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Composite stand materials of polylactic acid base/nano-hydroxy-apatite and its production

A nano-hydroxyapatite, polylactic acid-based technology, used in medical science, prostheses, bone implants, etc., can solve the problems of simple chemical structure and uneven dispersion of nano-hydroxyapatite, and achieve good compatibility. The effect of stability and uniform dispersion

Inactive Publication Date: 2007-04-04
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, these composite materials still have shortcomings, such as the chemical structure of the polylactic acid material itself is simple; and nano-hydroxyapatite is not uniformly dispersed in polylactic acid.

Method used

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  • Composite stand materials of polylactic acid base/nano-hydroxy-apatite and its production
  • Composite stand materials of polylactic acid base/nano-hydroxy-apatite and its production
  • Composite stand materials of polylactic acid base/nano-hydroxy-apatite and its production

Examples

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Effect test

Embodiment 1

[0035]Example 1. First, calcium nitrate and diammonium hydrogen phosphate were weighed according to Ca / P=1.67 and each prepared into aqueous solutions. The aqueous solution of diammonium hydrogen phosphate was dropped into the aqueous solution of calcium nitrate, and the temperature was controlled at room temperature and the reaction system PH=10-11, make it chemically react to produce colloidal HA precipitate, after the reaction is completed, add PEG2000 aqueous solution with a weight concentration of 0.1% as a surfactant. The nano-hydroxyapatite is obtained by aging at room temperature for 10-20 hours, repeatedly filtering, washing, and then drying. Put the prepared xylene solution of nano-hydroxyapatite into a device with condensation, reflux, nitrogen protection, and stirring, and then add dropwise the xylene solution of lactide, lactide and nano-hydroxyphosphorus The mass ratio of graystone is 1:1, and the reaction is carried out at 120°C for 16 hours. After the reaction, the...

Embodiment 2

[0036] Example 2. The synthesis and modification of nano-hydroxyapatite are the same as in Example 1. Lactide and glycolide were reacted with stannous octoate as a catalyst at 140°C for 10 hours at a molar ratio of 85:15 to obtain a polylactic acid-glycolic acid copolymer (PLGA) with a molecular weight of 130,000. The above-mentioned PLGA and the modified nano-hydroxyapatite are weighed at a weight ratio of 100:5, NaCl is 1% of the weight of PLGA, and dissolved in a dioxane-water solution system with a volume ratio of 87 / 13. PLGA The PLGA(85 / 15) / HA composite porous tissue engineering scaffold was obtained by initializing at -10°C for 2h and then curing for 10min, freeze-drying for 72h, and annealing at 30°C for 6h. The concentration was 9%.

Embodiment 3

[0037] Example 3. The synthesis and modification of nano-hydroxyapatite and the synthesis of PLGA (75 / 25) are the same as in Example 1. The above-mentioned PLGA (75 / 25) and modified nano-hydroxyapatite were weighed at a weight ratio of 100:5, and dissolved in a dioxane-water solution system with a volume ratio of 87 / 13. The concentration of PLGA was 9%, using a step-by-step initialization method to first roughen at 5°C for 1 hour, then at 0°C for 2 hours, solidify for 30 minutes, freeze-dry for 72 hours, and anneal at 30°C for 6 hours to obtain a PLGA / HA composite porous scaffold Engineering stent, the SEM picture is shown in Figure 5(a).

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Abstract

A porous scaffold material for tissue engineering is the composition of a polylactic acid type polymer, such as poly-L-lactic acid (PLLA), poly-D, L-lactic acid (PDLLA) and poly-L-lactic acid / hydroxyacetic acid copolymer (PLGA), and a modified nano-class hydroxyapatite (NHA). It is prepared by the thermal phase separation technique.

Description

Technical field [0001] The invention belongs to the technical field of polymer materials and the technical field of biomedical engineering, and specifically relates to a polylactic acid-based / nano-hydroxyapatite composite scaffold material and a preparation method thereof. technical background [0002] In plastic surgery, bone repair and regeneration is a common and complex clinical problem. Millions of people worldwide suffer from orthopedic diseases due to trauma every year, and many people die due to lack of ideal substitute materials. The current bone graft materials mainly include autologous bone, allogeneic bone, specially processed xenogeneic bone and human bone synthetic bone materials. However, the source of autologous bone is limited and a second operation is required. Complications after transplantation can reach 8% and may cause other health problems. Seeking an ideal bone tissue replacement material is the key to solving orthopedic diseases. Therefore, the constructi...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/46A61F2/28
Inventor 任杰黄艳霞陈楚任天斌
Owner TONGJI UNIV
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