37results about How to "Eliminate or reduce at least one drawback of the prior art" patented technology

A system comprising a state changing appliance and a drug delivery device, the state changing appliance comprising first interface means for rotationally locking to a first exterior portion of the drug delivery device, second interface means for rotationally locking to a second exterior portion of the drug delivery device, the first exterior portion and the second exterior portion being angularly displaceable relative to one another from a first relative position to a second relative position, which second relative position defines a set dose to be expelled by the drug delivery device, and limiter means for limiting a relative angular displacement between the first interface means and the second interface means.

A system comprising a state changing appliance and a drug delivery device, the state changing appliance comprising first interface means for rotationally locking to a first exterior portion of the drug delivery device, second interface means for rotationally locking to a second exterior portion of the drug delivery device, the first exterior portion and the second exterior portion being angularly displaceable relative to one another from a first relative position to a second relative position, which second relative position defines a set dose to be expelled by the drug delivery device, and limiter means for limiting a relative angular displacement between the first interface means and the second interface means.

A drug delivery device (1, 200) comprising a drug delivery unit (10, 210) comprising a housing (12, 212) extending along a general axis, a variable volume reservoir (40′, 40, 140, 240), and a needle support (50′, 50, 150, 250) for receiving a needle assembly (30′, 30, 130, 230), the needle support (50′, 50, 150, 250) and the variable volume reservoir (40′, 40, 140, 240) being capable of diverging relative axial motion from a first relative position to a second relative position and converging relative axial motion from the second relative position to the first relative position, a cap (20, 120, 220) removably mountable onto the drug delivery unit (10, 210) to cover at least a portion of the needle support (50′, 50, 150, 250), and a coupling mechanism configured to bring the needle support (50′, 50, 150, 250) and the variable volume reservoir (40′, 40, 140, 240) from the first relative position to the second relative position in response to the cap (20, 120, 220) being mounted onto the drug delivery unit (10, 210).

The present invention provides a drug injection device (1) comprising a housing (2) extending along a longitudinal axis and comprising an exterior housing surface, an activation element (20, 50) configured to undergo movement relative to the housing (2) corresponding to an action performed on or by the drug injection device (1), a transducer (90, 91, 92) arranged on a transducer bearing portion (8.1, 9.1, 9.2) of the exterior housing surface, a processor (82) electrically connected with the transducer (90, 91, 92), and an energy source (95). The transducer bearing portion (8.1, 9.1, 9.2) is capable of deflection relative to other portions of the exterior housing surface, the activation element (20, 50) is arranged to deflect the transducer bearing portion (8.1, 9.1, 9.2) in accordance with said movement relative to the housing (2), the transducer (90, 91, 92) is adapted to register a deflection of the transducer bearing portion (8.1, 9.1, 9.2), and the processor (82) is configured to count deflections registered by the transducer (90, 91, 92).

The present invention provides a drug delivery device (2, 3; 102) for sequential administration of substances, comprising a first variable volume reservoir (40a; 140a) holding a first substance and comprising a first outlet (41a, 141a) and a first displaceable wall (43a; 143a), a second variable volume reservoir (40b; 140b) holding a second substance and comprising a second outlet (41b; 141b) and a second displaceable wall (43b; 143b), a first wall actuation structure (65a, 70a, 75a, 77a; 177a) activatable to move the first displaceable wall (43a; 143a) and thereby expel a dose of the first substance through the first outlet (41a; 141a), a second wall actuation structure (65b, 70b, 75b, 77b; 177b) activatable to move the second displaceable wall (43b; 143b) and thereby expel a dose of the second substance through the second outlet (41b; 141b), and a drive structure (90; 190) for activating the first wall actuation structure (65a, 70a, 75a, 77a; 177a) and the second wall actuation structure (65b, 70b, 75b, 77b; 177b). The drive structure (90; 190) performs a predetermined movement during one sequential administration of the first substance and the second substance, the predetermined movement comprising a first part movement followed by a second part movement, and is configured to activate the first wall actuation structure (65a, 70a, 75a, 77a; 177a) during the first part movement and to activate the second wall actuation structure (65b, 70b, 75b, 77b; 177b) during the second part movement.

