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Liposome anti-fungus medication sprayer formulation

A technology of antifungal drugs and sprays, which is applied in the field of medicine, can solve problems such as inability to eradicate patients, and achieve the effects of enhancing drug action time, avoiding irritation, and reducing irritation

Inactive Publication Date: 2005-12-28
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current clinically used beriberi medicines cannot penetrate the cuticle of the skin and reach the lesion, so they cannot eradicate the disease.

Method used

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  • Liposome anti-fungus medication sprayer formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: Contain 0.1% mole miconazole nitrate in the drug liposome product.

[0053] name

[0054] Add the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil into 20ml of ethanol, heat to 45°C and stir to dissolve completely. Then slowly add the ethanol drug solution into 180ml of pure water stirred at a high speed (3000r / min) by a shearing machine, and continue to stir for 30min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized 7 times by a high-pressure homogenizer, and the pressure was 100 MPa. During the homogenization process, the temperature should not exceed 60°C to obtain a large single-chamber single-phase liposome drug solution with a particle size of 250nm ± 40nm. The final product after dilution is a uniform milky solution without precipitation and stratification. Store the product at 2°C-15°C and dark ...

Embodiment 2

[0055] Embodiment 2: Contain 15% mole miconazole nitrate in the drug liposome product.

[0056] name

molecular weight

Mole (%)

Feed amount (g)

Lecithin

760

74.0

18.7

cholesterol

386.66

7.5

1.3

miconazole nitrate

479.15

15.0

2.4

Oleic acid

282

3.0

0.3

Azone

281

0.1

0.01

Vitamin E

472

0.2

0.03

peppermint oil

0.2

0.3

[0057] Add 40ml of ethanol to the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil, heat and stir until completely dissolved. Slowly add the ethanol drug solution into 160ml of pure water stirred at high speed (3000r / min) by a shearing machine, and continue to stir for 35min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized 6 tim...

Embodiment 3

[0059] Embodiment 3: Contain 7% mole miconazole nitrate in the drug liposome product.

[0060] name

molecular weight

Mole (%)

Feed amount (g)

Lecithin

760

82.0

19.11

cholesterol

386.66

7.5

0.89

miconazole nitrate

479.15

7.0

0.10

Oleic acid

282

3.0

0.3

Azone

281

0.1

0.01

Vitamin E

472

0.2

0.03

peppermint oil

0.2

0.3

[0061] Add the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil into 30ml of ethanol, heat to 45°C and stir to dissolve completely. Slowly add the ethanol drug solution into 170ml of pure water stirred at a high speed (3000r / min) by a shearing machine, and continue stirring for 30min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogen...

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Abstract

The invention discloses a liposomal antifungal drug spray preparation, which comprises the following main components: antifungal chemically synthesized drug, liposome packaging material, transdermal absorption penetration enhancer and skin protection agent lecithin, lipid Cholesterol for body packaging materials, oleic acid for liposome packaging materials and transdermal penetration enhancers, transdermal penetration enhancers, vitamin E for antioxidants and skin protectants, ethanol and transdermal penetration enhancers for transdermal absorption Natural essential oils for absorption enhancers, antibacterial natural remedies and fragrances. The liposomal antifungal drug spray preparation is prepared by all or part of the above compounds, and the water solubility of the oil-soluble antifungal drug and the dissolution and uniformity of the drug in water are well solved by liposome encapsulation, which enhances the drug Transdermal absorption and sending the drug into the dermis to improve the efficacy of the drug, avoiding the use of co-solvents with side effects, so as to reduce the toxic side effects and skin irritation caused by the drug entering the blood circulation system of the whole body, and it has the effect of protecting and beautifying the skin effect.

Description

1. Technical field [0001] The invention belongs to the field of medicine, and relates to an antifungal medicine spray preparation, in particular to a liposome antifungal medicine spray preparation. 2. Background technology [0002] Athlete's foot, also known as Hong Kong's athlete's foot. Traditional Chinese medicine believes that the main symptoms of this disease are numbness, soreness and weakness of the shins. According to its symptoms, it is mainly divided into dry beriberi, wet beriberi and beriberi rushing to the heart. At the beginning, dizziness and fatigue, fatigue and anorexia, pinpricks or ants crawling on the feet, distributed in a sock-like distribution, followed by muscle soreness, muscle weakness, skin dullness, muscle relaxation, contracture, and foot edema. In severe cases, palpitations, shortness of breath, tachycardia, enlarged heart, swelling and pain in the lower limbs, when the swelling and pain extend from the knee to the thigh, confusion, wheezing a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/12A61K9/127A61K31/4164A61K31/4196A61K31/496A61P31/10
Inventor 陈涛惠民权王九成
Owner XIAN LIBANG PHARMA TECH
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