32results about How to "Reduced discrimination" patented technology

Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.

Materials and methods are provided for producing aptamer therapeutics having modified nucleotide triphosphates incorporated into their sequence.

The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and / or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.

Hierarchical modulation preferably uses a 16-ary quadrature amplitude modulation (QAM) modulator with a convolutional encoder that combine to effectively provide unequal protection to two different segments of streaming input data, with improved power efficiency with the same bandwidth efficiency, by encoding the first segment as coded data as LSBs as the second segment remains uncoded as uncoded MSBs, with the MSBs used for QAM constellation modest reliability interquadrant demodulation and detection, and with the LSBs used for low reliability intraquadrant detection, but with the LSBs subject to convolutional encoding and decoding rendering the LSBs with high reliability detection, such that, the two segments have unequal coding and modulation for providing unequal levels of reliability detection.

A flame-retardant and fireproof cigarette which aims to contain the combustion process to the cigarette. The flame-retardant and fireproof cigarette has a filter that is aligned with a tobacco body. A flame-retardant and fireproof covering is positioned over at least a portion of the tobacco body and isolates the open fire associated with the consumption of the tobacco during the course of smoking or burning the cigarettes. Such a cigarette reduces the risk of undesired, inadvertent, and latent ignition of adjacent materials.

The present invention relates to an injector for use in gas phase analytical systems and methods comprising a metal housing, provided with a carrier gas inlet, a split outlet, a column outlet of the injector, a sample inlet, a liner, and a heater device comprising at least one coil for radio frequency inductive heating the housing with a predetermined temperature program and for providing a predetermined spatial temperature profile in the injector. The injector according to the invention allows performing gas phase analyses, especially GC analyses with reduced discrimination. Advantages of heating with a heater device comprising a coil for inductive heating include a homogeneous heating profile of the housing including parts connected thereto, with heating rates that can be varied widely. A further advantage is that the injector can be operated as a conventional S / SL injector at a predetermined temperature, or as PTV injector or thermal desorption injector with certain predetermined temperature programs. The invention also relates to a process of making an injector according to the invention, and to a process of refitting an existing S / SL injector. The invention further concerns a gas analytical system comprising an injector according to the invention, and to a process of analysing a sample with such gas analytical system.

An image pickup apparatus includes a photographing optical system; a photographing preparation manipulation judgment device; a photographing implementing manipulation judgment device; a timer adapted for counting a time period from outputting of a signal from the photographing preparation manipulation judgment device to outputting of the signal from the photographing implementing manipulation judgment device; a focus driving device for changing a focused state of an object by changing a positional relation of the lens relative to an image pickup face; an auto focusing (AF) data detector for detecting AF data representative of a distance face up to the object or the focused state of the object; a time-series AF data collector for driving the AF data detector at an interval of a present time period and obtaining the AF data in a chronological manner; and an object movement presumption calculator for presuming changes in distance of the object from the time-series AF data calculating focus moving amount. When the time counted by the timer is not larger than the preset time period, auto focusing operation is implemented based on the focus moving amount calculated by the object movement presumption calculator.

The invention discloses a digital signal transmitting method based on modulated carriers of equal amplitude and equal period, comprising the steps of: sampling two basic wave shapes of f0(t) of 0 representation information and f1(t) of 1 representation information within a period; respectively selecting a storage area which corresponds to f0(t) or f1(t) by a control selection switch of binary information to be transmitted within a wave shape period; converting wave shape samples in the storage area into modulated high-frequency simulating signals under the control of a synchronous clock; transmitting the modulated high-frequency simulating signals subjected to up-conversion modulation, filtering and power amplification; and demodulating the modulated signals before up-conversion on a transmitting end by adopting a demodulating method based on small phase difference or a demodulating method based on zero-crossing detection after the down-conversion of the received signals. The invention also discloses special equipment for implementing the method. A high-efficiency modulating system of equal amplitude and equal period realized by the method further enhances frequency band utilization ratio, ensures the constant performance of the amplitude of the modulating wave shapes, and also strengthens the capability of resisting channel distortion and noise disturbance.