The present invention provides an injection needle unit (10) comprising: a needle assembly (20) comprising: an injection needle (25) extending along a longitudinal axis and having a distal needle end configured for insertion into a subject and a proximal needle end configured for penetration of a reservoir septum, and a skirt (22) surrounding the proximal needle end and defining a receiving space (28) for reception of a needle mount of a drug delivery device, the skirt (22) comprising a slot (24), and a block structure (32) supported exteriorly of the skirt (22), wherein the block structure (32) is biased towards the longitudinal axis and is capable of radial displacement through the slot (24) from a latched position outside the receiving space (28) to a released position within the receiving space (28).

The present invention provides a drug reservoir (1) comprising a reservoir body (2) extending between an outlet end (4) and a proximal end (7), a front piston (8) arranged in a pre-use position within the reservoir body (2) between the outlet end (4) and the proximal end (7), a rear piston (9) arranged within the reservoir body (2) between the front piston (8) and the proximal end (7) a distal chamber (10) defined by the outlet end (4), a first portion of the reservoir body (2), and the front piston (8), the distal chamber (10) holding first contents (18), a proximal chamber (11) defined by the front piston (8), a second portion of the reservoir body (2), and the rear piston (9), the proximal chamber (11) holding second contents (12, 19) comprising a proximal liquid volume (19), and bypass means (3) allowing fluid flow past the front piston (8) in an advanced position of the front piston (8) in the reservoir body (2), wherein the second contents (12, 19) further comprises a proximal gas volume (12) lying within a volume range having a predetermined minimum value.

The present invention provides a sensor module (50) adapted to be arranged in a cartridge based drug delivery device between a rotatable piston rod and a cartridge piston. The sensor module (50) comprises a first sensor structure (52, 152, 252, 352) adapted to be at least substantially rotationally locked with respect to the cartridge piston and comprising a transversal sensor surface (52.2, 152.2, 252.2, 352.2), and a second sensor structure (53, 153, 253, 353) adapted to be rotationally locked with respect to the piston rod and comprising one or more flexibly supported and axially deflectable contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2), which are positioned distally of the transversal sensor surface (52.2, 152.2, 252.2, 352.2) and are adapted to apply a proximally directed force thereto. The first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) are adapted to undergo relative rotational motion, whereby the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2). A processor (52.5, 152.5, 252.5) determines a relative angular displacement between the first sensor structure (52, 152, 252, 352) and the second sensor structure (53, 153, 253, 353) from signals generated as the one or more contact members (53.1, 53.2, 153.2, 253.2, 353.1, 353.2) sweep the transversal sensor surface (52.2, 152.2, 252.2, 352.2).

The present invention provides a piston washer (1, 51) for a drug delivery device, the piston washer (1, 51) comprising a central portion (2, 72) arranged about a centre axis, a peripheral portion (3, 73), and an axially pliable structure (8, 78) connecting the central portion (2, 72) and the peripheral portion (3, 73). The axially pliable structure (8, 78) is preconfigured to undergo permanent deformation in response to a difference between a first resultant force acting on the peripheral portion (3, 73) and a second resultant force acting on the central portion (2, 72) exceeding a threshold level. The piston washer (1, 51) is configured to transition permanently by deformation of the axially pliable structure (8, 78) from a first state in which the central portion (2, 72) and the peripheral portion (3, 73) are physically connected and assume a first relative axial position to a second state in which the central portion (2, 72) and the peripheral portion (3, 73) are physically connected and assume a second relative axial position in response to the difference between the first resultant force and the second resultant force transiently exceeding the threshold level.

The present invention provides a needle unit (10) for use with a pen injection device, wherein the needle unit (10) comprises a needle shield (50) and an axially movable needle hub (25).

