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Fungicide, composition thereof, use and fungicidal method thereof

A technology of bactericide and composition, which is applied in the field of inhibiting microbial reproduction, and can solve the problems of not using preservatives or bactericides

Inactive Publication Date: 2003-03-12
AJINOMOTO CO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, aminoguanidine-containing derivatives or salts thereof are known to be used as texture modifiers in hair cosmetic materials and skin external preparations, but it has not been used as a preservative or bactericide, or has not been studied as a preservative or bactericide , and practically no known examples of aminoguanidine-containing derivatives or their salts being used in wet tissue products or oral preparations

Method used

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  • Fungicide, composition thereof, use and fungicidal method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] The present invention is further illustrated by way of comparison and examples.

[0115] (1) Synthesis of amidoguanidine-containing derivatives

[0116] 180 g of water and 110 g of 2-propanol were added to 52.7 g (0.23 mol) of 4-aminobutylguanidine sulfate. The pH of the system was adjusted to 11.0 with 27% sodium hydroxide aqueous solution, and the temperature was adjusted to 10°C. In this system, 50.3 g (0.23 mol) of lauroyl chloride was added dropwise within 35 minutes. During this period of time, the temperature of the system was maintained at 8-12°C, and the pH value was maintained at 10.9-11.0 with a 27% aqueous sodium hydroxide solution. After completion of the dropwise addition, the reaction further matured during 30 minutes.

[0117] After the reaction was completed, the temperature of the system was adjusted to 50°C. The obtained oil phase was separated, the pH was adjusted to 14 with a 27% sodium hydroxide aqueous solution, and cooled to room temperature. After c...

Embodiment 2～5

[0137] In order to evaluate the contribution of the acyl moiety to the antibacterial activity in the amidoguanidine-containing derivatives, 4-guanidinobutyl decacoamide acetate (DAG-AcOH) and 4-guanidinobutyl dodecylamide acetic acid were tested Salt (LAG-AcOH), 4-guanidinobutyl tetradecyl amide acetate (MAG-AcOH), 4-guanidino butyl hexadecyl amide acetate (PAG-AcOH) in each experimental strain Their growth is completely inhibited by their concentration (MIC).

[0138] The experimental strains used are Escherichia coli (ATCC8739), Pseudomonas aeruginosa (ATCC9027), Staphylococcus aureus (ATCC6538), Streptococcus mutans (ATCC35275), Propionibacterium acnes (ATCC6919), Candida albicans (ATCC10231) , Aspergillus niger (ATCC16404), Trichophyton mentagrophytes (ATCC11480), Malassezia saccharomyces (ATCC14521), MRSA and Cladosporium cladosporioides.

[0139] The bacterial cell suspensions of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans mutants, P...

Embodiment 6 and 7

[0153] Example 6

[0154] Example 8

[0155] Prepare the antibacterial cream with the formula shown in Table 7 below (based on the weight% of the net components, and the total weight is 100%). When each of the antibacterial creams thus prepared was used, satisfactory performance was obtained.

[0156] Table 7:

[0157] Example 11

[0158] Example 13

[0159] Example 16

[0160] Example 21

[0161] Example 23

[0162] Example 26

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PUM

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Abstract

A bactericide and an anticeptic comprises at least an amide group-containing guanidine derivative represented by General Formula (I) or a salt thereof: wherein R1 and R2 are same or different and each denotes a hydrogen atom, a straight or branched alkyl group or alkenyl group having 1 to 4 carbon atoms, R3 denotes a straight or branched alkyl group or alkenyl group having 1 to 22 carbon atoms, and A denotes a straight or branched alkylene group or alkenylene group having 1 to 10 carbon atoms.

Description

Invention field [0001] The present invention relates to an antiseptic or bactericide using an amidoguanidine-containing derivative or its salt. In addition, the present invention relates to a skin coating composition, a detergent composition, an antibacterial fiber polymer, a method for killing microorganisms, and a method for inhibiting the reproduction of microorganisms using the preservative and / or bactericide. Background of the invention [0002] Products in conventional aqueous dosage forms, including cosmetic or skin external preparations, such as lotions, emulsions, ointments, face lotions, emulsions and creams, wet tissues and oral compositions, etc. Various preservatives or bactericides are used to prevent any denaturation due to contamination by microorganisms such as bacteria and fungi during production and use, and to kill bacteria and microorganisms present in the oral cavity, skin or hair. [0003] Such preservatives and bactericides used in the above products may b...

Claims

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Application Information

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IPC IPC(8): C07C279/12A01N47/44C11D3/32C11D3/48
CPCC11D3/48A01N47/44C11D3/323C07C279/12
Inventor 弓冈良辅中西纪元横田博史
Owner AJINOMOTO CO INC
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