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Porous cellulose microsphere adsorbent with core-shell structure as well as preparation method and application of porous cellulose microsphere adsorbent

A porous cellulose and microsphere adsorption technology, applied in chemical instruments and methods, other chemical processes, blood circulation treatment, etc., can solve problems such as unfavorable transfer and adsorption of toxin substances, influence on blood composition, complex preparation process, etc.

Pending Publication Date: 2022-04-29
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In terms of the pore structure of the adsorbent, there is no obvious difference in the pore structure of the surface layer and the inner layer of the adsorbent prepared by the existing conventional technology. If the pore size is large, the macromolecular substances in the blood, such as albumin and globulin, will Even blood cells can enter the pores, affecting normal blood composition, and there is a greater safety risk; if the pore size is small, the material to be adsorbed will enter the pores through the action of molecular sieves, and the pore space will be limited, which will affect the adsorption capacity.
Patent document CN109092276A discloses the use of solid porogens such as calcium carbonate and calcium phosphate, which are insoluble in water but soluble in dilute acid, to prepare spherical shapes with multi-level pore distribution through multiple suspension emulsification methods, but this method emulsifies the same material multiple times , the inner core will be dissolved or swelled, and the pores prepared by solid porogens have poor permeability, which is not conducive to the transmission and adsorption of clinical β2-MG and other medium and large molecular toxins in the pores
Our research team has prepared cellulose microspheres with a hierarchical porous structure (CN112191232A) by a secondary pore-forming method, but the preparation process is relatively complicated

Method used

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  • Porous cellulose microsphere adsorbent with core-shell structure as well as preparation method and application of porous cellulose microsphere adsorbent
  • Porous cellulose microsphere adsorbent with core-shell structure as well as preparation method and application of porous cellulose microsphere adsorbent
  • Porous cellulose microsphere adsorbent with core-shell structure as well as preparation method and application of porous cellulose microsphere adsorbent

Examples

Experimental program
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Embodiment 1

[0041] This embodiment provides a kind of porous cellulose microsphere with core-shell structure, and its preparation method comprises the following steps:

[0042] (1) Preparation of microspheres: Weigh 10 g of cellulose diacetate, dissolve in a mixed solution of 30 mL of dichloromethane and 20 mL of dimethyl sulfoxide, then add 30 mL of ethylene glycol diacetate and 20 mL of n-octanol, and stir well mixed. Add the above solution dropwise to 400mL PVA solution with a mass fraction of 2% at 37±1°C at a constant speed, and keep stirring at a constant temperature of 140rpm-160rpm for 12h to obtain cellulose acetate microspheres. Wash the carrier with deionized water, remove the surface PVA, add 200mL 2mol / L sodium hydroxide solution to the microspheres, stir at room temperature for 5h, and then wash with a large amount of deionized water until neutral. Then add ethanol to purify the microspheres, remove the internal solvent, and then sieve with a sieve to obtain cellulose micro...

Embodiment 2

[0048] This example provides a porous cellulose microsphere with a core-shell structure. The difference between the microsphere preparation step and Example 1 is that this example improves the water-insoluble The proportion of solvent.

[0049] Specifically, the preparation steps of the microspheres in this example include: weighing 10 g of cellulose diacetate, dissolving it in a mixed solution of 40 mL of dichloromethane and 10 mL of dimethyl sulfoxide, and then adding 30 mL of ethylene glycol diacetate, n-octanol 20mL, stir and mix well. Add the above solution dropwise to 400mL PVA solution with a mass fraction of 2% at 37±1°C at a constant speed, and keep stirring at a constant temperature of 140rpm-160rpm for 12h to obtain cellulose acetate microspheres. Wash the carrier with deionized water, remove the surface PVA, add 200mL 2mol / L sodium hydroxide solution to the microspheres, stir at room temperature for 5h, and then wash with a large amount of deionized water until ne...

Embodiment 3

[0052] This example provides a porous cellulose microsphere with a core-shell structure. The difference between the microsphere preparation step and Example 1 is that this example improves the concentration of the water-soluble solvent in the microsphere preparation step compared with Example 1. Proportion.

[0053] Specifically, the preparation steps of the microspheres in this example include: weighing 10 g of cellulose diacetate, dissolving it in a mixed solution of 10 mL of dichloromethane and 40 mL of dimethyl sulfoxide, and then adding 30 mL of ethylene glycol diacetate, n-octanol 20mL, stir and mix well. Add the above solution dropwise to 400mL PVA solution with a mass fraction of 2% at 37±1°C at a constant speed, and keep stirring at a constant temperature of 140rpm-160rpm for 12h to obtain cellulose acetate microspheres. Wash the carrier with deionized water, remove the surface PVA, add 200mL 2mol / L sodium hydroxide solution to the microspheres, stir at room temperat...

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Abstract

The invention relates to a porous cellulose microsphere adsorbent with a core-shell structure and a preparation method and application thereof.The porous cellulose microsphere adsorbent is of the core-shell structure and comprises an inner core and a shell layer, the inner core is coated with the shell layer, and the shell layer and the inner core are mainly formed by a continuous integrated cellulose matrix; the porous cellulose microsphere adsorbent has a continuous through hole structure, and the pore diameter of a shell layer is smaller than that of an inner core. The preparation method of the porous cellulose microsphere adsorbent with the core-shell structure comprises the following steps: mixing cellulose acetate with a mixed solvent and a mixed pore-foaming agent, curing in an aqueous solution to form a sphere, and forming a pore channel structure with inner core macropores and outer shell pores through the matching of the mixed solvent and the mixed pore-foaming agent. The adsorbent disclosed by the invention has the advantages of high adsorption rate on beta 2-MG, reduction of adsorption on beneficial protein and blood cells, high safety, suitability for blood perfusion and simplification of a preparation process.

Description

technical field [0001] The invention relates to the field of blood purification, in particular to a porous cellulose microsphere adsorbent with a core-shell structure and a preparation method and application thereof. Background technique [0002] Uremia is caused by the gradual irreversible decline of renal function caused by various kidney diseases in the body, which eventually leads to the loss of renal function, and the metabolic wastes in the body, such as β2 microglobulin (β2-MG), cannot be discharged in time and are produced in large quantities. A series of complex clinical syndromes. Among them, the accumulation of β2-MG can lead to amyloidosis and carpal tunnel syndrome, the accumulation of PTH can lead to renal bone disease and ectopic calcification, and the increase and accumulation of IL-6 can lead to chronic inflammatory reactions throughout the body, and more and more studies have shown that These inflammatory reactions are related to arteriosclerosis and malnu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/28B01J20/30A61M1/36
CPCB01J20/24B01J20/28021A61M1/36
Inventor 董凡蔡礼桃
Owner JAFRON BIOMEDICAL