Flexible inorganic nanofiber composite scaffold and preparation method thereof

A technology of inorganic nanofibers and composite scaffolds, which can be used in pharmaceutical formulations, prostheses, and drug delivery. It can solve the problems of short duration of anti-inflammatory and antibacterial effects of nanofiber scaffolds, and achieve long anti-inflammatory and antibacterial effects, slow degradation, and sustained long time effect

Pending Publication Date: 2022-06-07
诺一迈尔(苏州)生命科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Due to the faster degradation of organic nanofiber scaffolds, the release rate of copper ions in organic nanofiber scaffolds used in the field of wound repair is faster, so that the duration of anti-inflammatory and antibacterial effects of nanofiber scaffolds is shorter

Method used

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  • Flexible inorganic nanofiber composite scaffold and preparation method thereof
  • Flexible inorganic nanofiber composite scaffold and preparation method thereof
  • Flexible inorganic nanofiber composite scaffold and preparation method thereof

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preparation example Construction

[0031] In order to solve the problem of short duration of anti-inflammatory and antibacterial effects of the existing nanofiber scaffolds used in the field of wound wound repair, the present invention provides a preparation method of a flexible inorganic nanofiber composite scaffold, the preparation method comprising the following steps:

[0032] S1: Prepare a precursor solution with ethyl orthosilicate, deionized water and phosphoric acid as raw materials;

[0033] S2: adding antibacterial salt to the precursor solution, mixing and stirring at room temperature to obtain a mixed salt-doped solution;

[0034] S3: using polyvinyl alcohol as a template agent to prepare a template agent aqueous solution;

[0035] S4: mixing the salt-doped mixed solution with the template agent aqueous solution, and stirring at room temperature to obtain an electrospinning solution;

[0036] S5: spinning the electrospinning solution by an electrospinning process to obtain a nanofiber membrane;

...

Embodiment 1

[0056] The present embodiment provides a method for preparing a flexible inorganic nanofiber composite scaffold, comprising the following steps:

[0057] S1: Mix ethyl orthosilicate, deionized water and phosphoric acid with a molar ratio of 1:11:0.01, and stir for 24h to prepare a precursor solution;

[0058] S2: add 50 mg of copper chloride to 10 g of the precursor solution, mix and stir at room temperature to obtain a copper-doped mixed solution;

[0059] S3: Dissolve 2 g of polyvinyl alcohol in 18 g of deionized water, and stir at room temperature for 24 h to prepare an aqueous template agent;

[0060] S4: mixing the copper-doped mixed solution with the template aqueous solution of equal mass, and stirring at room temperature to obtain an electrospinning solution;

[0061] S5: spin the electrospinning solution by using the electrospinning process, set the electrospinning high voltage to 20kV, the propulsion speed of the propulsion pump to be 2mL / h, and use the non-woven fa...

Embodiment 2

[0070] The present embodiment provides a method for preparing a flexible inorganic nanofiber composite scaffold, comprising the following steps:

[0071] S1: Mix ethyl orthosilicate, deionized water and phosphoric acid with a molar ratio of 1:11:0.01, and stir for 24h to prepare a precursor solution;

[0072] S2: add 100 mg of copper chloride to 10 g of the precursor solution, mix and stir at room temperature to obtain a copper-doped mixed solution;

[0073] S3: Dissolve 2 g of polyvinyl alcohol in 18 g of deionized water, and stir at room temperature for 24 h to prepare an aqueous template agent;

[0074] S4: mixing the copper-doped mixed solution with the template aqueous solution of equal mass, and stirring at room temperature to obtain an electrospinning solution;

[0075] S5: spin the electrospinning solution by using the electrospinning process, set the electrospinning high voltage to 20kV, the propulsion speed of the propulsion pump to be 2mL / h, and use the non-woven f...

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Abstract

The invention provides a flexible inorganic nanofiber composite scaffold and a preparation method thereof. The preparation method comprises the following steps: preparing a precursor solution; adding antibacterial salt into the precursor solution to obtain a salt-doped mixed solution; preparing a template agent aqueous solution; mixing the salt-doped mixed solution with a template agent aqueous solution to obtain an electrostatic spinning solution; spinning the electrostatic spinning solution to obtain a nanofiber membrane; and calcining the nanofiber membrane to obtain the flexible inorganic nanofiber composite scaffold. According to the preparation method of the flexible inorganic nanofiber composite scaffold, inorganic components serve as raw materials, the prepared nanofiber composite scaffold does not contain organic components, and compared with an existing organic nanofiber scaffold, the degradation speed is low, antibacterial components can be released for a long time, and the flexible inorganic nanofiber composite scaffold is good in antibacterial effect. The prepared flexible inorganic nanofiber composite scaffold can maintain long-term biological activity, so that the duration of the anti-inflammatory and antibacterial effects of the flexible inorganic nanofiber composite scaffold is long.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a flexible inorganic nanofiber composite scaffold and a preparation method thereof. Background technique [0002] Tissue engineering scaffolds are places where cells live, proliferate and differentiate. Electrospinning technology is an effective means of preparing tissue engineering scaffolds. It has a simple and efficient preparation method, and can prepare fibers in the nanometer to micrometer diameter range, imitating natural fibers. extracellular matrix, etc. [0003] In the field of tissue engineering repair of skin wounds, effectively inhibiting the growth of bacteria during the repair process is crucial for the timely repair of wounds. Bacterial growth can cause inflammation, wound ulceration, tissue necrosis, and delayed wound healing. Copper ions have certain anti-inflammatory and antibacterial effects, and have excellent inhibitory effects on bacterial gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/60A61L27/50A61L27/02D04H1/728D04H1/4309
CPCA61L27/54A61L27/60A61L27/50A61L27/025D04H1/728D04H1/4309A61L2400/12A61L2300/404A61L2300/41A61L2300/602A61L2300/102
Inventor 莫秀梅潘信崔洁
Owner 诺一迈尔(苏州)生命科技有限公司
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