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Transfer factor powder spray and preparation process thereof

A technology of transfer factor and powder spray, which is applied in the field of medicine, can solve the problems of non-ideal route of administration, low bioavailability, slow onset of action, etc., and achieve the effect of facilitating drug absorption, good compliance, and fast onset of action

Inactive Publication Date: 2006-02-22
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest disadvantage is slow onset of action and low bioavailability, which is not an ideal route of administration for biochemical drugs that are relatively expensive and easily degraded by enzymes in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take by weight percentage: transfer factor 1%, hyaluronic acid 3%, lactose 96%, add water and mix evenly to make the solid content 7 g / L, adopt spray drying method, drying conditions: inlet temperature is 120 ℃, compressed air flow rate 400 liters / hour, the cyclone size is 28 cubic meters / hour, and the constant flow pump speed is 1.5 milliliters / minute, make dry powder, pack into dry powder administration device, make transfer factor powder aerosol.

Embodiment 2

[0039] Take by weight percentage: transfer factor 0.5%, hydroxypropyl cellulose 2%, mannitol 97.5%, add water and mix evenly, make solid content be 12 g / liter, adopt spray drying method, drying condition: inlet temperature is 140 ℃, The compressed air flow rate is 350 liters / hour, the size of the cyclone is 24.5 cubic meters / hour, and the speed of the constant flow pump is 1.25 milliliters / minute. It is made into a dry powder and packed into a dry powder drug delivery device to make a transfer factor powder aerosol.

Embodiment 3

[0041] Get by weight percentage: transfer factor 50%, chitosan 20% (need to dissolve with 2% acetic acid solution in an appropriate amount), cyclodextrin 30%, add water and mix, make the solid content be 5 grams per liter, use spray Drying method, drying conditions: the inlet temperature is 110°C, the compressed air flow rate is 700 liters / hour, the size of the cyclone is 33.25 cubic meters / hour, the speed of the constant flow pump is 3.75 ml / minute, make dry powder, and put it into a dry powder drug delivery device In the process, transfer factor powder spray was made.

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Abstract

The invention discloses a transfer factor powder spray and preparation process, which comprises the following constituents (by weight percent): transfer factor 0.5-50%, adhesive material 0-30%, filling agent 6.8-97.5%, phosphatides surface active agent 0-60%, amino acid 0-50% and absorption promoting agent 0-10%.

Description

Technical field: [0001] The invention belongs to the technical field of medicine. The invention relates to a powder mist and a preparation method thereof, in particular to a powder mist administered through oral mucosa and a preparation method thereof. Background technique: [0002] Transfer factor, first discovered by Lawrence in 1949 from the transmission of tuberculin through human blood, can transfer delayed-type hypersensitivity or other cell-mediated immune responses between individuals or even between species, and transfer the donor's cells Immunity is passed to the recipient's normal lymphocytes, which acquire the immunity of the donor cells. Transfer factor is a complex composed of polypeptides and polynucleotides. It is generally believed that the porcine spleen transfer factor solution contains polypeptides, free amino acids, nucleotides, various bases, nucleic acid degradation products, prostaglandins and other substances. Its protein reaction is negative, biur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/02A61K9/12A61P37/02
Inventor 蒋建兰赵广荣郭晓静元英进葛志强
Owner TIANJIN UNIV
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