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High-toughness poly (p-dioxanone) absorbable silk yarn and preparation method thereof

A technology of polydioxanone and high toughness, which is applied in the field of biomedical polymer materials, and can solve the problem that the strength and modulus of PPDO threads cannot meet the requirements for the use of sutures, and the inability to obtain high-crystallinity PPDO threads and the crystallization rate of PPDO Slow and other problems, to avoid poor processing stability, easy to be identified, and convenient for surgical operations

Active Publication Date: 2022-04-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, on the one hand, due to the slow crystallization rate of PPDO (Márquez, Y.; Franco, L.; Turon, P.; Martínez, J.C.; Puiggalí, J. Polymers 2016, 8, 351.), high Crystallinity of PPDO thread, which leads to the strength and modulus of PPDO thread cannot meet the requirements of suture; on the other hand, the melt strength of PPDO is low, and the thread is prone to breakage during molding processing, resulting in poor continuity in the production process

Method used

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  • High-toughness poly (p-dioxanone) absorbable silk yarn and preparation method thereof
  • High-toughness poly (p-dioxanone) absorbable silk yarn and preparation method thereof
  • High-toughness poly (p-dioxanone) absorbable silk yarn and preparation method thereof

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preparation example Construction

[0033] A kind of preparation method of high tenacity polydioxanone absorbable thread of the present invention, concrete steps are as follows:

[0034] S1 In terms of mass fraction, 0.1% to 2.0% of pigment and 98% to 99.9% of PPDO raw material with high molecular weight and narrow distribution are mechanically mixed at 20 to 30°C for 30 to 90 minutes, and the stirring rate is 300 to 600r / min to obtain PPDO / Pigment raw material mixing system;

[0035] S2 Add the PPDO / pigment raw material mixing system into the twin-screw extruder at a feeding speed of 5-7r / min. The PPDO / pigment mixing system is melted and extruded through the conveying compression section, the melting section and the metering section of the twin-screw extruder. The extrudate is forced to cool to room temperature through circulating cooling water to obtain a PPDO / pigment blend;

[0036] S3 pelletize the PPDO / pigment blend, place the pellets in a vacuum drying oven, and dry at 60°C until the water content is les...

Embodiment 1

[0042] (1) Mechanical mixing of D&C Violet 2 and PPDO: mechanically mix D&C Violet powder with a mass percentage of 0.5% and PPDO with a mass percentage of 99.5%, and keep stirring at 30°C for 60 min;

[0043] (2) Preparation of D&C Violet 2 / PPDO blend: put the mixed D&C Violet 2 / PPDO in a twin-screw extruder for melt blending and extrusion, and the extruder conveys the temperature of the compression section, the melting section and the metering section Set at 100°C, 120°C and 110°C, set the speed of the main engine at 100r / min, and the feeding speed at 5r / min, then extrude the blend into strands for forced cooling and pelletizing, and dry at 60°C to a water content not higher than 0.01% of its own weight;

[0044] (3) Preparation of PPDO absorbable yarn by melt spinning: Melt spinning the above dried D&C Purple 2 / PPDO extruded pellets, setting the extrusion temperature at 105°C, preheating time for 10 minutes, and drawing The stretch ratio is 10 / 1, the extrusion rate is 0.5mm / ...

Embodiment 2

[0046] (1) Mechanical mixing of D&C Violet 2 and PPDO: mechanically mix D&C Violet powder with a mass percentage of 0.1% and PPDO with a mass percentage of 99.9%, and keep stirring at 30°C for 90 min;

[0047] (2) Preparation of D&C Violet 2 / PPDO blend: put the mixed D&C Violet 2 / PPDO in a twin-screw extruder for melt blending and extrusion, and the extruder conveys the temperature of the compression section, the melting section and the metering section Set at 100°C, 130°C and 120°C, set the speed of the main engine at 110r / min, and the feeding speed at 6r / min, then extrude the blend into filaments, force cooling and pelletizing, and dry at 60°C to a water content not higher than 0.01% of its own weight;

[0048] (3) Preparation of PPDO absorbable yarn by melt spinning: Melt spinning the above dried D&C purple 2 / PPDO extruded pellets, setting the extrusion temperature at 115°C, preheating time for 8 minutes, and drawing The stretch ratio is 20 / 1, the extrusion rate is 1mm / s, ...

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Abstract

The invention discloses a high-toughness poly (p-dioxanone) absorbable silk yarn and a preparation method thereof.The preparation method comprises the steps that high-molecular-weight narrow-distribution PPDO and pigment are mixed to obtain a mixed system, the mixed system is added into an extruder and subjected to melt extrusion through a conveying compression section, a melting section and a metering section of the extruder, and the extrudate is cooled, granulated and dried to obtain the high-toughness poly (p-dioxanone) absorbable silk yarn. The PPDO / pigment blend extruded material particles are obtained; and heating the PPDO / pigment blend extruded material particles to a temperature above a melting point, maintaining the temperature, extruding the molten PPDO / pigment blend extruded material particles through a mouth mold according to a drawing ratio of 10 / 1-30 / 1, and carrying out drawing orientation on the extruded filaments through a drawing machine at a drawing rate of 20mm / s-200mm / s to obtain the high-toughness PPDO absorbable silk yarn. According to the method, the PPDO raw material with high molecular weight and narrow molecular weight distribution is selected, high crystallinity and orientation degree are obtained through the melt spinning process, meanwhile, a large number of fiber crystal structures are formed in the silk yarn through the high draw ratio, then the mechanical property and thermal stability of the PPDO silk yarn are improved, and finally the high-toughness PPDO absorbable silk yarn is obtained.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, in particular to a high-toughness polydioxanone absorbable silk thread and a preparation method thereof. Background technique [0002] Poly(p-dioxanone), PPDO is an aliphatic polyester with good biocompatibility, bioabsorbability and degradability. PPDO has excellent toughness and can be used as a medical suture (Yang, K.-K.; Wang, X.-L.; Wang, Y.-Z. Polym. Rev. 2002, 42, 373). However, on the one hand, due to the slow crystallization rate of PPDO (Márquez, Y.; Franco, L.; Turon, P.; Martínez, J.C.; Puiggalí, J. Polymers 2016, 8, 351.), high The crystallinity of the PPDO thread leads to the fact that the strength and modulus of the PPDO thread cannot meet the requirements for the use of sutures; on the other hand, the PPDO melt strength is low, and the thread is prone to breakage during the molding process, resulting in poor continuity in the production process. Contents o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/92D01F1/04D01D5/08A61L17/10
Inventor 杨书桂张启路刘峰李泽鹏都慧聪舒茂国
Owner XI AN JIAOTONG UNIV
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