Extended release suspension compositions

a suspension composition and composition technology, applied in the direction of digestive system, metabolism disorder, pharmaceutical non-active ingredients, etc., can solve the problems of inaccurate dosing and/or dose dumping, large compositions, poor patient compliance, etc., to improve patient compliance, facilitate administration, and improve dose flexibility
US20160228379A1Inactive Publication Date: 2016-08-11SUN PHARMA INDS
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
SUN PHARMA INDS
Publication Date
2016-08-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to extended release suspension compositions of an active ingredient. Said extended release suspension compositions comprise multiple coated cores of the active ingredient and a suspension base, wherein the suspension base generates a hypertonic condition such that there is no substantial change in the in-vitro dissolution release profile of the extended release suspension compositions upon storage for at least seven days. The invention also relates to processes for the preparation of said extended release suspension compositions.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to extended release suspension compositions of an active ingredient. Said extended release suspension compositions comprise multiple coated cores of the active ingredient and a suspension base, wherein the suspension base generates a hypertonic condition such that there is no substantial change in the in-vitro dissolution release profile of the extended release suspension compositions upon storage for at least seven days. The invention also relates to processes for the preparation of said extended release suspension compositions.BACKGROUND OF THE INVENTION

[0002] Extended release solid compositions are preferred dosage forms over immediate release solid compositions, especially for active ingredients showing fluctuations in the plasma concentration and for active ingredients having short half-lives. Extended release solid compositions can be in the form of tablets or capsules, wherein the release of the active ingredient is con...

Claims

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