Oral antimicrobial pharmaceutical compositions
A technology of composition and medicine, applied in the field of pharmaceutical composition of rifamycin SV
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Embodiment 1
[0065] 200 g of rifamycin SV was mixed with 5 g of stearic acid, 7 g of carnauba wax, 8 g of sodium dioctyl sulphosuccinate, 100 g of lactose and 10 g of sodium edetate, and mixed with 25 g of low viscosity polyethylene A solution of pyrrolidone in 0.2 liters of purified water forms granules. When the granulation had been dried, it was mixed with 100 g sodium carboxymethylcellulose, 25 g silicon dioxide, 5 g glycerol palmitostearate and 10 mg talc before being compressed to a unit weight of 495 mg per tablet. The cores thus obtained are then film-coated with a hydroalcoholic dispersion of acrylic and methacrylate esters, titanium dioxide, talc and triethyl citrate, which endow the product with resistance to disintegration in a strongly acidic environment simulating the environment of the stomach and small intestine. sex. The dissolution rate of the tablet is practically zero at a pH less than 7 and is scaled in percentage increments in intestinal buffer at pH 7.2 as follows: ...
Embodiment 2
[0070] 500 g of rifamycin SV was mixed with 10 g of stearic acid, 10 g of beeswax, 10 g of sodium lauryl sulfate, 200 g of mannitol and 10 g of sodium edetate and granulated in a solution containing 50 g of hydroxypropylcellulose in 0.5 liter of water . When the granules have been dried, it is mixed with 150 g sodium hydroxypropyl methylcellulose, 25 g silicon dioxide, 5 g glycerol palmitostearate and 10 mg talc before being compressed to a unit weight of 490 mg / tablet. powder mix. The cores thus obtained are then film-coated with an aqueous dispersion of acrylic acid and methacrylate esters, ferric oxide, talc and triethyl citrate, which confer disintegration of the product in an acidic environment simulating the environment of the stomach and small intestine. Solution resistance. The dissolution rate of the tablet is practically zero at a pH less than 7 and is scaled in percentage increments in intestinal buffer at pH 7.2 as follows:
[0071] Less than 30% after 1 hour re...
Embodiment 3
[0075] 2.5 kg of metronidazole was mixed with 70 g of stearic acid, 70 g of beeswax, 400 g of sucrose, 140 g of hydroxypropylmethylcellulose and 20 g of polysorbate 80, and formed into wet granules by adding purified water to an appropriate viscosity. The granules were then dried and standardized according to size before adding an additional 200 g of hydroxymethylpropylcellulose, 600 g of microcrystalline cellulose, 30 g of palm stearin and 70 g of silicon dioxide. After blending, the powder is compressed to a unit weight of 450 mg / tablet.
[0076]The cores thus obtained are then film-coated with an aqueous alcoholic dispersion of acrylic acid and methacrylate esters, ferric oxide, talc and triethyl citrate, which impart resistance to disintegration in acidic environments. The dissolution rate of the tablet is practically zero at a pH less than 7 and is scaled in percentage increments in intestinal buffer at pH 7.2 as follows:
[0077] less than 25% within the first hour of r...
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