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Method for preparing nano-microballons of Avermectins medicine and usage

A technology of nano-microspheres and abamectin, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., which can solve the problems of low bioavailability, low toxicity, residual effect, restrictions on large-scale promotion and use, and soil ecology. Large environmental impact and other issues, to achieve the effect of solving soil ecological problems, increasing the duration of drug effects, and reducing the amount of drugs

Inactive Publication Date: 2006-08-30
方淑昌 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a drug in vivo, the effective blood drug concentration only maintains about 68 hours, and the bioavailability is as low as 20%-30%. As a pesticide, there are toxicity and residual effects, which have a great impact on the soil ecological environment, and poor stability, low efficacy, Problems such as high cost limit the large-scale promotion and use of this biopesticide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, the preparation method of avermectins and its derivatives ivermectin and nano-microspheres, the processing steps are:

[0019] A, use biodegradable polylactic acid-co-glycolic acid copolymer (Poly lactic acid-co-glyclic acid, PLGA) as the carrier material, weigh the corresponding proportion with the drug contained in it (content 1%-40%), add dichloro A mixed solvent of methane and acetone makes it dissolve;

[0020] B, preparation concentration is the polyvinyl alcohol (PVA) aqueous solution of 1%-6% concentration, PLGA solution is dispersed in the aqueous solution of PVA with ultrasonic emulsifier, forms oil-in-water emulsion;

[0021] C, after vacuumizing the oil-in-water emulsion under constant stirring to remove the organic solvent for 10-24 hours, the prepared nanospheres are solidified;

[0022] D. Centrifuge the solidified nano-microspheres in a low-temperature ultracentrifuge at a speed of 10,000-40,000 rpm, centrifuge for 20-30 minutes, and colle...

Embodiment 2

[0035] Embodiment 2, preparation method, on the basis of embodiment 1, the microsphere of the pharmaceutical dosage form that embeds is below 150nm.

Embodiment 3

[0036] Embodiment 3, preparation method, on the basis of embodiment 1, the microspheres of the pesticide formulation embedded in the microsphere carrier material are below 250nm.

[0037] The use of the nanometer microspheres is to treat parasitic infections of humans and animals through intramuscular injection of humans or animals, and to prevent and control crop diseases and insect pests.

[0038]The polylactic acid-polyglycolic acid copolymer used in the drug sustained-release matrix is ​​a biodegradable material, and it can be hydrolyzed non-enzymatically in humans and animals, completely compatible with blood, and slowly hydrolyzed in the body to be harmless to the human body. The lactic acid and glycolic acid are finally decomposed into carbon dioxide and water. Abamectin drug nanospheres prepared by ultrasonic emulsification solvent volatilization method is to place the abamectin or ivermectin coating part inside the controlled-release carrier particle, so that the drug...

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PUM

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Abstract

A nanosphere of abamectin used as both medicine and agricultural chemical is prepared through preparing the polylactic acid-polyglycollic acid copolymer (PLGA), mixing abemectin with PLGa, ultrasonic emulsifying, volatilizing solvent, supersonic centrifugal treating, mixing, concentrating, leaching with distilled water, and supersonic centrifugal treating, mixing, concentrating again, and freeze drying at -106- -108 deg.C. Its advantages are slow release, low poison and low cost.

Description

technical field [0001] The invention relates to a preparation method and application of abamectin drug and its derivative ivermectin slow-release nano-microspheres. technical background [0002] Avermectins are currently the most excellent class of broad-spectrum and high-efficiency antiparasitic drugs, and are also the fastest growing and most widely used biomedicine and pesticides in the world. However, as a drug in vivo, the effective blood drug concentration only maintains about 68 hours, and the bioavailability is as low as 20%-30%. As a pesticide, there are toxicity and residual effects, which have a great impact on the soil ecological environment, and poor stability, low efficacy, Problems such as high cost limit the large-scale promotion and use of this biological pesticide. Contents of the invention [0003] The object of the present invention is to aim at above-mentioned drawback of prior art, provide a kind of adopting biodegradable polymer material polylactic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/14A61K9/50A61P33/00
Inventor 方淑昌于美丽
Owner 方淑昌
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