3D printing xanthan gum hydrogel stent and preparation method thereof

A 3D printing and xanthan gum technology, applied in the field of medical supplies, can solve the problems of easy damage, poor water resistance, poor environmental performance, etc., and achieve the effects of fast curing time, improved light absorption capacity, and good environmental performance

Active Publication Date: 2022-04-08
GUANGXI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrogel prepared from xanthan gum has the characteristics of strong hydrophilicity, non-toxicity, degradability and good biocompatibility, but the glucuronic acid and pyruvate groups on the side chain of xanthan gum and the whole molecule A large number of hydroxyl groups in the main chain structure make it easily soluble in water, poor water resistance, and easy to damage; and at this stage, photocuring is generally prepared by using ultraviolet photoinitiators, which need to be irradiated by ultraviolet mercury lamps, and LED lights cannot be used directly. Irradiation curing, poor environmental performance

Method used

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  • 3D printing xanthan gum hydrogel stent and preparation method thereof
  • 3D printing xanthan gum hydrogel stent and preparation method thereof
  • 3D printing xanthan gum hydrogel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A modified photoinitiator is prepared, and the modified photoinitiator is made by the following steps:

[0039] Step S1: add vitamin B1 and p-fluorobenzaldehyde to the flask, then add triethylamine, heat up to 90 ° C, and react for 24 hours, then add acetic acid, ferric chloride, copper sulfate, and sodium nitrate, reflux for 5 hours, and cool to After room temperature, deionized water was added, and after extraction with dichloromethane, the organic layer was removed from dichloromethane, and recrystallized with acetic acid to obtain intermediate 1; wherein vitamin B1, p-fluorobenzaldehyde, triethylamine, acetic acid, trichloride The dosage ratio of iron, copper sulfate and sodium nitrate is 1mmol: 40mmol: 1.4g: 25mL: 0.5g: 0.1g: 1.7g;

[0040] Step S2: add intermediate 1, hydroxylamine hydrochloride and sodium hydroxide into the flask, then add tetrahydrofuran and deionized water, heat under reflux for 10 hours, and after the reaction ends, obtain functional monomer A...

Embodiment 2

[0046] A modified photoinitiator is prepared, and the modified photoinitiator is made by the following steps:

[0047] Step S1: add vitamin B1 and p-fluorobenzaldehyde to the flask, then add triethylamine, heat up to 90 ° C, and react for 24 hours, then add acetic acid, ferric chloride, copper sulfate, and sodium nitrate, reflux for 5 hours, and cool to After room temperature, deionized water was added, and after extraction with dichloromethane, the organic layer was removed from dichloromethane, and recrystallized with acetic acid to obtain intermediate 1; wherein vitamin B1, p-fluorobenzaldehyde, triethylamine, acetic acid, trichloride The dosage ratio of iron, copper sulfate and sodium nitrate is 1mmol: 40mmol: 1.4g: 25mL: 0.5g: 0.1g: 1.7g;

[0048] Step S2: Add intermediate 1, hydroxylamine hydrochloride and sodium hydroxide into the flask, then add tetrahydrofuran and deionized water, heat under reflux for 11 h, and after the reaction ends, obtain functional monomer A; wh...

Embodiment 3

[0054] A modified photoinitiator is prepared, and the modified photoinitiator is made by the following steps:

[0055] Step S1: add vitamin B1 and p-fluorobenzaldehyde to the flask, then add triethylamine, heat up to 90 ° C, and react for 24 hours, then add acetic acid, ferric chloride, copper sulfate, and sodium nitrate, reflux for 5 hours, and cool to After room temperature, deionized water was added, and after extraction with dichloromethane, the organic layer was removed from dichloromethane, and recrystallized with acetic acid to obtain intermediate 1; wherein vitamin B1, p-fluorobenzaldehyde, triethylamine, acetic acid, trichloride The dosage ratio of iron, copper sulfate and sodium nitrate is 1mmol: 40mmol: 1.4g: 25mL: 0.5g: 0.1g: 1.7g;

[0056] Step S2: Add intermediate 1, hydroxylamine hydrochloride and sodium hydroxide into the flask, then add tetrahydrofuran and deionized water, heat under reflux for 12 hours, and after the reaction ends, obtain functional monomer A...

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Abstract

The invention discloses a 3D printing xanthan gum hydrogel stent and a preparation method thereof, and belongs to the technical field of medical supplies, the 3D printing xanthan gum hydrogel stent is prepared from modified xanthan gum, distilled water, a modified photoinitiator and active cells according to a dosage ratio of 3g: 100mL: 1g: 1 * 10 < 9 >, and is irradiated and cured by using a 405nm light source to obtain the 3D printing xanthan gum hydrogel stent. According to the invention, methacrylic anhydride reacts with hydroxyl groups on the surface of xanthan gum, on one hand, the number of hydroxyl groups in the xanthan adhesive tape is reduced, the hydrophilicity of the xanthan adhesive tape is reduced, on the other hand, the xanthan adhesive tape is endowed with photopolymerization capability due to introduction of methacrylic acid groups, and meanwhile, a modified photoinitiator is prepared; according to the present invention, the 3D printing material is added, such that the printed stent can be irradiated and cured under the 405 nm visible light LED light source so as to avoid the use of the ultraviolet mercury lamp, such that the good environmental protection performance is provided, and the active cells are added so as to make the prepared stent be well suitable for soft tissue repair.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a 3D printed xanthan gum hydrogel support and a preparation method thereof. Background technique [0002] 3D printing technology is a material processing and molding technology, which provides a new treatment method for the regeneration and repair of human tissues and organs. Currently, hydrogels are a commonly used ink for 3D printing, which have high water content and have a fibrous network structure similar to the extracellular matrix of tissues. The raw materials of hydrogels can be divided into synthetic materials and natural biomaterials, among which, natural material hydrogels have good biocompatibility and low immunogenicity. [0003] Xanthan gum is a linear water-soluble natural polysaccharide composed of "pentasaccharide repeating units" composed of D-glucan, D-mannose, D-glucuronic acid, acetic acid and pyruvic acid. The hydrogel prepared from xanthan gum ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/38A61L27/52A61L27/54C07D405/14B33Y80/00B33Y70/10
Inventor 郑立高明覃再嫩杨屹峰勒义官赵劲民
Owner GUANGXI MEDICAL UNIVERSITY
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