Preparation method and application of novel water-soluble acne-removing composite material

A composite material and water-soluble technology, which is applied in the field of skin care products, can solve the problems of poor compounding ability of surfactants and drug leakage, etc., and achieve the effect of good acne removal effect, improved absorption speed, and easy absorption

Pending Publication Date: 2022-03-25
湖南亚大丰晖新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of liposomes is the biggest reason that limits the industrialization of liposomes, including agglomeration caused by uneven particle size distribution during preparation, drug leakage caused by lipid membrane instability, poor compounding ability with other surfactants, etc.

Method used

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  • Preparation method and application of novel water-soluble acne-removing composite material
  • Preparation method and application of novel water-soluble acne-removing composite material
  • Preparation method and application of novel water-soluble acne-removing composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Weigh 20mg of poloxamer 407, 20mg of lecithin, 20mg of cholesterol, 10mg of PEG2000, 50mg of sodium hyaluronate, 100mg of white root extract, 100mg of salvia miltiorrhiza extract, 100mg of eucommia leaf extract, and 100mg of licorice extract in 50mL of two Methyl chloride was used as the organic phase, stirred and mixed at 3000rpm to form colostrum; then 200mg cymene was weighed and dissolved in 37mL phosphate buffered saline (PBS) as the water phase; the colostrum was quickly injected into the rapidly stirred water phase with a syringe , the speed of rapid stirring is 4000rpm, forms double emulsion, and the double emulsion that forms is concentrated under reduced pressure on rotary evaporator to remove residual dichloromethane, and the residue adjusts the solution volume to 100mL with PBS, promptly obtains primary liposome; After the liposomes were ultrasonically treated for 30 minutes and left to stand at room temperature for 12 hours, a single-chamber liposome with un...

Embodiment 2

[0036] Weigh 1 mg poloxamer 407, 1 mg lecithin, 1 mg cholesterol, 1 mg PEG2000, 1 mg sodium hyaluronate, 1 mg white root extract, 1 mg salvia miltiorrhiza extract, 1 mg Eucommia leaf extract, 1 mg licorice extract and dissolve in 50 mL distilled water Methyl chloride was used as the organic phase, stirred and mixed at 2800rpm to form colostrum; then 100mg cymene was weighed and dissolved in 37mL phosphate buffered saline (PBS) as the water phase; the colostrum was quickly injected into the rapidly stirred water phase with a syringe , the speed of rapid stirring is 1000rpm, forms double emulsion, and the double emulsion that forms forms is concentrated under reduced pressure on rotary evaporator to remove residual dichloromethane, and the residue is adjusted to 10mL with PBS solution volume, promptly obtains primary liposome; Primary liposome is obtained; After the liposomes were ultrasonically treated for 20 minutes and left to stand at room temperature for 10 hours, a single-c...

Embodiment 3

[0038] Weigh 100mg poloxamer 407, 100mg lecithin, 100mg cholesterol, 100mg PEG2000, 100mg sodium hyaluronate, 50mg white root extract, 50mg salvia miltiorrhiza extract, 50mg Eucommia leaf extract, 50mg licorice extract and dissolve in 50mL Methyl chloride was used as the organic phase, stirred and mixed at 3200rpm to form colostrum; then 150mg cymene was weighed and dissolved in 37mL phosphate buffered saline (PBS) as the water phase; the colostrum was quickly injected into the rapidly stirred water phase with a syringe , the speed of rapid stirring is 3000rpm, forms double emulsion, and the double emulsion that forms forms is concentrated under reduced pressure on the rotary evaporator to remove residual dichloromethane, and the residue is adjusted to 50mL with PBS solution volume, promptly obtains primary liposome; After the liposomes were ultrasonically treated for 40 minutes and left to stand at room temperature for 14 hours, a single-chamber liposome with uniform particle ...

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Abstract

The invention discloses a novel water-soluble acne-removing composite material, and relates to the technical field of skin care products. The preparation method of the novel water-soluble acne-removing composite material disclosed by the invention comprises the following steps: dissolving poloxamer 407, lecithin, cholesterol, PEG2000, sodium hyaluronate, a rhizoma bletillae extract, a radix salviae miltiorrhizae extract, a folium cortex eucommiae extract and a liquorice root extract in dichloromethane, and uniformly stirring and mixing to form primary emulsion; then cymene is dissolved in a phosphate buffer solution to serve as a water phase; rapidly injecting the primary emulsion into a rapidly stirred water phase by using an injector, removing the residual organic solvent, and diluting the obtained residue with PBS to obtain a primary liposome; and carrying out ultrasonic treatment on the primary liposome, and standing at room temperature to obtain the liposome. The invention provides a preparation method of a novel water-soluble acne-removing composite material, and the method is simple to operate and can be suitable for industrial production; the water-soluble liposome improves the absorption speed of skin to components, mildly removes acnes, does not hurt the skin, and has a good acne removal effect.

Description

technical field [0001] The invention belongs to the technical field of skin care products, and in particular relates to a preparation method of a novel water-soluble acne-removing composite material. Background technique [0002] Acne is medically called acne, also known as comedo, acne, pimple, etc. It is a chronic inflammation of the pilosebaceous glands. Generally speaking, acne caused by external factors is relatively easy to cure. As long as you pay attention to cleaning and caring for the skin correctly, and prescribe the right medicine and use Chinese medicines containing anti-acne ingredients, you can generally recover. However, in the actual acne removal and repair process, it takes a long time, and acne marks are easy to be left after acne removal, which is difficult to remove and affects the appearance. Conventional acne-removing masks on the market contain salicylic acid, which removes acne by brushing acid. Repeated use will damage the skin, increase skin sensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/55A61K8/63A61K8/86A61K8/73A61K8/14A61Q19/00A61P17/10
CPCA61K8/9794A61K8/9789A61K8/553A61K8/63A61K8/86A61K8/735A61K8/14A61Q19/00A61P17/10A61K2800/5922
Inventor 许澎林芝肖建波刘彩云
Owner 湖南亚大丰晖新材料有限公司
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