Docetaxel freeze-dried powder-injection, and its prepn. method

A freeze-dried powder injection and docetaxel technology, which is applied in the field of drug preparation, can solve the problems of reducing the content of the main drug docetaxel, poor quality stability of injections, easy oxidation and hydrolysis, etc., to facilitate industrial production and product Good stability, increase the effect of quality stability
CN1868459AInactive Publication Date: 2006-11-29YUNNAN YUYAO BIOPHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YUNNAN YUYAO BIOPHARM CO LTD
Publication Date
2006-11-29
Estimated Expiration
Not applicable · inactive patent
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Abstract

A freeze-dried powder injection of Duoxitasai is proportionally prepared from Duoxitasai and the auxiliary chosen from alcohol, tween-80, glycerin, Na2EDTA, propanediol, polyethanediol 400, mannitol and sodium pyrosulfite. Its preparing process is also disclosed.
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Description

technical field

[0001] The invention relates to the technical field of medicine preparation, in particular to docetaxel freeze-dried powder injection and a preparation method thereof. technical background

[0002] Docetaxel, also known as docetaxel, is a paclitaxel antineoplastic drug obtained by semi-synthesis with 10-DAB as the mother nucleus skeleton. For the treatment of ovarian cancer, breast cancer and non-small cell lung cancer that are refractory to conventional chemotherapy.

[0003] Docetaxel is currently available in the form of injection. This product is a yellow to yellow-brown transparent viscous liquid, which is a liquid obtained by dissolving anhydrous docetaxel in Tween-80. It is equipped with a special solvent of 13% (w / w) ethanol aqueous solution for injection. For clinical use, first suck out all the solvent for injection, inject it into the corresponding docetaxel solution bottle, and mix it manually by inversion for at least 40 seconds, then leave the...

Claims

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