30 results about "Continuous evolution" patented technology

The present invention proposes a Magic and Robust Methodology Integrated-Reengineering (MaRMI-RE), which is a reengineering methodology defining a process including procedures and techniques for a componentization of legacy systems and work products generated during the process. A continuous evolution model for the legacy systems proposed in the present invention enables the legacy systems to be systematically transformed into component systems capable of smoothly complying with new requirements, thus maximizing productivity and efficiency of the legacy systems with respect to potential business and system change requirements.

The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for the continuous evolution of nucleic acids. For example, a lagoon is provided in which a population of viral vectors comprising a gene of interest replicates in a stream of host cells, wherein the viral vectors lack a gene encoding a protein required for the generation of infectious viral particles, and wherein that gene is expressed in the host cells under the control of a conditional promoter, the activity of which depends on a function of the gene of interest to be evolved. Some aspects of this invention provide evolved products obtained from continuous evolution procedures described herein. Kits containing materials for continuous evolution are also provided.

Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and / or positive selection of desired properties.

The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for the continuous evolution of nucleic acids. For example, a lagoon is provided in which a population of viral vectors comprising a gene of interest replicates in a stream of host cells, wherein the viral vectors lack a gene encoding a protein required for the generation of infectious viral particles, and wherein that gene is expressed in the host cells under the control of a conditional promoter, the activity of which depends on a function of the gene of interest to be evolved. Some aspects of this invention provide evolved products obtained from continuous evolution procedures described herein. Kits containing materials for continuous evolution are also provided.

Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and / or positive selection of desired properties.

Strategies, systems, methods, reagents, and kits for phage-assisted continuous evolution are provided herein. These include strategies, systems, methods, reagents, and kits allowing for stringency modulation to evolve weakly active or inactive biomolecule variants, negative selection of undesired properties, and / or positive selection of desired properties.

Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is that the 5′ nucleotide of the target is specific for thymine (T). TALE domains with alternative 5′ nucleotide specificities could expand the scope of DNA target sequences that can be bound by TALEs. This disclosure provides methods and strategies for the continuous evolution of proteins comprising DNA-binding domains, e.g., TALE domains. In some aspects, this disclosure provides methods and strategies for evolving such proteins under positive selection for a desired DNA-binding activity and / or under negative selection against one or more undesired (e.g., off-target) DNA-binding activities. Some aspects of this disclosure provide engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with altered 5′ nucleotide specificities of target sequences. Engineered TALEs that target ATM with greater specificity are also provided.

The invention relates to a realization method for refinement operation system architecture of a valued-added service. The operation steps of the method are as follows: (1), dividing the refinement operation system architecture of the valued-added service into six layers from low to high, wherein the six layers include a data source layer, a data acquisition layer, a data storage layer, a data mining layer, an information gathering layer, and a management application layer; (2), setting functions of the above-mentioned layers in the refinement operation system architecture of the valued-added service, wherein the functions respectively include offer of valued-added service data, acquisition and transition of the valued-added service data, storage of data, mining of off-line and on-line data, gathering of the off-line and on-line information, and man-machine interaction management and refinement of the valued-added service; (3), setting a processing method for data and information in the refinement operation system architecture of the valued-added service. According to the method provided in the invention, an analysis on result data of the mining and rapid application of knowledge can be realized; instant marketing, rapid intervention to malicious behaviors and real-time monitoring on network and service quality can be realized; besides, the system has abilities of dynamic upgrade and continuous evolution.

Compositions and methods for the autonomous in vitro evolution of molecules having specific properties, employing one-pot continuous evolution are disclosed.

The invention discloses an automatic unmanned plane express delivery shortest path program method. The address information of each to-be-delivered express is scanned through scanning equipment, all target sites of a present delivery task are determined, and the shortest path starting from an express distribution center, passing by all the target sites and finally returning back to the express distribution center is programmed. An initialization algorithm is firstly provided, a population including a series of molecules is generated, and each molecule represents a feasible path satisfying the delivery task; four corresponding chemical reaction sub algorithms are further provided, including a decomposition algorithm, a synthesis algorithm, a local search algorithm and a greedy search algorithm, iteration is carried out according to relevant rules, the molecule population is made to realize continuous evolution till iteration termination conditions are satisfied, a molecule of the population having the smallest potential energy is found out, and the optimal path is programmed. The method is advantaged in that on the condition that the delivery task of all the target express sites is accomplished, the total flight path of the unmanned plane is the shortest, the total consumption time is the shortest, consumption energy is effectively reduced, and express delivery efficiency is improved.

