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Application of compound medicine in preparation of medicine for preventing/treating MAFLD

A drug and compound technology, which is applied in the application field of compound drugs in the preparation of drugs for the prevention/treatment of metabolic-related fatty liver disease, can solve the problems of high recurrence rate, difficult and effective cure of drugs, and large side effects, and achieve the adjustment of lipid metabolism Abnormalities, overcoming adverse drug reactions, and improving insulin resistance

Pending Publication Date: 2022-05-24
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, the treatment measures for MAFLD were mainly divided into four categories: ①Exercise therapy, the disadvantage is that it is difficult to persist and cannot completely control the development of the disease; ②Surgical treatment (bariatric surgery and liver transplantation), the disadvantage is that the cost is high and the recurrence rate is high; ③Diet therapy , the disadvantage is that there is no exact MAFLD diet treatment plan, and the therapeutic effect is not easy to be repeated in clinical practice
④Drug therapy, the disadvantage is that the main clinically used drugs (heteridines, thiazolidinediones) cannot eradicate the inflammatory response induced by lipid peroxidation, and these drugs will cause relatively large side effects when taken for a long time
Since the onset of MAFLD is caused by the simultaneous abnormality of multiple signaling pathways, drugs targeting a single signaling pathway are difficult to cure effectively and are prone to drug resistance

Method used

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  • Application of compound medicine in preparation of medicine for preventing/treating MAFLD
  • Application of compound medicine in preparation of medicine for preventing/treating MAFLD
  • Application of compound medicine in preparation of medicine for preventing/treating MAFLD

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment of the present invention 1: the preparation and application of compound medicine:

[0037] In parts by weight, take 50 parts of Ginkgo biloba, 50 parts of Salvia miltiorrhiza, 30 parts of Asarum radix, 30 parts of Gynostemma pentaphyllum, 40 parts of hawthorn, 40 parts of garlic, 20 parts of Panax notoginseng and 10 parts of mugwort tablets, and add 60% of 10 times the weight. Ethanol, reflux extraction for 2h, filter, combine the filtrate, concentrate the filtrate to a clear paste with a relative density of 1.13-1.15 at 50°C, spray-dry it, and pack it into capsules to make capsules; the obtained capsules can be directly used for the prevention / treatment of metabolic related fatty liver disease. Dosage: Oral, 2-4 capsules at a time, 3 times a day.

Embodiment 2

[0038] Embodiment 2: the preparation and application of compound medicine:

[0039] In parts by weight, take 25 parts of ginkgo biloba, 60 parts of Salvia miltiorrhiza, 15 parts of Asarum radix, 15 parts of Gynostemma pentaphyllum, 20 parts of hawthorn, 20 parts of garlic, 10 parts of Panax notoginseng and 20 parts of mugwort, add 5 times the weight of 80% Ethanol, reflux extraction for 4 times, 0.5h each time, filter, combine the filtrates, concentrate the filtrate to a clear paste with a relative density of 1.25-1.30 at 80°C, add an appropriate amount of starch and xylitol, mix well, granulate, dry, It is made into granules; the obtained granules can be directly used for the prevention / treatment of metabolic-related fatty liver disease. Dosage: Oral, 1-2 packs (0.5g per pack) at a time, 3 times a day.

Embodiment 3

[0040] Embodiment 3: the application of compound medicine:

[0041] Take 40 parts of Ginkgo biloba, 50 parts of Salvia miltiorrhiza, 40 parts of Dengzhan Asarum, 40 parts of Gynostemma pentaphyllum, 50 parts of hawthorn, 50 parts of garlic, 30 parts of Panax notoginseng and 5 parts of mugwort. Add 15 times by weight of 50% ethanol, reflux for extraction twice, 3h each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to obtain a concentrated solution for use. The concentrated solution is dissolved in distilled water, an appropriate amount of flavoring agents and preservatives are added, and then filtered, and the pH value is adjusted to prepare an oral solution; the obtained oral solution can be directly used for the prevention / treatment of metabolic-related fatty liver disease. Dosage: Oral, 3-6ml or 1-2 bottles at a time (3ml per bottle), 2-3 times a day.

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Abstract

The invention discloses an application of a compound medicine in preparation of a medicine for preventing / treating MAFLD. The compound medicine is prepared from ginkgo leaves, salvia miltiorrhiza, erigeron breviscapus, gynostemma pentaphylla, hawthorn, garlic, pseudo-ginseng and blumea balsamifera. The compound medicine takes salvia miltiorrhiza as a monarch drug to achieve the effects of promoting blood circulation to remove blood stasis, takes ginkgo leaves as a ministerial drug to achieve the effects of protecting liver and reducing lipid, takes gynostemma pentaphylla and pseudo-ginseng as adjuvant drugs to achieve the effects of nourishing heart and tranquilizing mind, and takes erigeron breviscapus, hawthorn, lotus leaf and blumea balsamifera as conductant drugs to achieve the effects of clearing turbidity, detoxifying and promoting intestinal tract movement; multi-way and multi-target regulation and control can be carried out on key links of MAFLD, and occurrence and development of the MAFLD disease course are effectively regulated and controlled by improving insulin resistance, adjusting abnormal lipid metabolism and reducing the content of inflammatory factors IL-6 and TNF-alpha; meanwhile, the defects of high cost and adverse drug reaction caused by western medicine combined treatment are overcome, and the pharmaceutical composition is convenient to use, safe and effective, and provides a new choice for clinical medication for preventing / treating MAFLD diseases.

Description

technical field [0001] The invention belongs to the technical field of new uses of traditional Chinese medicines, in particular to the application of a compound medicine in the preparation of medicines for preventing / treating metabolism-related fatty liver disease. Background technique [0002] Metabolic-dysfunction-associated fatty liver disease (MAFLD) is caused by alcohol and other definite liver damage factors, mainly manifested as diffuse hepatocyte bullous steatosis and lipid metabolism disorder. The clinicopathological syndrome characterized by inflammation induced by lipid peroxidation and lipid peroxidation has now surpassed viral hepatitis as the first major liver disease in the world. If uncontrolled, MAFLD can further develop into non-alcoholic steatohepatitis, fatty liver fibrosis, liver cirrhosis and even liver cancer. At the same time, MAFLD is also one of the main causes of cardiovascular and cerebrovascular diseases, diabetes, heart disease, chronic kidney ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P1/16A61P5/50A61P29/00A61P3/00
CPCA61K36/16A61K36/537A61K36/28A61K36/424A61K36/734A61K36/8962A61K36/258A61P1/16A61P5/50A61P29/00A61P3/00A61K2236/333A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 黄磊李艳梅胡安玲饶青宋晶睿黄裕兵王琨吴小森李静
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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