The present invention provides a needle assembly (1) for a drug delivery device, comprising a needle hub (25) in which a needle (15) is fixedly mounted, the needle (15) extending along a reference axis and comprising a needle body with a lumen and a distal needle end portion adapted for insertion through a skin layer, a needle shield (12) axially displaceable relative to the needle hub (25) between an extended position in which the distal needle end portion is covered and a retracted position in which the distal needle end portion is exposed, the nee-dle shield (12) being biased towards the extended position, and an elastomeric plug member (10) fitted tightly around a portion of the needle (15), the plug member (10) comprising a self-sealing front section (10.4) and being axially displaceable along the needle body be-tween a proximal plug position in which the distal needle end portion is exposed and a distal plug position in which the distal needle end portion is covered and the lumen is sealed by the self-sealing front section (10.4), wherein the needle shield (12) and the plug member (10) comprise mutually interactable engagement members (12.1, 12.4, 10.5) configured to ensure displacement of the plug member (10) from the proximal plug position to the distal plug position in response to a displacement of the needle shield (12) from the retracted posi-tion to the extended position.

The present invention provides a drug delivery device (1) of the type in which a piston rod (10, 110) extends along a reference axis and is forced to rotate in an expelling direction about the reference axis during a dose expelling event to cause an expelling of drug from a drug reservoir (30, 130), and a resilient ratchet element (12) is operatively coupled with the piston rod (10, 110) and undergoes a deflecting motion comprising elastic deformation and recovery in response to an expelling of a predetermined dose increment, which deflecting motion occasions a velocity fluctuation of the piston rod (10, 110), comprising: a rotator module (50, 150) operatively coupled with the piston rod (10, 110) and configured to rotate about the reference axis against a rotation resisting force in response to a rotation of the piston rod (10, 110) in the expelling direction, the rotator module (50, 150) comprising a sensor system (70, 71; 170, 183; 270, 183) for monitoring a torque transferred by the piston rod (10, 110) during the dose expelling event, wherein the sensor system (70, 71; 170, 183; 270, 183) is configured to, from the monitored torque, identify occurrences of velocity fluctuation of the piston rod (10, 110) attributable to the deflecting motion of the resilient ratchet element 15 (12).

The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rotation with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, moving the variable volume drug reservoir proximally relative to the housing to a completely mounted position, and shifting the piston rod guide irreversibly to a second state in which rotation of the piston rod guide in the second direction relative to the housing is prevented.

The present invention provides a drug injection device (1) for delivering multiple doses of drug, comprising: a housing (2) extending along a main axis, a dose expelling mechanism comprising a piston rod (60) configured to move relative to the housing (2) from a first position to a second position to cause ejection of a dose of drug, the piston rod (60) extending between a proximal piston rod end and a distal piston rod end and comprising a dosing track (63), the piston rod (60) further being movable relative to the housing (2) from an initial pre-use position to a final end stop position to cause accumulated ejection of a predefined total dose, a dosing track follower (17) fixed with respect to the housing (2) and adapted to travel the dosing track (63) during dose ejection, a dose setting mechanism operable to set the dose to be ejected by the dose expelling mechanism, electronic means (82, 90, 91, 92, 95) for registering a dose setting operation and for registering a dose size of an ejected dose, and a display (81) adapted to indicate a size of a current set dose, the electronic means (82, 90, 91, 92, 95) being configured to provide a first type of update of the display (81) responsive to dose changing operations of the dose setting mechanism, wherein the electronic means (82, 90, 91, 92, 95) is further configured to calculate a current accumulated dose from the dose sizes of registered ejected doses to thereby provide an updated value of a total amount of drug ejected, determine a current remaining dose by comparing the current accumulated dose and the predefined total dose, and provide a second type of update of the display (81) when during a dose increasing operation of the dose setting mechanism the current set dose exceeds the current remaining dose, the second type of update being different from the first type of update, and wherein the final end stop position is defined by a track end configuration of the dosing track (63) between the proximal piston rod end and the distal piston rod end.

The present invention provides a drug delivery device (1) comprising a drug delivery unit (10) comprising a dose expelling mechanism operable to expel a dose of drug from a drug reservoir (11), a cap (20) configured for dismountable mounting over a portion of the drug delivery unit (10), the cap (20) comprising a cavity (25, 26) for reception of the portion of the drug delivery unit (10), a seal (40) adapted to provide a sealing in an interface between the cap (20) and the drug delivery unit (10), a sensor system (30) configured to monitor internal pressure in the cavity (25, 26) and to register an event in response to sensing a change in the internal pressure which numerically exceeds a specified threshold level over a period of less than 5 seconds, and energy means (50) for powering the sensor system (30).