Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Disintegration piece of omeprazole and ramification taken through oral cavity and jpreparing technique

A technology for orally disintegrating tablets and omeprazole is applied in the field of orally disintegrating tablets, and can solve the problems such as the preparation prescription and preparation method of the orally disintegrating tablets are not fully disclosed.

Active Publication Date: 2005-08-31
COSCI MED TECH CO LTD
View PDF9 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing references do not fully disclose a preparation prescription and preparation method of orally disintegrating tablets of omeprazole and derivatives thereof identical or similar to the present invention

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1. Prescription

[0068] Name of raw material Amount (g)

[0069] Core Omeprazole Magnesium 200.00

[0070] Magnesium hydroxide 50.00

[0071] Lactose 50.00

[0072] Powder coating layer Hydroxypropyl methylcellulose 30.00

[0073] Sodium Lauryl Sulfate 3.00

[0074] Talc 6.00

[0075] 50% ethanol solution 561.00

[0076] Total 600.00

[0077] Protective coating Hydroxypropyl methylcellulose 33.90

[0078] Mannitol 20.00

[0079] Dimethicone emulsion (dry weight) 2.00

[0080] Pure water 622.10

[0081] Total 678.00

[0082] Enteric layer Eudragit  L100-55 552.86

[0083] Triethyl citrate 71.08

[0084] Talc 12.47

[0085] 95% ethanol solution 2363.59

[0086] Total 3000.00

[0087] Outer protective layer Hydroxypropyl cellulose 32.22

[0088] Stearyl Polyglycerol 3.00

[0089] Mannitol 120.47

[0090] Pure water 544.31

[0091] Total 700.00

[0092] Tablet Coated powder as above 800.00

[0093] Mannitol 970.00

[0094] Methylcellulose 160.00

...

Embodiment 2

[0107] 1. Prescription

[0108] Name of raw material Amount (g)

[0109] Core layer Omeprazole 200.00

[0110] Magnesium hydroxide 70.00

[0111] Microcrystalline Cellulose 75.00

[0112] Lactose 45.00

[0113] Hydroxypropyl methylcellulose 8.00

[0114] Sodium Lauryl Sulfate 2.00

[0115] Pure water Q.S.

[0116] Total 400.00

[0117] Isolation layer Hydroxypropyl methylcellulose 40.00

[0118] Dimethicone emulsion (dry weight) 2.00

[0119] Talc 2.00

[0120] Pure water 756.00

[0121] Total 800.00

[0122] Enteric layer Eudragit  L3OD-55 (dry weight) 87.02

[0123] Eudragit  NE3OD (dry weight) 21.76

[0124] Triethyl citrate 46.42

[0125] Talc 7.77

[0126] 95% ethanol solution 1837.03

[0127] Total 2000.00

[0128] Outer protective layer Hydroxypropyl cellulose 30.35

[0129] Stearyl Polyglycerol 3.00

[0130] Mannitol 159.68

[0131]Pure water 1406.97

[0132] Total 1600.00

[0133] Tablet Coated pellet core as above 800.00

[0134] Mannitol 1...

Embodiment 3

[0156] 1. Prescription

[0157] Layer name Raw material name Amount (g)

[0158] Ball core sugar ball core (80 mesh) 100.00

[0159] Drug Layer Omeprazole Sodium 200.00

[0160] Arginine 10.00

[0161] Hydroxypropyl cellulose 50.00

[0162] Pure water 440.00

[0163] Total 700.00

[0164] Isolation layer Hydroxypropyl methylcellulose 36.00

[0165] Talc 1.85

[0166] Magnesium stearate 0.15

[0167] Pure water 682.00

[0168] Total 720.00

[0169] Enteric layer Eudragit  L100-55 78.01

[0170] Eudragit  NE3OD (dry weight) 19.50

[0171] Triethyl citrate 41.79

[0172] Talc 7.33

[0173] 95% ethanol solution 1843.37

[0174] Total 1990.00

[0175] Outer protective layer Hydroxypropyl methylcellulose 49.02

[0176] PEG6000 5.45

[0177] Dimethicone emulsion (dry weight) 1.20

[0178] Mannitol 159.71

[0179] Pure water 1084.63

[0180] Total 1300.00

[0181] Tablet Coated pellet core as above 760.00

[0182] Mannitol 1539.00

[0183] Microcrystalline C...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Hardnessaaaaaaaaaa
Login to View More

Abstract

An orally-disintegrating tablet of omeprazole and its derivative is prepared from omeprazole and its derivative, coating, filler, disintegrant, flavouring, flowing aid, lubricant and optional plasticizer. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a kind of omeprazole (5-methanol) suitable for treating diseases such as gastric ulcer, duodenal ulcer, stress ulcer, reflux esophagitis and Zollinger-Ellison syndrome (gastrinoma). Oxygen-2-{[(4-methoxy-3,5-dimethyl-2-pyridyl)-methyl]-sulfoxide}-1H-benzimidazole) and omeprazole derivatives Orally disintegrating tablet. The invention also contemplates the preparation method of the preparation. Background technique [0002] Omeprazole is a new anti-peptic ulcer drug whose mechanism of action is different from H receptor antagonism researched and developed in recent years. It specifically acts on the parietal cells of the gastric mucosa, reducing the activity of H-K-ATPase in the parietal cells, thereby inhibiting the secretion of gastric acid caused by basal gastric acid and stimulation. Because H-K-ATPase is also called "proton pump", this class of drugs is also called "proton pump inhibitor". [0003] The omeprazole deriva...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/20A61K31/4439A61P1/04
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com