Golf is a massive industry as well as sport globally with golfers investing in continuous evolutions and modifications to golf clubs with sensitivity to weight of a few grams, offset in angle of a degree, “feel” etc. Prior art designs focused to the golf club head, grip, and in a few instances the shaft. However, considerations of accurate alignment between the elements during initial assembly / replacement are not addressed. It is, therefore, desirable to provide a means of assembling a golf club shaft that provides for an accurate alignment between the multiple elements such that alignment between them is established, can be maintained with replacements, and also allows for meaningful adjustments in the grip and head to be achieved as multiple other factors do not confound the desired interpretation of the impact of an adjustment. Accordingly the invention provides for such alignment between multiple elements of a golf club.

The present invention discloses wireless communication test system. Said system includes computer main board, more than one data cards, bus conversion unit, wherein data cards, bus conversion unit, and computer main board respectively connected international standard PCMCIA bus and computer bus, computer main board through bus conversion unit PCMCIA bus converting to computer bus, driving and controlling said plurality of data cards, to make wireless communication systematical test. The present invention adapts continuous evolution communication system.

The invention discloses a dynamic fatigue evolution test method for rubber and fiber cord thread bonding, by means of connecting a fixture with an MTS elastomer test system, the method realizes simulation of continuous evolution process of bonding failure of rubber and a fiber cord thread under various conditions of use in multiple modes such as constant stress, constant strain as well as alternating load and alternating frequency. The beneficial effects of the method are that: the method is simple to operate, the data is reliable, the reproducibility is high, the test process has time continuity, so the method can better simulate the evolution process of bonding fatigue rupture of multiple kinds of rubber and various fiber cord thread composite materials under the condition of real stress, and has important guiding significance for predicting the service life of rubber products,thereby having a broad application prospect.

Some aspects of this disclosure provide methods for phage-assisted continuous evolution (PACE) of proteases. Some aspects of this invention provide methods for evaluating and selecting protease inhibitors based on the likelihood of the emergence of resistant proteases as determined by the protease PACE methods provided herein. Some aspects of this disclosure provide strategies, methods, and reagents for protease PACE, including fusion proteins for translating a desired protease activity into a selective advantage for phage particles encoding a protease exhibiting such an activity and improved mutagenesis-promoting expression constructs. Evolved proteases that recognize target cleavage sites which differ from their canonical cleavage site are also provided herein.

The invention discloses a method for performing network security protection on an Internet of things system. The method is characterized in that a security module is connected in series to each Internet of things terminal at a front end of the Internet of things system; an Internet of things system operation and maintenance security supervision platform is connected in series to an Internet of things system server; the security modules perform network communication with the Internet of things system operation and maintenance security supervision platform through information transmission; communication between the Internet of things terminals and the Internet of things system server needs to be performed through the security modules and the Internet of things system operation and maintenance security supervision platform; and communication among the Internet of things terminals needs to be performed through the security modules. The method consists of server-to-end communication security protection, end-to-server communication security protection and end-to-end communication security protection. On the basis of a closed-loop communication security protection system built with the security modules, the Internet of things system operation and maintenance security supervision platform and an information transmission network therebetween, the continuous evolution of the Internet ofthings protection capability and continuous improvement of the security level are ensured.

Golf is a massive industry as well as sport globally with golfers investing in continuous evolutions and modifications to golf clubs with sensitivity to weight of a few grams, offset in angle of a degree, “feel” etc. Prior art designs focused to the golf club head, grip, and in a few instances the shaft. However, considerations of accurate alignment between the elements during initial assembly / replacement are not addressed. It is, therefore, desirable to provide a means of assembling a golf club shaft that provides for an accurate alignment between the multiple elements such that alignment between them is established, can be maintained with replacements, and also allows for meaningful adjustments in the grip and head to be achieved as multiple other factors do not confound the desired interpretation of the impact of an adjustment. Accordingly the invention provides for such alignment between multiple elements of a golf club.

