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A sodium alginate microsphere vascular embolizing agent containing water soluble drug, its preparation and application

A technology for a water-soluble drug and a vascular embolizing agent, which is applied in the fields of vascular embolizing agent and its preparation and application, can solve the problem of high recurrence rate, and achieve the effects of reducing toxic side effects, improving curative effect and strong hydration power

Active Publication Date: 2006-12-20
BEIJING SHENGYIYAO SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the application of chemoembolization at home and abroad can be used clinically in the treatment of liver cancer, kidney cancer, pelvic cavity tumors and head and neck tumors, and has received good curative effect, but the recurrence rate after embolization is high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of sodium alginate microspheres containing arsenic trioxide, human serum albumin and chitosan

[0051] 1. Preparations before packing:

[0052] ① Handling of glassware:

[0053] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0054] ② Preparation of the mixed solution of arsenic trioxide and human serum albumin:

[0055] Weigh 700 mg of commercially available arsenic trioxide, place it in the above-mentioned glass vessel, add water for injection dropwise to dissolve; dissolve 1000 mg of human serum albumin with water for injection to obtain a mixed solution of arsenic trioxide and human serum albumin;

[0056] ③ Preparation of sodium alginate solution:

[0057] Weigh 1 gram of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0...

Embodiment 2

[0068] Preparation of sodium alginate microspheres containing doxorubicin, human serum albumin and sodium hyaluronate

[0069] 1. Preparations before packing:

[0070] ① Handling of glassware:

[0071] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0072] ② Preparation of mixed solution of doxorubicin and human serum albumin:

[0073] Weigh 700 mg of commercially available doxorubicin, place it in the above-mentioned glass vessel, add dropwise water for injection to dissolve; dissolve 10 grams of human serum albumin with water for injection, and obtain a mixed solution of doxorubicin and human serum albumin;

[0074] ③ Preparation of sodium alginate solution:

[0075] Weigh 10 grams of commercially available sodium alginate, place it in a glass container, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0076] ④...

Embodiment 3

[0086] Preparation of Sodium Alginate Microspheres Containing Daunorubicin, Human Serum Albumin and Chitosan

[0087] 1. Preparations before packing:

[0088] ① Handling of glassware:

[0089] Dry the cleaned glassware in a high-temperature oven at 300 degrees Celsius for 3 hours (sterilize and remove heat source);

[0090] ② Preparation of the mixed solution of daunorubicin and human serum albumin:

[0091] Take by weighing 700 mg of commercially available daunorubicin, place in the above-mentioned glass vessel, add dropwise water for injection to dissolve; dissolve 1000 mg of human serum albumin with water for injection to obtain a mixed solution of daunorubicin and human serum albumin;

[0092] ③ Preparation of sodium alginate solution:

[0093] Weigh 1 gram of commercially available sodium alginate, place it in a glass vessel, and add physiological saline while stirring until the sodium alginate is completely dissolved to obtain a sodium alginate solution;

[0094] ④ P...

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Abstract

The invention relates to a sodium alginate micro ball vessel suppository which contains soluble medicine, and relative preparation and application, wherein said agent can be divided into two kinds as wet ball and dry ball made from degradable biological material; said carrier comprises sodium alginate, blood serum albumin, chitose, or transparent sodium solution, via the static to be solidified with calcium ion, to be made into the micro ball at 20 mum-1000 mum. The inventive material has high mechanical strength, biological compatibility, biological degradability and stability. The invention can be used to cure the vessel suppository of variable cancers.

Description

technical field [0001] The present invention relates to vascular embolic agents and their preparation and application, in particular to degradable biomaterial microspheres containing water-soluble drugs. Sugar or sodium hyaluronate solution is solidified with calcium ion solution under the action of static electricity, and then made into microspheres of 20 μm--1000 μm under the strong solidification of acetone, which can be divided into microspheres of different sizes according to needs. It can be stored in wet bulbs, and can also be stored in dry bulbs by freezing technology. The microspheres made of water-soluble drugs have not been reported in China at present by using wet bulbs to preserve them. The raw material used in the invention has good biocompatibility and biodegradability, and is a safe and effective new dosage form of embolization plus targeted chemotherapy through animal experiments and clinical observations. For the treatment of solid tumors in humans or anima...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/48A61K47/36A61K31/7076A61K31/475A61K31/675A61P35/00A61K47/61A61K47/62
Inventor 李小平李新建崔恒魏丽惠冯捷郎景和向阳雷呈志洪宏
Owner BEIJING SHENGYIYAO SCI & TECH DEV
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