing the lactide with a novel initiator and a catalyst, and heating to carry out ring opening polymerization on the lactide in a reactor to prepare the high-molecular-weight polylactic acid. The novel initiator is matched with the catalyst for use, and the catalyst not only can activate the monomer, but also can activate the initiator, so that the rate and controllability of the lactide ring-opening polymerization reaction are improved. According to the method disclosed by the invention, the molecular mass of the polylactic acid is improved, the molecular weight of the synthesized polylactic acid can reach 200,000 g / mol or more, the reaction conditions are controllable, the production cost is reduced, the polylactic acid is easy to process and form, and the industrial production and application of the polylactic acid biodegradable material are facilitated.

Description

technical field [0001] The invention relates to the technical field of synthesis of biodegradable polymer materials, in particular to a synthesis method of high molecular weight polylactic acid. Background technique [0002] At present, petroleum-based plastics are widely used, but problems such as white pollution caused by their non-degradability are becoming more and more severe. Environmental protection issues have been highly concerned by people, and the non-toxic, non-polluting, green circular sustainable economic model has become a development trend. The emergence of degradable materials provides an effective way to solve the problem of environmental pollution. Polylactic acid is the largest industrialized and marketed variety among synthetic biodegradable polymer materials. It has good biocompatibility, degradability, good mechanical properties and processability, and can be used in food packaging , Disposable plastic products, biomedical materials and other fields,...

Claims

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Application Information

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IPC IPC(8): C08G63/08C08G63/78C08G63/85C08G63/87C08G63/83
CPCC08G63/08C08G63/78C08G63/85C08G63/87C08G63/83
Inventor 杨世美崔兆伟胡立楠刘晨
Owner 江苏睿安应用生物技术股份有限公司