Biocompatible implant for the expression and in vivo secretion of a therapeutic substance

a biocompatible implant and in vivo secretion technology, applied in the field of biocompatible implants for the expression and in vivo secretion of therapeutic substances, can solve the problems of being accompanied by a considerable diminution of vector titers, defective or insufficient expression,
US20020098223A1Inactive Publication Date: 2002-07-25INST PASTEUR
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INST PASTEUR
Publication Date
2002-07-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an implant obtained by assembling in vitro various elements in order to form a neo-organ which is introduced preferably in the peritoneal cavity of the recipient. The implant comprises a biocompatible support intended to the biological anchoring of cells; cells having the capacity of expressing and secreting naturally or after recombination a predetermined compound, for example a compound having a therapeutical interest; and a constituent capable of inducing and / or promoting the geling of said cells. The invention also relates to a kit for the preparation of the implant as well as to a new recombinant retroviral vector comprising a provirus DNA sequence modified in that the genes gag, pol and env have been deleted at least partially so as to obtain a proviral DNA capable of replication. The invention also relates to recombinant cells comprising the new retroviral vector.
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Description

[0001] The invention relates to a biocompatible implant for the expression of defined substances in man or in animals, in particular for the anchoring of the recombinant cells at the invention.

[0002] The present invention also relates to retroviral vectors for the preparation of recombinant cells capable of being implanted in vivo for a therapeutic purposeSTATE OF THE ART

[0003] The in vivo introduction of implants capable of expressing defined substances for example for therapeutic purposes necessitates the use of efficacious agents as regards the desired therapeutic or prophylactic objective and that the organism into which the implant is introduced has the capacity to tolerate it in the relatively long-term.

[0004] The earlier international patent application published under the number 92 / 15676 described agents to obtain in vivo the expression of defined nucleotide sequences for the purpose of a therapeutic treatment of diseases resulting from a genetic anomaly. This international ...

Claims

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