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Application of polyvinylidene fluoride-chlorotrifluoroethylene film as oxygenation film

A technology of chlorotrifluoroethylene and polyvinylidene fluoride, applied in membrane, membrane technology, semi-permeable membrane separation and other directions, can solve problems such as excessive pore size and blood leakage, achieve small separation pore size, reduce damage, and resist blood leakage Excellent performance

Pending Publication Date: 2022-05-06
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Using PVDF-CTFE material, PVDF-CTFE hydrophobic membrane with small pore size is prepared by non-solvent-induced phase separation method and used as an oxygenation membrane, which can solve the problem of blood leakage caused by excessively large pore size of polypropylene oxygenation membrane during long-term use. The ability is greater than that of polymethylpentene material with dense skin

Method used

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  • Application of polyvinylidene fluoride-chlorotrifluoroethylene film as oxygenation film
  • Application of polyvinylidene fluoride-chlorotrifluoroethylene film as oxygenation film
  • Application of polyvinylidene fluoride-chlorotrifluoroethylene film as oxygenation film

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Put 20wt% PVDF-CTFE resin, 10wt% polyethylene glycol (molecular weight 4000) and 70wt% solvent dimethylacetamide into the spinning kettle, stir at 90°C for 6 hours to dissolve evenly, and let it stand for 4 hours for defoaming , together with the core liquid water, is inserted into the tubular spinning nozzle, extruded, and enters the coagulation bath tank. At a spinning draft speed of 20 m / min, a PVDF-CTFE hollow fiber membrane is spun out. After washing, Dry directly to obtain PVDF-CTFE oxygenated membrane. The PVDF-CTFE oxygenated membrane has an inner diameter of 200 μm and a wall thickness of 40 μm. The inner wall of the membrane filament is smooth and flat, without a dense outer skin layer, which can allow blood to flow through the tube. The gas permeation rate is 35mL / min·cm 2 ·bar, the water penetration pressure is 0.50MPa, the maximum pore size measured by the ethanol bubble point method is 0.06μm, the porosity is 83%, and the plasma leakage time is greater th...

Embodiment 2

[0050] Put 25wt% PVDF-CTFE resin, 10wt% ethylene glycol and 65wt% solvent N-methylpyrrolidone into the spinning kettle, stir at 70°C for 6 hours to dissolve evenly, let stand for defoaming for 4 hours, and mix with dimethyl ethyl The core liquid of the aqueous solution with an amide content of 70wt% is inserted into the tubular spinning nozzle, extruded, and enters the coagulation bath tank, and the PVDF-CTFE hollow fiber is spun at a spinning draft speed of 60 m / min The membrane was washed with water and dried directly to obtain a PVDF-CTFE oxygenated membrane. The PVDF-CTFE oxygenated membrane has an inner diameter of 200 μm and a wall thickness of 50 μm. The gas permeation rate is 22mL / min·cm 2 ·bar, the water penetration pressure is 0.60MPa, the maximum pore size measured by the ethanol bubble point method is 0.08μm, the porosity is 81%, and the plasma leakage time is greater than 20 days.

Embodiment 3

[0052] Put 20wt% polyvinylidene fluoride-chlorotrifluoroethylene resin, 8wt% polyethylene glycol (molecular weight 200) and 72wt% solvent sulfolane into the spinning kettle, stir at 80°C for 6 hours to dissolve evenly, and let it stand for degassing for 4 After one hour, together with the core liquid of the aqueous solution with a dimethylacetamide content of 70wt%, by inserting a tubular spinning nozzle, extruding, entering the coagulation bath water tank, under the spinning drafting speed of 60 m / min, A PVDF-CTFE hollow fiber membrane is spun, washed with water, and dried to obtain a PVDF-CTFE oxygenated membrane. The PVDF-CTFE oxygenated membrane has an inner diameter of 200 μm and a wall thickness of 60 μm. The gas permeation rate is 32mL / min·cm 2 ·bar, the water penetration pressure is 0.40MPa, the maximum pore size measured by the ethanol bubble point method is 0.05μm, the porosity is 84%, and the plasma leakage time is greater than 20 days.

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Abstract

The invention relates to application of a polyvinylidene fluoride-trifluorochlor oethylene membrane as an oxygenation membrane. The polyvinylidene fluoride-trifluorochlor oethylene membrane is in a hollow fiber shape, the inner diameter is 200 microns, the wall thickness is 30-60 microns, the porosity is larger than 80%, the gas permeation rate is 20-200 mL / min.cm < 2 >. Bar, the water permeation pressure is 0.30-0.80 MPa, the maximum aperture is 0.01-0.10 microns, and the plasma leakage time is longer than 20 days. The oxygenation capacity is higher than that of a polymethylpentene material with a compact skin layer.

Description

technical field [0001] The invention belongs to the application field of membrane materials, and relates to a polyvinylidene fluoride-chlorotrifluoroethylene (PVDF-CTFE) membrane, especially the application of the PVDF-CTFE membrane as an oxygenation membrane. Background technique [0002] Membrane oxygenator, also known as membrane artificial lung, is a disposable artificial device capable of blood gas exchange. Based on the principle of biological lung and alveolar gas exchange, it integrates the functions of oxygenation, temperature change, blood storage, filtration, and blood recovery. It is used to replace the heart function and lung function to oxygenate blood and remove carbon dioxide to meet the needs of patients during surgery. need. Its characteristic is that the blood does not directly contact, and the bionic property is good. The main goal of the oxygenation membrane is to remove CO from the blood while accurately supplying oxygen 2 . [0003] The requirement...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/32B01D71/34B01D67/00B01D69/02B01D69/08A61M1/36
CPCB01D71/32B01D71/34B01D67/0016B01D67/0093B01D69/02B01D69/08A61M1/3621B01D2325/02B01D2325/04
Inventor 吕晓龙龙婷婷荣新雨杨可
Owner TIANJIN POLYTECHNIC UNIV
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