Agent for preventing/amelioration life style-related diseases containing turmeric essential oil component

A technology of life habits and improving agents, which is applied in the direction of medical preparations containing active ingredients, active ingredients of ketones, active ingredients of hydroxyl compounds, etc., can solve problems such as reducing visceral fat and lowering blood sugar levels, and achieve reducing visceral fat and inhibiting Effect of rise in blood sugar level

Inactive Publication Date: 2007-05-02
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not yet known that the essential oil components derived from turmeric (Curcuma longa L.), especially ar-curcumone, α-curcumone, and β-curcumone of bisabolane-type sesquiterpenoids, have the effect of lowering blood sugar levels and suppressing blood sugar levels. Elevation effect, visceral fat reduction effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Soak 700 g of turmeric powder (Kaneka Sun Spice Co., Ltd.) in 3.5 L of n-hexane, place it in a dark place at room temperature for 3 days, and then filter to obtain a primary extract. The filtered residue was immersed in 3.5 L of n-hexane, and after being placed in a dark place at room temperature for 1 day, it was filtered to obtain 2 extracts. The primary extract and the secondary extract were mixed and concentrated under reduced pressure to obtain 50.4 g of a hexane extract of turmeric.

[0037] As a result of silica gel thin-layer chromatography (TLC), it was confirmed that the hexane extract of turmeric contains essential oil components, but does not contain curcuminoids. Also, plates for TLC use silica gel 60F 254 (Merck), and a developing solvent was carried out using chloroform:methanol=9:1 (v / v).

Embodiment 2

[0039] Using KK-A as a type 2 diabetes model animal y In mice, the effect of the curcuma hexane extract prepared in Example 1 on suppressing blood sugar rise was evaluated.

[0040] KK-A y Mice (female, 6 weeks old) were divided into 2 groups (5 mice each), serving as a control group and a hexane extract-administered group. A refined powder feed (Oriental Yeast Industry Co., Ltd.) was given to the control group, and a refined powder feed containing 0.5% by weight of the curcuma hexane extract prepared in Example 1 was given to the hexane extract administration group. In addition, the composition of powder refined feed is: 20% by weight of casein, 49.948% by weight of cornstarch, 10% by weight of sucrose, 10% by weight of soybean oil, 5% by weight of cellulose powder, 3.5% by weight of AIN-93 mineral mixture, 3.5% by weight of AIN- 1% by weight of 93 vitamin mixture, 0.25% by weight of choline bitartrate, 0.002% by weight of t-butyl hydroquinone, and 0.3% by weight of L-cysti...

Embodiment 3

[0045] The oleoresin of turmeric (Maruzen Pharmaceutical Co., Ltd.) 30g was carried out to silica gel column chromatography, eluted with 10 volume % ethyl acetate / n-hexane, and the eluate was concentrated and dried to obtain 13.5 g of sesquiterpene fraction of turmeric.

[0046] As a result of high performance liquid chromatography (HPLC), it was confirmed that bisabolane-type sesquiterpenoids such as ar-curcumone, α-curcumone, and β-curcumone were contained in the sesquiterpene fraction of turmeric, but did not contain Curcuminoids. In addition, HPLC uses TSK gel ODS-80Ts, 4.6×75mm column (Tosoh Co., Ltd.) at 30°C, and uses acetonitrile (A) and distilled water (B) as the mobile phase. Afterwards, 15-30 minutes was set as the gradient condition of 70% A, and the flow rate was 0.7ml / min. The injection volume was 20 μl, and the detection wavelength was 254 nm.

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PUM

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Abstract

The present invention has its object to provide an agent for preventing and / or ameliorating life style-related diseases which contains, as an active ingredient, a substance derived from a safe food material having a long history of being eaten as a food and which is capable of being utilized as functional foods such as health foods or functional health foods (specific health foods, functional nutritive foods). The agent for preventing and / or ameliorating life style-related diseases according to the invention contains, as an active ingredient, at least one compound selected from the group consisting of ar-turmerone, +--turmerone, -turmerone, curlone, bisacumol and -sesquiphellandrene, or at least one compound selected from among the bisabolane type sesquiterpenoids derived from Curcuma longa L., and therefore is useful for preventing and / or ameliorating diabetes, visceral fat obesity, metabolic syndrome and obesity, among others.

Description

technical field [0001] The present invention relates to an agent for preventing and / or improving lifestyle-related diseases, which is characterized by containing an essential oil component derived from a plant material of the genus Curcuma as an active ingredient, and a functional food containing the same. Background technique [0002] Lifestyle-related diseases caused by exacerbation of lifestyle-related diseases such as overnutrition or lack of exercise are becoming a huge social problem. Examples of the lifestyle-related diseases mentioned here include obesity, diabetes, hyperlipidemia, hypertension, and the like. There are also multiple combinations of these conditions, also known as metabolic syndrome, obesity, syndrome X, death quartet, insulin resistance syndrome, visceral fat syndrome, etc. The onset basis of metabolic syndrome is considered to be insulin resistance, and the further upstream cause thereof is considered to be accumulation of visceral fat. Therefore,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A23L1/30A61K31/045A61K36/9066A61P3/00A61P3/04A61P3/06A61P3/10A61P9/12
CPCA61K36/9066A61K31/045A61K31/12A23L1/3002A23L33/105A61P3/00A61P3/04A61P3/06A61P3/10A61P9/12A61P43/00
Inventor 前辰正西山陶三岸田秀之高柿了士山本正次
Owner KANEKA CORP
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