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Sustained-releasing oral mucosa medicinal film

A slow-release patch and oral mucosa technology, which is applied in the direction of drug combination, sheet delivery, and pharmaceutical formulations, can solve the problems of patch falling off, short drug release time, and loss of therapeutic effect of oral diseases Strong, long release time, convenient application effect

Inactive Publication Date: 2006-12-27
何元
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first is that the drug release time is still too short. Only a limited part of the drug ingredients in the lozenge can penetrate into the submucosa through the contact between saliva and mucous membranes, while most of the drugs enter the stomach with the swallowing of saliva, and are basically lost. Therapeutic Effects on Oral Diseases
Second, simply increasing the dose can lead to an unacceptably strong bitter taste of antibiotics
The main reason why these examples have not been used in practice is that the patches have fallen off

Method used

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  • Sustained-releasing oral mucosa medicinal film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 The oral mucosa drug sustained-release patch adopts the following raw material components and proportions: 8.0 grams of polyvinylpyrrolidone, 8.0 grams of polyoxyethylene, 10.0 grams of microcrystalline cellulose, 1.5 grams of flavoring agent menthol, active pharmaceutical ingredients Minocycline 2.5 grams.

[0025] A flat-bottomed mold with a diameter of 5 mm is used to prepare the tablet directly. The specific preparation method is: uniformly mix the dry powder of the above-mentioned excipients and the dry powder of the active drug according to the formula ratio, and adopt the direct compression conditions of 1000 kg of pressure and 6 seconds. A flat cylindrical patch is made. The thickness of the patch is 0.8-1.2 mm, and the weight of the patch is 25.0-32.0 mg.

[0026] A piece of the oral mucosa drug sustained-release patch sample was taken for a dissolution test. The diameter of the sample was 5.0 mm, the thickness was 1.2 mm, and the weight was 30 mg. ...

Embodiment 2

[0031] Example 2 The oral mucosa drug sustained-release patch adopts the following raw material components and proportions: 12.0 grams of hydroxyethyl cellulose, 5.5 grams of modified starch, 7.0 grams of microcrystalline cellulose, 0.5 grams of flavoring agent grape essence, effective drug Chlorhexidine 4.0 g.

[0032] A flat-bottomed mold with a diameter of 5 mm was used to prepare the tablet directly. The specific preparation method was the same as in Example 1. A patch sample was taken for an oral disintegration test. The patch had a thickness of 0.8 mm and a weight of 30 mg. The patch is attached to the surface of the gums of the human body, and the patch adheres to the surface of the gums within 3 minutes, completely sticks to the gums after 10 minutes, and completely erodes and disappears after 2 hours.

Embodiment 3

[0033] Example 3 The oral mucosa drug sustained-release patch adopts the following raw material components and proportions: 2.0 grams of methyl vinyl ether-maleic anhydride copolymer, 2.0 grams of polyoxyethylene, 2.0 grams of sodium hydroxymethylcellulose, natural 12.0 grams of starch, 2.0 grams of flavoring agent menthol, and 0.5 grams of effective drug doxycycline.

[0034] A flat-bottomed mold with a diameter of 5 mm was used to prepare the tablet directly. The specific preparation method was the same as in Example 1. A patch sample was taken for an oral disintegration test. The patch had a thickness of 0.8 mm and a weight of 25 mg. The patch is attached to the surface of the gums of the human body. The patch adheres to the surface of the gums within 3 minutes, completely sticks to the gums after 10 minutes, and completely erodes and disappears after 2.5 hours.

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Abstract

Disclosed is a medicinal preparation for treating oral mucosa diseases comprising active medicinal constituents and auxiliary materials, which can be in the form of paster obtained through sheet pressing or thin films obtained through liquid phase film forming, the effective medicinal constituents can be antibiotic medicaments including Minocycline, hibitane, fortimicin, achromycin or metronidazole, the auxiliary materials include binding agent, disintegrating agent and flavoring agent.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for treating oral mucosal diseases, in particular to a slow-release patch for oral mucosal medicines for treating oral periodontal diseases. Background technique [0002] Periodontal diseases such as periodontitis are relatively common oral diseases. Even in developed countries, the incidence rate of adults can reach more than 50%. It is more serious in areas with poor medical conditions, and can be as high as 90%. There are many causes of periodontal disease, and its formation mechanism is complex. Periodontal diseases such as periodontitis are generally believed to be infectious diseases caused by specific forms of bacteria in dental plaque. Plaque microorganisms and their products act on the gums for a long time, causing the body's immune response, first leading to an inflammatory response of the gums. When suffering from gingivitis, the inflammation is limited to the gingival epit...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/32A61K47/34A61K45/00A61K31/155A61K31/4164A61K31/665A61P1/02A61K47/10
Inventor 何元
Owner 何元
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