The invention belongs to the field of
computational lithography, and particularly discloses a
lithography model calibration method based on a proxy model assisted
hybrid genetic algorithm, which comprises the following steps: determining to-be-optimized parameters of a
lithography model, and generating an initial
population according to the to-be-optimized parameters; performing
parallel simulation on the current
population to obtain a photoetching
model simulation result of the current
population; performing parallel evaluation on the current population to obtain photoetching model evaluation indexes and fitness distribution of the current population; screening excellent individuals in the current population to construct an agent model, and performing optimal prediction to obtain a first type of individuals; screening excellent individuals in the current population and carrying out
crossover and variation to obtain a second type of individuals; and combining the first type of individuals and the second type of individuals, carrying out
parallel simulation and evaluation on the next-generation population, and carrying out loop iteration updating until a preset termination condition is met, so as to obtain a photoetching
model parameter set of the optimal individual. According to the invention, the calibration process of the photoetching model can be simplified, and the
automation, precision efficiency and global search capability are improved.