Metal support filled with magnetic composite material and preparation method of metal support

A magnetic composite material and metal stent technology, which can be used in additive processing, prosthesis, tissue regeneration, etc., can solve the problem of inability to achieve cell filling and growth, achieve high porosity, stable mechanical structure, and promote angiogenesis.

Pending Publication Date: 2022-05-17
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to solve the above problems, many studies have modified titanium alloy materials, such as chemical treatment, bioactive coating and surface adhesion of various growth factors, stem cells, etc., but u

Method used

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  • Metal support filled with magnetic composite material and preparation method of metal support
  • Metal support filled with magnetic composite material and preparation method of metal support
  • Metal support filled with magnetic composite material and preparation method of metal support

Examples

Experimental program
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Effect test

Embodiment 1

[0047] The titanium alloy stent filled with the magnetic composite material in this embodiment is prepared according to the mass ratio of nano-hydroxyapatite powder, gelatin and nano-magnetic particles at 1:1:1.

[0048] The preparation method of the titanium alloy stent filled with the above-mentioned magnetic composite material comprises the following steps:

[0049] (1) Use CAD software to construct a 3D digital model with a rhombohedral dodecahedron as the basic unit, a pore column of 300 μm, a pore diameter of 500 μm, and a porosity of 80%.

[0050] (2) printing a porous titanium alloy support according to the 3D digital model in step (1);

[0051] (3) 2.5g nano magnetic particle powder (γ-Fe 2 o 3 , Ruicun, ferric oxide wrapped with polydextrose sorbitol carboxymethyl ether) was dissolved in 50ml of deionized water, ultrasonically dispersed in an ultrasonic cleaning machine, and then treated with an ultrasonic cell pulverizer to uniformly disperse the nano-magnetic par...

Embodiment 2

[0062] The titanium alloy stent filled with the magnetic composite material in this embodiment is prepared according to the mass ratio of hydroxyapatite powder, gelatin and nano-magnetic particles at 1:1:0.5.

[0063] The preparation method of the titanium alloy stent filled with the above-mentioned magnetic composite material comprises the following steps:

[0064] (1) Use CAD software to construct a 3D digital model with a rhombohedral dodecahedron as the basic unit, a pore column of 300 μm, a pore diameter of 500 μm, and a porosity of 80%.

[0065] (2) printing a porous titanium alloy support according to the 3D digital model in step (1);

[0066] (3) Dissolve 1.25g of nano-magnetic particle powder in 50ml of deionized water, first ultrasonically disperse it in an ultrasonic cleaning machine, and then use an ultrasonic cell pulverizer to process the nano-magnetic particle evenly in deionized water, and obtain a mass solubility of 2.5% nanomagnetic particle solution.

[00...

Embodiment 3

[0071] The titanium alloy stent filled with the magnetic composite material in this embodiment is prepared according to the mass ratio of hydroxyapatite powder, gelatin and nano-magnetic particles of 1:1:0.1.

[0072] The preparation method of the titanium alloy stent filled with the above-mentioned magnetic composite material comprises the following steps:

[0073] (1) Use CAD software to construct a 3D digital model with a rhombohedral dodecahedron as the basic unit, a pore column of 300 μm, a pore diameter of 500 μm, and a porosity of 80%.

[0074] (2) printing a porous titanium alloy support according to the 3D digital model in step (1);

[0075] (3) Dissolve 0.25g of nano-magnetic particle powder in 50ml of deionized water, first ultrasonically disperse it in an ultrasonic cleaning machine, and then use an ultrasonic cell pulverizer to process the nano-magnetic particle evenly in deionized water, and obtain a mass solubility of 0.5% nanomagnetic particle solution.

[00...

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Abstract

The invention discloses a metal stent filled with a magnetic composite material, the metal stent is composed of a magnetic composite material and a three-dimensional porous metal stent, the magnetic composite material is formed by nano magnetic particles, gelatin and hydroxyapatite powder, and the metal stent is filled with the magnetic composite material. The mass ratio of the hydroxyapatite powder to the gelatin to the nano magnetic particles in the magnetic composite material is 1: 1: (0.1-1). According to the invention, two bone matrix main components (collagen and nano-hydroxyapatite) are adopted, and a degradable bionic three-dimensional micro-scaffold is built in each hole of porous titanium; meanwhile, nano magnetic particles and a static magnetic field are introduced to promote angiogenesis and stimulate differentiation of preosteoblasts to osteoblasts and deposition of extracellular matrixes, so that an optimal proliferation and differentiation environment is provided for bone formation related cells.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a metal stent filled with magnetic composite materials and a preparation method thereof. Background technique [0002] Osteonecrosis of femoral head (ONFH) is a debilitating disease affecting a relatively young population, resulting in progressive collapse of the femoral head and subsequent symptomatic hip arthritis. In the United States, more than 20,000 new cases of osteonecrosis of the femoral head are diagnosed every year, while the number of non-traumatic ONFH patients in China is as high as 8.12 million. Although total hip arthroplasty has achieved satisfactory results in the treatment of advanced ONFH, for young ONFH patients, considering the activity requirements, prosthesis life and the difficulty of revision surgery, before irreversible femoral head collapse Optimal hip-preserving treatment is of great significance in delaying disease progression, thereby delaying or even av...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/02A61L27/04A61L27/06A61L27/12A61L27/18A61L27/20A61L27/24A61L27/56A61L27/58B33Y70/00B33Y70/10
CPCA61L27/06A61L27/04A61L27/025A61L27/12A61L27/222A61L27/20A61L27/22A61L27/24A61L27/18A61L27/56A61L27/58B33Y70/00B33Y70/10A61L2430/02C08L89/00
Inventor 钱文伟朱诗白张啸天陈曦王一鸥李姗妮
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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