Process for preparing gliclazide slow release capsule for oral sugar reducing method
A technology of gliclazide and sustained-release capsules, applied in the field of medicine, can solve the problems such as no research report on hydrophilic gel sustained-release capsules, and reduce the number of times of taking medicines, so as to reduce the times of medication, reduce the cost of treatment, and reduce the dose. Effect
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Embodiment 1
[0013] Gliclazide sustained-release capsules of the present invention consist of (percentage by weight, the same below): 10% of gliclazide, 70% of calcium hydrogen phosphate, 15% of HPMC100cp, 1% of EC100cp, 2% of magnesium stearate, 2% of talcum powder %.
[0014] The preparation method is as follows: pass the prescription amount of gliclazide, calcium hydrogen phosphate, HPMC 4000cp, HPMC 100cp and EC 100cp through a 100-mesh sieve respectively, mix them in a mixer, add 50% ethanol aqueous solution as a wetting agent and stir Make soft material, granulate through 14 mesh sieve, dry granules at 50°C for 1.5 hours, granulate with 14 mesh sieve, add magnesium stearate and talcum powder in prescribed amount, mix evenly, pack into capsules.
[0015] Implementation Effect:
[0016] The resulting granules were relatively hard, with a content of 0.172 g. According to the Chinese Pharmacopoeia 2000 Edition II Fuling regulations capsule inspection items, the weight difference meets ...
Embodiment 2
[0018] The gliclazide sustained-release capsules of the present invention consist of 15% gliclazide, 60% calcium hydrogen phosphate, 14.8% HPMC4000cp, 5% HPMC 100cp, 5% EC100cp, 0.1% magnesium stearate and 0.1% talcum powder.
[0019] The preparation method is: pass the prescription amount of gliclazide, calcium hydrogen phosphate, HPMC 4000cp, HPMC 100cp and EC 100cp through 80 mesh sieve respectively, put it in a mixer and mix well, add 60% ethanol aqueous solution as a wetting agent and stir Made into a soft material, granulated through a 16-mesh sieve, dried at 60°C for 1 hour, granulated through a 16-mesh sieve, then added with prescribed amounts of magnesium stearate and talcum powder, mixed evenly, and packed into capsules.
[0020] Implementation Effect:
[0021] Closer granules were produced with a content of 0.170 g. According to the Chinese Pharmacopoeia 2000 Edition II Fuling regulations capsule inspection items, the weight difference meets the requirements. Acco...
Embodiment 3
[0023] The composition of the gliclazide sustained-release capsule of the present invention is as follows: 25% of gliclazide, 48% of calcium hydrogen phosphate, 10% of HPMC4000cp, 7.5% of HPMC100cp, 7% of EC100cp, 1.5% of magnesium stearate, and 1% of talcum powder.
[0024] The preparation method is: pass the prescription amount of gliclazide, calcium hydrogen phosphate, HPMC 4000cp, HPMC 100cp and EC 100cp through an 80-mesh sieve respectively, mix them in a mixer, add 70% ethanol aqueous solution as a wetting agent and stir Make soft material, granulate through 18 mesh sieve, dry granule at 50°C for 2 hours, granulate with 18 mesh sieve, add magnesium stearate and talcum powder in prescribed amount, mix well, pack into capsules.
[0025] Implementation Effect:
[0026] Regular granules were obtained with a content of 0.162 g. According to the Chinese Pharmacopoeia 2000 Edition II Fuling regulations capsule inspection items, the weight difference meets the requirements. Ac...
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