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Pain dispelling drop pills and preparation method thereof

A technology of Shu drop pills and drop pills, which is applied in pill delivery, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of affecting the full effect of drugs, low bioavailability, and long disintegration time limit, etc. Labor protection and environmental protection, high bioavailability, and the effect of avoiding the first-pass effect of liver and intestine

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of the preparation technology of such conventional preparations, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, thus affecting the full play of the drug effect.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Pain dispelling drop pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: Take Yantuo 1000g, pulverize into coarse powder, add 95% ethanol, heat and reflux twice, add ethanol amount 8 times for the first time, 6 times for the second time, reflux for 4 hours each time, filter , The filtrate recovers ethanol and concentrates to the extract with a relative density of 1.15-1.20 (20°C), and vacuum-dries the extract to obtain the extract. Take the extract, crush it, and pass through a 100-mesh sieve. Yantuo extract by weight ratio: polyethylene glycol 6000 =1:2.5 ratio, add to the melted matrix (85°C), stir evenly, drop into the simethicone coolant (3°C), separate the dripping pills, absorb the coolant, and dry to obtain.

Embodiment 2

[0017] Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves, be Yan Tuo extract by weight ratio: the ratio of mixed matrix=1: 2 (mixed matrix is ​​polyethylene glycol 6000 : poloxamer according to 1:0.2 formula), add to the melted mixed matrix (85°C), stir evenly, drop into the simethicone coolant (3°C), separate the dropping pills, absorb the coolant , dried, that is.

Embodiment 3

[0018] Example 3: In this example, the roundness, pill weight difference, hardness, dissolution time and other indicators are investigated through the formula of Yantuo extract and different matrix, so as to determine the weight ratio of the extract to a single or mixed matrix.

[0019] Yantuo extract and different matrix formulation tests (extracts are 1 part)

[0020]

[0021] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 1-5°C; the heat preservation temperature of the medicinal material and the dripper is 80-85°C; the dripping speed is 30-50 capsules / min.

[0022] 2. The above results show that all the indicators of No. 4, 5, 6, 7, and 8 tests are good, that is, when the ratio of the extract to the matrix is ​​1:1-1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test Nos. 4, 5, 6, and 8, that is, the ratio of the extract to the matrix is ​​1:1-1:2.

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PUM

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Abstract

Disclosed is a medicinal dripping pill and process for preparation, wherein the medicament has the functions of dispersing pathogenic wind, removing dampness, promoting blood circulation and relieving pain, and can be used for treating rheumatism, articular muscle paralysis, traumatic injury and hematoma. The medicament is prepared from Chinese medicinal herb of rodgersflower rhizome through extracting and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying. The medicament also has the advantages of quicker disintegration and dissolution, higher dissolution, quick-speed medicine release, quick-speed effect, simple process for manufacturing, and low cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Santongshu dripping pill and a preparation process thereof. Background technique [0002] Pain, fever and inflammatory response are one of the clinical manifestations of many diseases. Excessive pain can cause certain damage to the body. Inflammation can cause redness, heat, pain and swelling of the inflamed part or body. These diseases seriously affect the quality of life of the patient and make the patient miserable. All countries in the world are studying the method of relieving these pains, and have produced a wide variety of chemical drugs, but they have also brought a lot of side effects and adverse reactions when relieving the pain. Santongshu preparation refined from Yantuo, a customary drug used by Lisu and Miao nationalities in Yunnan, has the functions of relieving pain, antipyretic and anti-inflammation. Clinical case obse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/20A61P29/00A61K125/00
Inventor 陈茜滕慧丽
Owner 陈茜
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