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Method for producing high-purity capsaicin by using capsicine as raw material

A capsaicin, high-purity technology, applied in the field of purifying and producing high-purity capsaicin, can solve the problems of pollution, low purity of capsaicin, and no recovery.

Inactive Publication Date: 2004-02-25
GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current purification method uses a large amount of organic solvents and does not recycle, which not only causes pollution, but also the resulting capsaicin has a low purity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Capsaicin 1.5g is dissolved in 6ml acetone, the added 15ml 50% silver nitrate solution is complexed for 3 hours at room temperature and pH7, and the stratification is allowed to stand; 15ml sherwood oil is used to process the water phase to remove fat-soluble impurities therein. Then use 20ml of dichloromethane to extract the silver ion complex in the aqueous phase twice; then process the organic phase with 8% hydrochloric acid and saturated sodium chloride solution to remove the silver ion in the silver ion complex, filter Remove the insoluble matter, recover the solvent, and obtain a concentrated solution; completely dissolve the concentrated solution in 10% sodium hydroxide solution, then neutralize it with 2% sulfuric acid, adjust the pH to 7-10, and stand for 10 hours to crystallize. Filter, wash with water, and dry to obtain 0.43 g of white high-purity capsaicin with a recovery rate of 28.7%.

Embodiment 2

[0008] Capsaicin 1.5g is dissolved in 8ml ethanol, adds 10ml 60% silver nitrate solution, complexes at room temperature, pH7 time 2.5 hours, leaves standstill layering; Process water phase with 10ml n-hexane, removes fat-soluble impurity wherein, Then use 15ml of chloroform to extract the silver ion complex in the aqueous phase three times; then process the organic phase with 4% sulfuric acid and saturated potassium chloride solution to remove the silver ion in the silver ion complex, and filter to remove For insoluble matter, recover the solvent to obtain a concentrated solution. The concentrated solution is completely dissolved in 20% potassium hydroxide solution, then neutralized with 2% nitric acid, adjusted to pH 7-10, and left to stand for 30 hours for crystallization. Filter, wash with water, and dry to obtain 0.38 g of white high-purity capsaicin with a recovery rate of 25.3%.

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Abstract

The present invention relates to a method for purifying capsicine. It uses commercial capsaicine as raw material, and adopts the following steps: dissolving capsaicine in hydrophilic organic solvent,and making it implement complexation reaction with aqueous solution containing silver ion, then using hydrophobic organic solvent to treat silver ion complex, after the silver ion is removed, using alkali and acid to treat concentrate, finally, recovering high-purity capsicine.

Description

technical field [0001] The invention relates to a method for purifying and producing high-purity capsaicin by using capsaicin as a raw material. technical background [0002] Capsaicin (Capsaicinoids capsaicinoids) is a very pungent and irritating component in capsicum fruit, consisting of more than 14 vanillyl amides. The chemical name of capsaicin (Capsaicin) is trans-8-methyl N-vanillyl-6-nonenamide, which is one of the three main components in capsaicin, and the other two main components are dihydrocapsaicin (Dihydrocapsaicin) and Nordihydrocapsaicin. The main use of capsaicin in medicine is for analgesia, especially for the treatment of postherpetic neuralgia, diabetic neuralgia, rheumatoid arthritis and osteoarthritis pain, and the effect is obvious; it can also be used for the treatment of Skin itching and other diseases; low doses of capsaicin can promote the secretion of saliva and gastric acid, as an oral agent can play a role in promoting digestion; as an antiox...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C233/18
Inventor 曾祥英盛国英胡成一傅家谟
Owner GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
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