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Oral disintegrating notoginseng total saponin tablet and its prepn process

A technology for total saponins of Panax notoginseng and oral disintegrating tablets is applied in the field of traditional Chinese medicine pharmaceutical preparations, which can solve the problems of complicated administration routes of injections, inconvenient medication, poor taste and the like, and achieve good social and economic benefits, convenient packaging and good taste. Effect

Inactive Publication Date: 2006-03-01
郑州三创释药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Panax notoginseng saponins preparations include tablets, capsules, granules, injections, etc., which are made of Panax notoginseng saponins plus an appropriate amount of excipients, and its curative effect is definite; but these preparations all have obvious shortcomings
The route of administration of injections is cumbersome, and patients must be injected in the hospital, and the injections are painful; tablets, capsules, etc. are inconvenient for patients with swallowing dysfunction, and it takes a long time for the drugs to dissolve from the preparations. The effect is slow; the granules need a lot of water and the taste is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The orally disintegrating tablets of Panax notoginseng saponins of the present invention are composed of raw materials of Panax notoginseng saponins, disintegrants, lubricants, glidants, flavoring agents, and fillers according to the following weight percentages:

[0026] Panax notoginseng saponins: 16.67%; disintegrant: croscarmellose sodium 8%; lubricant: magnesium stearate 1%; glidant: micronized silica gel 1%; flavoring agent: aspartame 3%; filler: mannitol 69.53%; essence 0.8%.

[0027] The preparation method of the present invention is carried out according to the following steps:

[0028] (1) Dry the raw material powder of Panax notoginseng saponins, sieve, mix with dry disintegrants, fillers, glidants, and flavoring agents according to the stated ratio, then add lubricant, mix well, and obtain tablet compression mold substance;

[0029] (2) Put the tablet molding material into the feeder of the tablet pressing equipment, and press it into tablets.

Embodiment 2

[0031] The orally disintegrating tablets of Panax notoginseng saponins of the present invention are composed of raw materials of Panax notoginseng saponins, disintegrants, lubricants, glidants, flavoring agents, and fillers according to the following weight percentages:

[0032] Panax notoginseng saponins: 30.37%; disintegrant: croscarmellose sodium 4%, sodium carboxymethyl starch 4%; lubricant: talcum powder 0.3%; glidant: micronized silica gel 0.7%; flavoring Agent: maltitol 2%; filler: mannitol 32%, lactose 26.5%; essence 0.13%.

[0033] The preparation method of the present invention is carried out according to the following steps:

[0034] (1) Mix the total saponins of Panax notoginseng, part of the filler and part of the disintegrating agent, use povidone as the binder, and ethanol or a mixture of ethanol and water as the wetting agent to prepare wet granules of the active ingredient;

[0035] (2) After the wet granules are dried, the remaining raw materials are added a...

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PUM

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Abstract

The oral disintegrating notoginseng total saponin tablet consists of notoginseng total saponin 5-40 wt%, disintegrating agent 2-30 wt%, lubricant 0.2-5 wt%, flow assistant 0.1-2.5 wt%, and corrective 0.1-5 wt%, except stuffing. The oral disintegrating notoginseng total saponin tablet is easy to be taken, especially by those with dysphagia and in some no-water condition. It may be disintegrated in oral cavity without needing chewing and absorbed via mucous membrane in oral cavity to take effect or swallowed to stomach for fast effect in high bioavailability and short medicine leaching out time.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to an orally disintegrating tablet of Panax notoginseng saponins, and also relates to a preparation method of the preparation. Background technique [0002] Panax notoginseng saponins are important drugs for the treatment of cardiovascular and cerebrovascular diseases. Pharmacological studies have shown that Panax notoginseng saponins have hemostasis, blood stasis, and antithrombotic effects on the blood system; they have protective effects on myocardial and brain tissue, and can expand blood vessels, lower blood pressure, and lower blood lipids. In addition, they also have sedative and analgesic effects. Panax notoginseng saponins preparations include tablets, capsules, granules, injections, etc., which are made of Panax notoginseng saponins plus appropriate amount of excipients, and have definite curative effects; but these preparations all have obvious deficiencies. ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/20A61P9/00
Inventor 周毅生陈小保李竞
Owner 郑州三创释药技术有限公司