The invention belongs to the field of computer graphics technology and bionics, in particular to a seabed biological cluster simulation method based on a cluster collaborative algorithm and GPU optimization rendering. The method comprises the following main steps: (1) motion simulation: designing and realizing a clustering algorithm based on individual multiple rules, and adding other interferencefactors to influence the movement effect of the cluster, adopting the GPU / CUDA for carrying out optimization operation, and greatly improving the operation efficiency; and (2) scene rendering: adopting a GPU vertex shader to achieve the animation effect of a biological individual, and drawing the scene content by adopting a GPU slice element shader, adopting a GPU transformational feedback technology to draw a particle system in a scene, drawing a realistic submarine scene, and adopting a multi-light-source rendering technology to effectively improve the scene and shadow effect and the stereoscopic impression. According to the invention, the clustering motion algorithm based on the individual rules is achieved based on the GPU, so that the cluster movement can achieve a dynamic balance and continuous evolution state, and a GPU programmable assembly line is adopted, so that the scene rendering is achieved.

The invention discloses a step length progressive reduction-based evolutionary strategy optimization algorithm, which is an intelligent optimization algorithm originating from population competition, reproduction and evolution, and belongs to the technical field of optimization methods. According to the algorithm, a solution of a to-be-optimized problem is represented with an individual in a population, the initial evolutionary intensity is determined by the size of a feasible region of the problem, and an initial evolutionary direction is set to be isotropic. With continuous evolution of the population, the evolutionary intensity and the evolutionary direction of the population gradually adapt to a current environmental pressure, so that a more excellent population can be reproduced by the next generation. The quality of the individual in the population is determined by a fitness value and the environmental pressure is determined by a local form of a fitness function. For a nonlinear optimization problem or convex problem with a large amount of local extreme points, the algorithm has very high solving efficiency, can be converged with any precision and is simple to realize, very good in global search capability and high in convergence speed.

The invention discloses a Chinese semantic library new word generation method. The method comprises the following steps of: setting a text block as a corpus; scanning the text block so as to form adjacent words into a set; if the set is not in a dictionary, carrying out statistical analysis on an occurrence frequency of the set; and if the occurrence frequency exceeds a threshold value, considering the adjacent words as new words and adding the new words into a semantic library. According to the method, the similarities between Chinese texts can be accurately compared, and new words can be rapidly recognized, so that the dictionary is supplemented; along with the continuous development of the society and the continuous evolution of the culture, the Chinese vocabulary is continuously extended; through using the method, recognized new words are added into the dictionary, so that plenty of time and labor are saved.

The invention relates to an automatic evolution method for an intelligent model, and the method comprises the steps: obtaining new service data, and enabling the new service data to be expanded into atrainable data set; Screening out sample data from the expanded trainable data set; Training the intelligent model by using the sample data; And if the trained new intelligent model is superior to the original intelligent model, replacing the original intelligent model with the new intelligent model. According to the method, a set of complete automatic evolution iteration mechanism is provided, manual automatic completion can be replaced on each link of machine learning, evolution of the intelligent model becomes a complete closed loop, continuous evolution can be achieved along with increaseof the number of use times, and higher intelligence is achieved.

The invention discloses a machine learning-based coating embellishing method and system. The method comprises the following steps of: pre-establishing a basic sample card and completing mapping whichhas a formula concentration achieving a tri-stimulus value on the basis of machine learning model training; obtaining a reflection rate of a target color lump, calculating a tri-stimulus value of thetarget color lump, and inputting the reflection rate and the tri-stimulus value into a machine learning model to obtain a current formula result; and making a sample according to the current formula result, calculating an aberration, if the aberration is greater than a preset threshold value, obtaining a tri-stimulus value of the sample, inputting the tri-stimulus value of the sample into the machine learning model to obtain a new formula result, and calculating a new corrected formula result according to the current formula result and the new formula result to serve as a new current formula result. The method is capable of effectively solving the problems of long time consumption, high cost and bad effect in the coating embellishing industry; through importing a machine learning method, the system can obtain satisfied embellishing results in continuous evolution and learning; and the method and system have the advantages of being high in intelligence, high in expansibility and high inprecision.

