Method for producing human thymosin alphal utilizing transgenic tomato

A technology of thymosin and human thymus, which is applied in the fields of biochemical equipment and methods, genetic engineering, plant genetic improvement, etc., can solve the problems of antigenicity of impurities, difficult to be widely used, and small clinical efficacy, so as to save transportation, The effect of avoiding cross infection and reducing production costs
CN1891824AInactive Publication Date: 2007-01-10THE INST OF BIOTECHNOLOGY OF THE CHINESE ACAD OF AGRI SCI +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
THE INST OF BIOTECHNOLOGY OF THE CHINESE ACAD OF AGRI SCI
Publication Date
2007-01-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method to produce human thymosin alpha 1 that uses transgene tomato as bio-reactor. It optimizes the nucleotide sequence of human thymosin alpha 1 according to plant preference codon. Compounding the gene and making it connect end to end to form tetrad, then, the plant expression transforming tomato expressed by thymosin alpha 1 cascading gene that is driven by cauliflower 35s promoter would be constructed. The thymosin alpha 1 would have important effect in vivo that could promote T cell function and the producing of special antibody and cell element. It could cure autoimmune diseases like lupus erythematosus, chronicity hepatitis B, etc. It could be also used as assistant medicine for curing cancer and tumor. The fruit containing thymosin alpha 1 could enhance human body immunity.
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Description

technical field

[0001] The invention relates to a method for producing human thymosin α1 by transgenic tomato. Background technique

[0002] Thymosin α1 (Thymosin-α1, Tα1) is a polypeptide with strong immune activity secreted by the thymus, the central immune organ of the human body. It consists of 28 amino acid residues, is rich in acidic amino acids, and is heat-stable at 80°C. The PI value of Tα1 is 4.2, and the theoretical molecular weight is 3.108kDa. It has no high-level spatial structure, no disulfide bond and glycosylation modification, and the only modification is N-terminal acetylation. Tα1 plays an important role in the body. It can promote the function of T cells, promote the production of specific antibodies and cytokines, and strengthen the immune system. Clinically, purified Tα1 can treat immunodeficiency diseases, such as lupus erythematosus, chronic hepatitis B, hepatitis C, etc. It can also be used as an auxiliary drug for the treatment of tumors and cance...

Claims

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