Process for preparing bis-phenyl fluorozine and its use as medicine in treatment of cardiovascular and cerebrovascular diseases

A technology of difluzine and benzhydrylpiperazine, which is applied in the field of preparation of difluzine, can solve problems such as heart damage and cerebrovascular stealing, and achieve the effects of increasing yield, simplifying process, and qualified quality
CN1654461AInactive Publication Date: 2005-08-17HEBEI MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEBEI MEDICAL UNIVERSITY
Publication Date
2005-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the preparation process of diphenyl ofloxacin and its application in preparing medicine for treating cardiac and cerebral vascular diseases. The preparation process includes the following steps: A) preparing gamma-chloro-4-fluorobenzene-1-butanone through the reaction between gamma-butyrolactone and sulfoxide chloride to obtain gamma-butyryl chloride and the subsequent reaction in mixed solvent with catalyst; B) preparing benzhydryl piperazine through the reaction between diphenylcaabinol and concentrated hydrochloric acid to obtain diphenyl chloromethane, the subsequent reaction in mixed solvent with catalyst and filtering; and C) preparing the product diphenyl ofloxacin with proper amount of benzhydryl piperazine, gamma-chloro-4-fluorobenzene-1-butanone, solvent methyl isobutyl ketone and catalyst potassium iodide and potassium carbonate, and through mixing and reaction.
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Description

technical field

[0001] The invention relates to a preparation method of difluzine, and also relates to the application of the difluzine prepared by the preparation method in the preparation of medicines for preventing and treating cardiovascular and cerebrovascular diseases of mammals and humans. Background technique

[0002] Cardiovascular and cerebrovascular diseases pose a serious threat to human health and even life safety. Cardiovascular and cerebrovascular diseases have been one of the diseases with the highest mortality rate in various diseases for many years. In order to solve the patient's suffering and save the patient's life, people have paid a great price to carry out various attempts. Therefore, seeking effective drugs for the treatment of cardiovascular and cerebrovascular diseases has always attracted the attention of people from all walks of life. The chemical and medical circles are particularly concerned. Although many medicines for the treatment of thes...

Claims

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