Composite biomaterial

A biomaterial and bioluminescence technology, applied in the field of scaffold biomaterials, can solve problems such as difficulty in taste and/or taste experience

Pending Publication Date: 2022-03-22
SPIDERWORT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has proven difficult for the industry to produce the mouthfeel and / or taste experience of conventional meat-based food products

Method used

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  • Composite biomaterial
  • Composite biomaterial
  • Composite biomaterial

Examples

Experimental program
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Effect test

Embodiment 1

[0361] Example 1 - Composite Biomaterials Assembled by Gel Casting

[0362] In this example, different scaffold biomaterial subunits were combined by gel casting using hydrogels to link the subunits together. Although it is contemplated that a variety of different hydrogels could be used, this example primarily concerns gelatin, collagen, and agarose hydrogels. In certain embodiments, for example, the hydrogel can comprise gelatin, collagen, agarose, hyaluronic acid, alginate, fibrin, fibronectin, agar, PEG, PVA, or any combination thereof. In certain embodiments, the two or more scaffold biomaterial subunits can be formed as a scaffold around a hydrogel, where the hydrogel can have one or more scaffolds tuned for the desired application. a characteristic. In some embodiments, materials with different properties can be joined together in this manner. For example, in certain embodiments, different regions of the material may have different morphology, density, chemical funct...

Embodiment 2

[0398] Example 2 - Composite interlocking biomaterial

[0399] In this example, different scaffold biomaterial subunits are combined by shape-based interlocking. The geometry of the subunits is used to hold the assembled structure together. Although a wide range of interlock geometries are contemplated, this embodiment primarily uses plug-and-hole type interlocks similar to Lego blocks. Through interlocking, shape and / or structural customization can be achieved and larger macrostructures can be provided with varying degrees of flexibility and articulation as required for a particular application.

[0400] 3D biocompatible scaffolds composed of decellularized plant tissues have been developed. These biomaterials can support cell growth, invasion and / or proliferation in vitro and in vivo. As described, composites of cellulose scaffolds and hydrogels have been developed, where the presence of hydrogels can allow the temporary or permanent introduction of different biochemical ...

Embodiment 3

[0435] Example 3 - Composite Biomaterial of Plants and Bacterial Cellulose

[0436] In this example, a composite biomaterial comprising both plant and bacterial cellulose is provided. In certain embodiments, guided assembly-based biolithography (GAB) technology can be used to grow bacterial cellulose on decellularized or cast / printed plant cellulose sources to obtain cells with distinct and configurable regions. The ratio of cellulose with different crystal structures can be tuned as a composite biomaterial, and can allow different micromorphologies and densities. In certain embodiments, bacterial origin can deposit cellulose on a plant-derived cellulose-based scaffold biomaterial, eg, by having two different celluloses with different ratios and / or crystal structures. The resulting product may thus comprise different celluloses, which may have different functional chemical properties, density, porosity and / or mechanical properties. By combining celluloses, the resulting prod...

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Abstract

Provided herein are composite scaffold biomaterials comprising two or more scaffold biomaterial subunits, each subunit comprising a decellularized plant or fungal tissue from which tissue is removed cellular material and nucleic acid, the decellularized plant or fungal tissue having a three-dimensional porous structure, two or more scaffold biomaterial subunits are assembled into a composite scaffold biomaterial and held together by: gel casting with a hydrogel gel; complementary interlocking geometries of two or more scaffold biomaterial subunits; biolithography (GAB) based on guided assembly; carrying out chemical crosslinking; or any combination thereof. Methods for producing these scaffold biomaterials and methods and uses thereof are also provided.

Description

technical field [0001] The present invention generally relates to scaffold biomaterials. More specifically, the present invention relates to composite scaffold biomaterials comprising decellularized plant and / or fungal tissue, such as those comprising two or more scaffold biomaterial subunits. Background technique [0002] Living tissue is a complex structure composed of a range of different cell types. Multiple cell types can interact to carry out specialized functions in vivo. Cellular and extracellular matrix organization is often directly related to function; thus, impaired cellular, tissue, and / or organ function can result from biochemical and physical defects ranging from genetic disorders to physical damage. The biochemical and physical environment in vivo can vary within, at interfaces and between different tissue types and organs. As such, recreating or approximating the natural in vivo environment of cells is difficult. [0003] A great deal of research has foc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/04A23L29/00A23L33/00A61K47/38A61K47/46A61K9/10A61L27/50A61L27/52A61L27/54B01D11/02B33Y80/00C08J3/075C08J3/24C08J5/12C08L1/02C09J5/00C12N1/14C12N5/00C12N5/07C12N5/077A23L13/00A23L17/00
CPCA61K9/10A61K47/38A61K47/46A61L27/54B33Y80/00C08J3/075C08J3/24C08L1/02A23L13/00A23L17/00A23L15/00A23L29/20A23L31/00A23L19/09B01D11/0288B01D11/0257A61L27/3637A61L27/3683A61L27/48A61L27/3826A61L27/34C09D105/12C09D105/04C09D105/08C09D189/06C12N5/0062C12N2533/78C12N2533/90C12N2533/54C12N2537/10C08J2301/02C08L5/08C08L5/04B33Y10/00B33Y70/00A61L27/222A61L27/52A61L2300/232A61L2400/08
Inventor R·希基A·E·佩林S·坎普萨诺P·C·德苏萨菲利亚蒂舍尔K·奥雷塞夫斯基
Owner SPIDERWORT INC
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