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Grape extract containing medicine composition and its preparation and use

A technology of grape skin extract and composition, applied in pharmaceutical composition, pharmaceutical composition of grape seed extract, containing grape skin extract field, can solve the problem of narrow nutritional composition, high price, beauty, anti-aging, anti-aging Tumor, prevention of arteriosclerosis and treatment of heart disease have little effect, to achieve the effect of preventing arteries

Inactive Publication Date: 2007-03-14
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Many countries in the world have done clinical trials for many years and developed many health care products. Now there are grape extract health care drugs such as American "Pulean" and Canadian "Diplosu" in the Chinese market, as well as natural sheep Placenta and other types of nutritional health products, but these products are not only expensive, but also have a narrow range of nutritional components, and have little effect on beauty, anti-aging, anti-tumor, prevention of arteriosclerosis and treatment of heart disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] The tablet preparation of embodiment 1 medicine of the present invention

[0087] 1. Main ingredients

[0088] Grape seed extract (99% proanthocyanidin content) 200 parts

[0089] Grape skin extract (polyphenol content 30%) 100 parts

[0090] Total saponins of ginseng stems and leaves (content 90%) 25 parts

[0091] Second, accessories

[0092] β-cyclodextrin 100 parts

[0093] Mannitol 100 parts

[0094] Starch 150 parts

[0095] Low-substituted hydroxypropyl cellulose 50 parts

[0096] Hypromellose 2.5% qs

[0097] Macrogol 6000 2.5% appropriate amount

[0098] EtOH:H 2 O=1:1 appropriate amount

[0099] Micropowder silica gel 40 parts

[0100] Sodium carboxymethyl starch 40 parts

[0101] Cross-linked polyvinylpyrrolidone 10 parts

[0102] Magnesium stearate 10 parts

[0103] Croscarmellose sodium 10 parts

[0104] Carboxymethylcellulose calcium 10 parts

[0105] Xylitol 100 parts

[0106] Microcrystalline cellulose 80 parts

[0107] Peach essence 5 ...

Embodiment 2

[0113] The tablet preparation of embodiment 2 medicines of the present invention

[0114] 1. Main ingredients

[0115] Grape seed extract (proanthocyanidin content 70%) 50 parts

[0116] Grape skin extract (polyphenol content 80%) 300 parts

[0117] Total saponins from ginseng stems and leaves (content 60%) 1 part

[0118] Second, accessories

[0119] β-cyclodextrin 200 parts

[0120] Mannitol 200 parts

[0121] Starch 300 parts

[0122] Low-substituted hydroxypropyl cellulose 100 parts

[0123] Hypromellose 2.5% qs

[0124] Macrogol 6000 2.5% appropriate amount

[0125] EtOH:H 2 O=1:1 appropriate amount

[0126] Micropowder silica gel 80 parts

[0127] Sodium carboxymethyl starch 80 parts

[0128] The production method is as follows:

[0129] 1. Accurately weigh the main and auxiliary materials according to the specified ratio, and pass through 90 and 100 mesh sieves respectively for later use;

[0130] 2. Fully mix grape seed extract, grape skin extract and micro...

Embodiment 3

[0134] The tablet preparation of embodiment 3 medicines of the present invention

[0135] 1. Main ingredients

[0136] Grape seed extract (proanthocyanidin content 85%) 400 parts

[0137] Grape skin extract (polyphenol content 70%) 1 part

[0138] Total saponins of ginseng stems and leaves (content 80%) 100 parts

[0139] in:

[0140] Grape seed extract and grape skin extract were purchased from Shanghai Kangjiu Chemical Co., Ltd.; total saponins from ginseng stems and leaves were purchased from Jilin Hongjiu Biotechnology Co., Ltd.

[0141] Second, accessories

[0142] Hypromellose 2.5% qs

[0143] Macrogol 6000 2.5% appropriate amount

[0144] EtOH:H 2 O=1:1 appropriate amount

[0145] Cross-linked polyvinylpyrrolidone 20 parts

[0146] Magnesium stearate 20 parts

[0147] Croscarmellose sodium 20 parts

[0148] Carboxymethylcellulose calcium 20 parts

[0149] Xylitol 200 parts

[0150] Microcrystalline cellulose 150 parts

[0151] Peach essence 20 parts

[01...

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PUM

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Abstract

The invention discloses a drugs combination containing extraction of grape, its principal agents are grape seed extract (the content of procyanidin is 70 -99%) 50-400 portions, grape bark extract (polyphenol content 50 -80%) 1-300 portions, total saponin(content 60 -90%) of the ginseng stem and leaf is 1-100 portions and some other excipients. Its preparation method is to weigh the main and auxiliary materials pro rate, sieve through mesh sieve 90-150 with screen mesh, then fully mix them with part of the excipients, sieve through mesh sieve with 20-50 screen mesh, then add saponin of the ginseng stem and leaf with other excipients, mix them evenly, then add the commixture adhesive, mix uniformly and dry, after they are made into granules they can be made into kinds of conventional dosage forms.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition containing grape skin extract and grape seed extract, a preparation method and its application in beauty treatment, anti-aging, anti-tumor, prevention of arteriosclerosis and treatment of heart disease, etc. The application of aspect belongs to the field of traditional Chinese medicine. Background technique [0002] Grapes are called the "King of Fruits" and are deciduous vines of the genus Vitis vinifera. Most of the grape producing areas are located north of the Tropic of Cancer and south of 50 degrees north latitude. 90% of the world's grape production is used to brew wine. Wine is the second largest alcoholic beverage after beer. The world's annual average wine production reaches more than 50 million tons, and it is increasing year by year. The steady development of the wine industry is mainly attributed to the rich nutrition and health ca...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P9/10A61P39/06A61P17/16
Inventor 郭爱华
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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