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Hemostatic material of new type pore-borne molecular sieve and preparation method

A technology of mesoporous molecular sieves and hemostatic materials, applied in the field of mesoporous molecular sieve hemostatic materials and their preparation, to achieve the effects of cheap and easy-to-obtain raw materials, mild reaction conditions, and easy operation

Inactive Publication Date: 2006-02-01
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no domestic and foreign patent literature reports on the application of mesoporous materials in blood coagulation materials, wound treatment and trauma repair, and the combination of mesoporous materials with medical bandages and medical adhesives in different forms for trauma repair

Method used

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  • Hemostatic material of new type pore-borne molecular sieve and preparation method
  • Hemostatic material of new type pore-borne molecular sieve and preparation method
  • Hemostatic material of new type pore-borne molecular sieve and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 2.08g (10mmol) TEOS was dissolved in 10g ethanol, 0.5g water and 0.4g 0.1M HCl were added to the solution, stirred at room temperature for 1 hour, mixed evenly and then mixed with 0.9g triblock copolymer surfactant P123 (EO 20 PO 70 EO 20 ), stirred at room temperature for 1 hour and mixed with ethanol solution. Transfer the above-mentioned clear solution to a large petri dish, and remove the solution ethanol by natural volatilization (complete drying, generally takes 1 day), and a colorless, transparent and soft thick film is obtained. After the film was separated from the bottom of the petri dish, put it into a 100ml polytetrafluoroethylene bottle, add about 70ml of water, and conduct a hydrothermal treatment in an oven at 100°C for 72 hours. A white opaque thick film was obtained, separated by suction filtration, dried at room temperature and calcined at 500°C for 6 hours to remove the surfactant, and a two-dimensional hexagonal phase (p6mm structure) pure silica ...

Embodiment 2

[0039] 0.40g EO at room temperature 39 BO 47 EO 39 (B50-6600) was dissolved in 30g of 0.5mol / L HCl solution, and 2.08g of TEOS was added to the resulting clear solution. The molar ratio of each reactant was TEOS / EO 39 BO 47 EO 39 / HCl / H 2 O=1:0.0074:6:166. After the reactant was stirred at room temperature for one day, it was hydrothermally heated at 100° C. for one day. The resulting white precipitate was filtered, washed three times with deionized water, and dried at room temperature. Baking at 550° C. in an air atmosphere for 6 hours to remove the template agent, the heating rate was controlled at 2° C. / min, and finally a three-dimensional cubic phase (Im3m structure) pure silica mesoporous molecular sieve powder material was obtained. Its coagulation effect is good.

Embodiment 3

[0041] 4.0g nonionic surfactant EO 20 PO 70 EO 20 (P123), 1.4g calcium nitrate (Ca(NO 3 ) 4 4H 2 O), 6.7g tetraethyl orthosilicate (TEOS) was dissolved in 60g ethanol, then added 1.0g 0.5M hydrochloric acid solution, stirred at room temperature for 24h, poured into a petri dish, and aged for about 72h to make the hydrolysis-polycondensation reaction fully Proceed to form a gel and place the gel in a desiccator. The gel block obtained after drying is calcined at 700° C. for 5 hours in a muffle furnace to obtain a two-dimensional hexagonal phase (p6mm structure) silicon oxide mesoporous molecular sieve material containing calcium oxide. Its coagulation effect is good.

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Abstract

A styptic mesoporous molecular sieve material is synthesized by sol-gel method where the self-assembling property and template action of surfactant are used. Its advantages are regulatable and uniform nano-pores, high specific surface area and pore volume, and regulatable component chosen from SiO2, calcium oxide, aluminium oxide, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to a class of mesoporous molecular sieve hemostatic materials with different mesoscopic structures, compositions, shapes, etc. and a preparation method thereof. technical background [0002] In 1992, researchers from Mobil Corporation successfully synthesized the world's first M41S series silica (aluminum)-based ordered mesoporous molecular sieve material with uniform and adjustable pore size and large specific surface area by using the self-assembly and template function of surfactants. Mesoporous silica materials represented by MCM-41 and SBA-15 have aroused widespread interest, and research on mesoporous materials continues to deepen and expand. Because mesoporous materials have high surface area and pore volume, uniform and adjustable pore size, highly ordered and easily adjustable mesoporous structure (such as pore size, dimension, channel connection mod...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/42C01B37/00
Inventor 余承忠严晓霞赵东元
Owner FUDAN UNIV
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