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Preparation method of ultrafine fiber medical agent type emulsion electro spinning fiber

A technology for pharmaceutical dosage forms and ultra-fine fibers, which can be applied in fiber processing, rayon manufacturing, fiber chemical characteristics, etc., can solve the problems of unfavorable controlled drug release, no phase separation, low thermal stability, etc., and achieves short cycle time and cost. low, high efficiency

Inactive Publication Date: 2006-01-25
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Chinese patent 01804242.2 uses a large number of surfactants and ultrasonic vibration, but what is obtained is only the suspension or dispersion of drug particles in the polymer solution. In the spun fibers, the drug still exists in the form of particles, which is quite A large proportion of drug particles aggregate on the surface of the fiber, which is very unfavorable for the controlled release of drugs
It is theoretically possible to use melt electrospinning technology, but it is necessary to find a combination of drug and polymer carrier that is stable and miscible in the molten state, and does not produce phase separation during the electrospinning process. Very difficult, because most water-soluble drugs have low thermal stability, and protein drugs will denature at temperatures above 37°C

Method used

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  • Preparation method of ultrafine fiber medical agent type emulsion electro spinning fiber
  • Preparation method of ultrafine fiber medical agent type emulsion electro spinning fiber
  • Preparation method of ultrafine fiber medical agent type emulsion electro spinning fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] (a) Dissolve 0.058 g of doxorubicin hydrochloride (2.46% of the polymer weight) in 1.67 ml of distilled water;

[0056] (b) Dissolve 2.3617 g of PLLA-PEG (the number average molecular weight of the copolymer is 84800 and the number average molecular weight of the PEG segment is 750) in 25 ml of chloroform to obtain a transparent and uniform solution. Then 0.1181 g of sodium lauryl sulfate was added to the solution as a surfactant. Since sodium lauryl sulfate is insoluble in chloroform, it can be uniformly dispersed in the chloroform solution of PLLA-PEG by ultrasonic vibration or mechanical stirring;

[0057] (c) Place the solution obtained in step (b) in a beaker, turn on the high-shear mixing emulsifier for pre-emulsification for 2 minutes, keep the emulsification rate at 7000 rpm, and slowly drop the aqueous solution of adriamycin hydrochloride into the solution in. After the dripping is completed, continue emulsification for 15 minutes to obtain a stable W / O emulsion. D...

Embodiment 2

[0067] (a) Dissolve 0.0401 g of doxorubicin hydrochloride (2.06% of the polymer weight) in 1.67 ml of distilled water;

[0068] (b) Dissolve 1.9474 g of PLLA-PEG (the number average molecular weight of the copolymer is 97600 and the number average molecular weight of the PEG segment is 5000) in 25 ml of chloroform to obtain a transparent and uniform solution. Then 0.0974 g of sodium lauryl sulfate was added to the solution as a surfactant. Since sodium lauryl sulfate is insoluble in chloroform, it can be uniformly dispersed in the chloroform solution of PLLA-PEG by ultrasonic vibration or mechanical stirring;

[0069] (c) Same as step (c) in Example 1, except that the emulsification rate is 6500 rpm;

[0070] (d) Electro-spinning the W / O emulsion obtained in step (c) to obtain an ultrafine fiber pharmaceutical dosage form supporting water-soluble drugs. The parameters in the electrospinning process are: a right-angle flat nozzle made of a No. 7 needle is used, the spinning flow ra...

Embodiment 3

[0072] (a) Dissolve 0.048 g of doxorubicin hydrochloride (3.33% of the polymer weight) in 1.67 ml of distilled water;

[0073] (b) Dissolve 1.1443g PLLA (viscosity average molecular weight of 153,000) and 0.0572g glycerol monostearate in 25ml chloroform;

[0074] (c) Same as step (c) in Example 1;

[0075] (d) Electro-spinning the W / O emulsion obtained in step (c) to obtain an ultrafine fiber pharmaceutical dosage form supporting water-soluble drugs. The parameters in the electrospinning process are: a right-angle flat nozzle made of a No. 7 needle is used, the spinning flow rate is 3.5ml / h, the applied voltage is 35kV, and the distance between the two poles is 18cm. The average diameter of the obtained drug-loaded fiber is 600nm, see Figure 7 .

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Abstract

The invention belongs to superfine fiber medicine agent latex electric spinning manufacture technology field. Under the existing of little surface activator, the medicine solution would be equally dispersed into the carrier macromolecule solution to form latex, taking electric spinning to the latex to gain medicine carried superfine fiber non-woven fabrics or fiber felt. The invention has advantages of simple technology, low cost of device and no need to have the same solution of medicine and carrier copolymer. It has steadily medicine releasing action.

Description

Technical field [0001] The invention belongs to the technical field of emulsion electrospinning preparation of ultrafine fiber pharmaceutical dosage forms. technical background [0002] Electrospinning is an effective method to obtain ultrafine fibers with diameters from nanometers to micrometers. It is a spinning technology invented in the 1930s. Since it is one of the few or even the only simple and feasible method to obtain long fibers with nanometer diameters, since the 1990s, with the development of nanoscience and nanotechnology and the increase in demand for nanomaterials, people have paid more and more attention to electromechanical Spinning technology has obtained a series of research results and patented technologies in terms of electrospinning mechanism, electrospinning process and equipment, and electrospinning applications. [0003] So far, people have successfully used electrospinning technology to spin ultrafine fibers of dozens of polymers, including synthet...

Claims

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Application Information

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IPC IPC(8): D01F1/10D01D5/00D01D1/00
Inventor 景遐斌徐秀玲陈学思徐效义梁奇志杨立新边新超
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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