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Melanin metabolic enzyme composition for fading stains and preparation method of melanin metabolic enzyme composition

A technology for lightening spots and melanin, which is applied in the composition and preparation of melanin metabolizing enzymes, which can solve the problems of potential safety hazards and large side effects, and achieve the effect of easy operation, lightening spots, and mild and non-irritating skin

Pending Publication Date: 2022-08-05
杭州芙因生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Various whitening and freckle-removing products are emerging in the market, but many products have safety hazards, such as adding hormones, etc., and long-term use has serious side effects

Method used

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  • Melanin metabolic enzyme composition for fading stains and preparation method of melanin metabolic enzyme composition
  • Melanin metabolic enzyme composition for fading stains and preparation method of melanin metabolic enzyme composition
  • Melanin metabolic enzyme composition for fading stains and preparation method of melanin metabolic enzyme composition

Examples

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Effect test

Embodiment 1

[0032] This example provides a melanin metabolizing enzyme composition for lightening pigmentation spots. The composition includes, in parts by weight, 15 parts of melanin degrading enzyme, 5 parts of small molecular polysaccharide, 3 parts of nine peptides-1, pro- 10 parts of aqueous solubilizer and 65 parts of water-soluble matrix material.

[0033] Melanin degrading enzyme is obtained by fermentation of Japanese golden koji.

[0034] Small molecular polysaccharides include erythritol and trehalose with a molecular weight of ≤500 and a mass ratio of 1:2.

[0035] The hydrophilic solubilizer was arginine and lysine in a mass ratio of 1:2.

[0036] The water-soluble matrix materials are sodium hyaluronate, dextran and collagen in a mass ratio of 1:1:10.

Embodiment 2

[0038] This embodiment provides a melanin metabolizing enzyme composition for lightening pigmentation spots. The composition includes, in parts by weight, 20 parts of melanin degrading enzyme, 8 parts of small molecular polysaccharide, 4 parts of acetyl tetrapeptide-5, 12 parts of hydrophilic solubilizer and 30 parts of water-soluble matrix material.

[0039] The melanin degrading enzyme is obtained by fermentation of a combination of Aspergillus oryzae and Saccharomyces cerevisiae.

[0040] The small molecular polysaccharides include dendrobium polysaccharides and tervain in a mass ratio of 1:1.

[0041] The hydrophilic solubilizer is stachydine.

[0042] The water-soluble matrix material is sodium hyaluronate.

Embodiment 3

[0044] This embodiment provides a melanin metabolizing enzyme composition for lightening pigmentation spots. The composition includes, in parts by weight, 30 parts of melanin degrading enzyme, 10 parts of small molecular polysaccharide, 5 parts of hexapeptide-2, hydrophilic 15 parts of the solubilizer and 50 parts of the water-soluble matrix material.

[0045] Small molecule peptides include one or more combinations of Tetrapeptide-30, Nonapeptide-1, Acetyl Tetrapeptide-5 or Dipeptide-2.

[0046] Melanin degrading enzyme is obtained by fermentation of Saccharomyces cerevisiae.

[0047] Small molecular polysaccharides include Bletilla striata polysaccharides with a molecular weight of ≤500.

[0048] The hydrophilic solubilizer is L-carnitine.

[0049] The water-soluble matrix material is polyvinyl alcohol.

[0050] Blank control group: the only difference from Example 1 is that no melanin degrading enzyme is added.

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Abstract

The invention discloses a melanin metabolic enzyme composition for fading stains and a preparation method thereof. The melanin metabolic enzyme composition comprises melanin degrading enzyme, small molecule polysaccharide and small molecule peptide. According to the melanin metabolic enzyme composition for fading the color spots, provided by the invention, the melanin metabolic enzyme contains various active enzymes and bioactive factors related to melanin degradation, so that melanin degradation is quickly promoted, pigments are removed, and the skin color is brightened and whitened; the micromolecular polysaccharide moistens the skin and provides oxidation resistance; the small molecule peptide rapidly permeates the skin to improve the skin elasticity; the composition can rapidly recognize melanin, rapidly degrade melanin and decompose melanin into simple amino acid to promote metabolism, all the components in the composition act synergistically, the effects of fading stains, whitening skin and improving skin elasticity are effectively achieved, and the composition is mild and non-irritant to skin.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition and a preparation method of a melanin metabolizing enzyme for lightening pigmentation. Background technique [0002] Fair skin has always been the pursuit of many beauty lovers, and it has always been an important issue in beauty to have fair skin. The color of human skin is determined by many factors, but mainly depends on the content and distribution of melanin. [0003] Pigmentation is caused by the increase of melanin in the skin, mostly on the cheeks and forehead, and is aggravated by sun exposure. Melanin is produced by melanosomes, a small cellular organ in the pigment cells of the basal layer of the epidermis, then moves to the epidermal cells, enters the stratum corneum while decomposing in the epidermal cells, and finally disappears from the skin together with the exfoliated fragments of the keratinocytes. The role of melanin is to protect t...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/66A61K8/64A61Q19/02A61Q19/08A61Q19/00
CPCA61K8/73A61K8/66A61K8/64A61Q19/02A61Q19/08A61Q19/00A61K2800/592
Inventor 杨旭静
Owner 杭州芙因生物科技有限公司
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