The invention discloses herbicide special for wheat and a preparation method of the herbicide. The herbicide is prepared from ethylene oxide, chlorimuron-methyl, metsulfuron-methyl, tribenuron-methyl, sodium polyacrylate, diuron, isopropyl N-(3-chlorophenyl)carbamate, fluazifop-butyl, fluorine cyanide, paraquat, kaolin, a surface active agent, fungicide, a herba leonuri extraction solution, a rhizoma pinelliae extraction solution, rhizoma atractylodis macrocephalae leach liquor, Chinese yam leach liquor, radix scrophulariae leach liquor, licorice root leach liquor, radix saposhnikoviae leach liquor, radix astragali leach liquor, radix bupleuri leach liquor, radix salviae miltiorrhizae leach liquor, rhizoma anemarrhenae leach liquor, carbonate, tripterygium wilfordii and radix stemonae. The raw materials are reasonable in matching and easy to obtain and are all harmless non-chemical components, the herbicide is pure natural and free of pollution, can prevent and treat various types of weeds, and is good in weeding effect, wide in weeding spectrum, free of harms to the environment and humans and suitable for being applied and popularized, cost is low, and thus the herbicide does not influence plantation of organic food and is good in absorption and convenient to use and popularize.