The invention discloses a novel sprinkling quenching process applied to an aluminum alloy plate. According to the temperature ranges of a plurality of evolution reaction stages in an aluminum alloy material continuous evolution curve CCP and the minimum critical cooling rate of each evolution reaction stage, the cooling rate adjusting stage of the aluminum alloy plate with the temperature range being consistent with the evolution reaction stage temperature range and the cooling rate being consistent with the minimum critical cooling rate is determined; and an aluminum alloy plate workpiece iscooled according to the cooling method. The obtained aluminum alloy plate is high in mechanical property and low in residual stress, the defect that the large residual stress is prone to being causedby aluminum plate quenching through the same cooling rate traditionally and the problem that too large residual stress is caused by discontinuity of step quenching and isothermal insulation method areavoided, and great significance is achieved on promotion of high-quality production of thick aluminum plates of aerospace.

The invention discloses an automatic improvement method of an associated knowledge base. The method comprises the following steps: through modeling for behavior data of a trainer in a training process, finding out a topological structure and association strength among knowledge points through a statistic method, enabling a result to act on an associated knowledge base network through three types of operations including adding, updating and deleting, and realizing 'association' among the knowledge points. Moreover, the automatic improvement method is similar to human memory, by incremental dataobtained continuously, the operations above are continued for improving the knowledge base network, thus, continuous evolution of the knowledge base is realized. Under the premise of confirming to learning lines of learners, the associated knowledge base provided by the invention also can dynamically regulate own structure of the knowledge base according to data in the learning process of the learners, thus, learning efficiency is improved.

The invention discloses an artificial bee colony optimization method based on feasible solution information exchange, and the method employs different information exchange strategies at different stages of a bee colony. In the method, the exchangeable information is from a current population, and is automatically replaced along with the continuous evolution of the method. According to the invention, the method achieves different information exchange search strategies for foraging bees at different stages, and automatically adjusts the searching and development capability of the foraging bees. The method has the quicker and more effective function optimization performance under the same calculation consumption conditions.

The invention discloses a partner robot system based on artificial intelligence, and belongs to the field of robots. The system comprises an information receiving module, an information processing module, a PLC control system, a terminal module, a judging module, a forwarding module, a storage module and a comparison module, wherein the information receiving module, the information processing module, the PLC control system and the terminal module are sequentially connected; the information receiving module comprises a sound acquisition module, a control command module and an image acquisitionmodule; and the information processing module comprises a sound analysis module, a command analysis module and an image analysis module. The invention further discloses the robot using the artificial-intelligence partner robot system. According to robot, self-optimization can be achieved, the gradually-optimized circulation system is formed, the continuous evolution process can be realized, and thus the robot can communicate with people better.

The invention discloses a dynamic fatigue evolution test method of rubber and fiber cord bonding. The method realizes constant stress, constant strain, alternating load and alternating Under various modes such as frequency, the continuous evolution process of the adhesive failure of rubber and fiber cords under various service conditions is simulated. The beneficial effects of the present invention are: the method of the present invention is simple to operate, reliable in data, high in reproducibility, and the test process has continuity in time, so it can better simulate the real test of various rubber and various fiber cord composite materials. The evolution process of bond fatigue failure under stress has important guiding significance for predicting the service life of rubber products, so it has broad application prospects.

The invention provides a wireless multifunctional digital measuring station, facilitates maintenance of function upgrading, updating and continuous evolution of a product, and facilitates improvement of resource utilization of existing data display processing equipment and the like. The wireless functional digital measuring station is characterized in that the wireless functional digital measuring station includes a housing, the housing includes a multifunctional digital measuring circuit part and does not include a data display processing part, a wireless transceiver and a plurality of pairs of jacks are arranged on the housing, the multifunctional digital measuring circuit part includes a plurality of measuring circuits, the plurality of measuring circuits and the plurality of pairs of jacks form a connection relation of one-to-one correspondence, so as to realize respective measuring functions, and the wireless transceiver is used for sending measured data outwards.

The present invention discloses wireless communication test system. Said system includes computer main board, more than one data cards, bus conversion unit, wherein data cards, bus conversion unit, and computer main board respectively connected international standard PCMCIA bus and computer bus, computer main board through bus conversion unit PCMCIA bus converting to computer bus, driving and controlling said plurality of data cards, to make wireless communication systematical test. The present invention adapts continuous evolution communication system.