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Drop pill for treating pharyngitis and its preparation method

A technology for clearing dripping pills and pharyngitis, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve the problems of many production processes of Yanyanqing tablets, slow onset of effect of Yanyanqing tablets, and large dosage of drugs. , to achieve the effect of flexible and accurate drug dosage, avoiding first-pass effect and stable drug quality

Inactive Publication Date: 2007-07-04
YANTAI DAYANG PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as a traditional Chinese medicine tablet, due to the dosage form itself, Yanyanqing Tablet still has defects such as slow onset of action, large dosage, long treatment time, low bioavailability, and relatively unstable quality:
[0006] 2. Poor effective absorption
[0010] 6. In addition, the granulation process in the preparation process of Yanyanqing Tablets will produce relatively large dust pollution, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment
[0011] 7. The production process of Yanyanqing Tablets is many, and the production cost is relatively high, so that the cost of medication for patients is also increased, which is not conducive to improving the overall health level of the society
[0015] However, due to the dispersibility of the drop pill preparation process conditions, the prescription of Yanyanqing containing more thermally unstable and volatile active ingredients must be made into drop pill dosage forms, such as: how to avoid volatile ingredients in the process of preparing drop pills. Loss of loss, what process conditions can prevent the loss of thermally unstable components, and a series of technical problems such as how to reasonably disperse active ingredients. Therefore, so far, there is no drop pill formulation of Yanyanqing listed. , and there is no information or case of successfully applying dripping pills to the prescription of Yanyanqing

Method used

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  • Drop pill for treating pharyngitis and its preparation method
  • Drop pill for treating pharyngitis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Accurately weigh 15 g of sargassum, 0.025 g of natural borneol, and 0.05 g of menthol (sarcodon: natural borneol: menthol=300:0.5:1); add 3 times the amount of 70% ethanol for sarcodon, and heat and reflux for 1 hour , suction filtration while hot, combine the filtrates, reclaim ethanol to the extract with a relative density of 1.20 (20°C), spray dry it into a fine powder, crush the fine powder until all of it passes through a 60-mesh sieve; take 99 times the fine powder after the above-mentioned sieve Weight of polyethylene glycol 6000 (that is, PEG6000 content is 99% of the weight of the pill) is heated to 50 ° C to make it melt, add the above-mentioned fine powder under stirring, dissolve the natural borneol and menthol with 1ml of dehydrated alcohol and add after slight heating , stirred at 50°C for 30 minutes to make the dispersion uniform, evaporated the absolute ethanol, drained the air bubbles, and transferred the liquid medicine to the 50°C constant temperature ...

Embodiment 2

[0044] Accurately weigh 375 g of sargassum, 0.75 g of natural borneol, and 0.25 g of menthol (sarcodon: natural borneol: menthol=1500: 3: 1); add 20 times the amount of 70% ethanol for sargassum, and heat and reflux 4 times , each time for 1.5 hours, suction filtration while hot, combined filtrates, reclaimed ethanol to the extract with a relative density of 1.15 (20°C), spray-dried into fine powder, crushed the fine powder until all passed through an 80-mesh sieve; The polyethylene glycol 4000 of the same weight of the final fine powder (that is, the PEG4000 content is 50% of the pellet weight) is heated to 90°C to make it melt, and the above fine powder is added under stirring, and the natural borneol and menthol are cryogenically ground to a viscous liquid After adding, stir at 90°C for 15 minutes to disperse evenly, heat at 90°C until the air bubbles are exhausted, transfer the liquid medicine to the 90°C constant temperature storage tank of the dropping pill machine, use a...

Embodiment 3

[0046] Accurately weigh 150 g of sargassum, 0.375 g of natural borneol, and 0.25 g of menthol (sarcodon: natural borneol: menthol=600: 1.5: 1); add 8 times the amount of 70% ethanol for sargassum, and heat and reflux twice , each time for 1.5 hours, suction filtration while hot, combined filtrates, recovered ethanol to the extract with a relative density of 1.20 (20°C), and spray-dried into fine powder; take 40g polyethylene glycol 6000 and heat it to 80°C to melt it, and then Add the above fine powder under stirring, grind the natural borneol and menthol at low temperature to a viscous liquid and add it, stir at 80°C for 15 minutes to disperse evenly, keep warm at 80°C until the air bubbles are exhausted, transfer the liquid medicine to the dropping pill machine at 80°C In the constant temperature storage tank, use a dropping pill machine with a dripper diameter of 2.5 / 3.5mm and a dripper temperature of 80°C for dripping, the drop distance is adjusted to 6cm, the condensing ag...

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Abstract

The invention relates to a dripping pill for treating pharyngitis and its preparing process, wherein the medicament is prepared from glabrous sarcandra herb extract, natural boneol and menthol through steps of ethanol extracting glabrous sarcandra herb, drying into fine powders, heating base material till melting, charging the fine powders while stirring, charging into natural boneol and menthanol, and making dripping pills under condition of thermal insulation.

Description

Technical field: [0001] The invention relates to a preparation of Yanyanqing dripping pills and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique: [0002] Sarcandra glabra Thunb is the whole herb of Sarcandra glabra Thunb, also known as Sarcandra glabra Thunb, also known as Sarcandra glabra Thunb, etc. Antibacterial and anti-inflammatory, heat-clearing and detoxifying, relaxing muscles and promoting blood circulation, etc., has a good curative effect on inflammatory diseases of the oral cavity, respiratory system, and digestive system. Natural borneol and menthol can effectively relieve the pain and itching of the patient's throat. [0003] Acute and chronic pharyngitis is a common and frequently-occurring disease. In order to give full play to the therapeutic effects of sarcophagus, natural borneol and menthol on throat diseases, medical workers have done a lot of research and developed a variety of related drugs, some...

Claims

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Application Information

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IPC IPC(8): A61K36/534A61K9/20A61P11/04A61K31/045
Inventor 况代武
Owner YANTAI DAYANG PHARMA GRP
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