51 results about "Arylpiperazine derivatives" patented technology

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Processes for preparing N-aryl-piperazine derivatives of formula I

particularly (R)-4-cyano-N-[2-[4-(2,3-dihydro-1,4-benzodioxan-5-yl)-1-piperazinyl-propyl]-N-(2-pyridinyl)-benzamide, are disclosed. Compositions comprising N-aryl-piperazine derivatives and low levels of common impurities are also disclosed. In addition, products produced by the process are disclosed.

The present invention relates to novel quinoxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quinoxalin-piperazine compounds are also included.

The invention relates to ten amide arylpiperazine derivatives, their preparation method, and their use in the preparation of benign prostatic hyperplasia treatment medicines. The preparation method of the amide arylpiperazine derivatives comprises the following steps: reacting free alkali of 3-bromopropylamine hydrobromide with di-tert-butyl dicarbonate to obtain a colorless oily liquid, reacting the colorless oily liquid with o-methoxyphenylpiperazine to obtain a light yellow oily material, reacting the light yellow oily material with trifluoroacetic acid to obtain a product, and reacting the product with N,N-diisopropylethylaine, 2-(7-azobenzotriazol)-N,N,N',N'-tetramethylformamidinium hexafluorophosphate, and 5-indoleacetic acid or 3-indoleacetic acid or 3-indolepropionic acid or 3-indolebutyric acid or 5-hydroxy-2-indoleacetic acid or 5-methoxy-2-indoleacetic acid or 1-methyl-3-indoleacetic acid or 6-bromo-2-indoleacetic acid or 5-chloro-2-indoleacetic acid or 7-nitro-2-indoleacetic acid to obtain final products. Experiments prove that the benign prostatic hyperplasia resistance activities of eight compounds in the amide arylpiperazine derivatives are stronger than a contrast drug prazosin.

The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT<1A> acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).

The present invention relates to certain biarylz and arylheteroaryl piperazine derivatives of Formula (Ia) that are modulators of the 5HT_2c receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT_2c receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders.

The invention relates to a novel N-aryl piperazine compound having double activity of dopamine D2 and 5-HT2a, a preparation method, a medicine combination containing the compound and an application thereof on treating mental diseases.

The invention discloses application of an aryl piperazine compound shown in a formula (I) in preparing medicines for treating acute pain, nerve pain and nociceptive pain of mammals including human beings. The medicines are particularly suitable for treating complex pain caused by various reasons.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

The invention provides an N-aryl piperazine derivative, i.e. a compound shown in formula (I) or pharmaceutically acceptable salt, wherein n is 1-6. The invention provides the compound shown in formula (I) and a drug composition thereof which have excellent effect in treating nervous and mental diseases caused by central nervous system dopamine and serotonin transmittance disorder.

An anti-depression 4-[2-(arylthio) benzyl]-1-arylpiperazine derivative used to prepare the medicine for treating depression is prepared through Ullmann reaction between p-methoxy benzeneethiol and p-chlorobenzoic acid to generate thioether, reducing, chlorinating and N-alkylation.

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.