The invention relates to compositions and methods utilizing split polymerase enzymes composed of at least two discrete polypeptides that stably associate to form a single polymerase. The invention further relates to nucleic acid constructs for expressing the split polymerases of the invention, and methods for using the split polymerases of the invention. The enzymes of the invention are useful in many applications calling for the detectable labeling of nucleic acids and are particularly useful in quantitative PCR (QPCR) and DNA sequencing applications.

An antenna system comprises an antenna feed support and a driver. The antenna feed support is configured to mount a circularly polarized antenna feed to an antenna dish to extend outward along a longitudinal axis of the circularly polarized antenna feed with respect to a reflective surface of the antenna dish. The driver is configured to rotate the circularly polarized antenna feed to adjust alignment between the circularly polarized antenna feed and a remote antenna. The driver can rotate the circularly polarized antenna feed mechanically, electrically or both to adjust alignment between the circularly polarized antenna feed and a remote antenna to reduce cross-pol discrimination at the circularly polarized antenna feed.

The invention discloses a compound signal transmission and communication method based on an equal-amplitude equal-period modulated carrier wave technology, which comprises two parts, including the compound transmission of an analog signal and digital information and compound information receiving demodulation, wherein the compound transmission of the analog signal and the digital information comprises the following steps of coding an information source, coding a channel, forming a carrier wave, modulating a base band and modulating upper frequency conversion; in the carrier wave formation, a wave shape of a carrier wave is directly changed by a binary system information code element; compared with a standard sinusoidal wave, a modulated wave shape f1(t) generated when an information bit is one and a modulated wave shape generated when the information bit is zero have an adjustable tiny difference; and the compound information receiving demodulation comprises the following steps of demodulating lower frequency conversion, the analog signal and the digital information, decoding the channel and decoding the information source. The method realizes the compound transmission of the analog signal and the digital information and improves the utilization ratio of communication and transmission resources.

A method of training a computer system for use in determining a transformation between coordinate frames of image data representing an imaged subject. The method trains a learning agent according to a machine learning algorithm, to determine a transformation between respective coordinate frames of a number of different views of an anatomical structure simulated using a 3D model. The views are images containing labels. The learning agent includes a domain classifier comprising a feature map generated by the learning agent during the training operation. The classifier is configured to generate a classification output indicating whether image data is synthesized or real images data. Training includes using unlabeled real image data to training the computer system to determine a transformation between a coordinate frame of a synthesized view of the imaged structure and a view of the structure within a real image. This is done whilst deliberately reducing the ability of the domain classifier to discriminate between a synthesized image and a real image of the structure.

The invention relates to genetical modification of DNA polymerase to reduce its innate selective sequence-related discrimination against incorporation of fluorescent dye-labeled ddCTP and ddATP in the enzymatic reaction for preparation of samples for automated florescent dye-labeled terminator DNA sequencing. The modified DNA polymerases are more resistant to heat inactivation and are more effective in dideoxynucleotide incorporation than current DNA polymerases.

A method of training a computer system for use in determining a transformation between coordinate frames of image data representing an imaged subject. The method trains a learning agent according to a machine learning algorithm, to determine a transformation between respective coordinate frames of a number of different views of an anatomical structure simulated using a 3D model. The views are images containing labels. The learning agent includes a domain classifier comprising a feature map generated by the learning agent during the training operation. The classifier is configured to generate a classification output indicating whether image data is synthesized or real images data. Training includes using unlabeled real image data to training the computer system to determine a transformation between a coordinate frame of a synthesized view of the imaged structure and a view of the structure within a real image. This is done whilst deliberately reducing the ability of the domain classifier to discriminate between a synthesized image and a real image of the structure.

The present invention relates to an engineered polymerase with an expanded substrate range characterised in that the polymerase is capable of incorporating an enhanced occurrence of detection agent-labelled nucleotide analogue into nucleic acid synthesised by that engineered polymerase as compared with the wild type polymerase from which it is derived.

The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and / or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.

A disk apparatus includes: a kind discrimination unit for discriminating the kind of a loaded disk; a designation unit by which the user designates the prior order for discriminating the kind of the disk; and a frequency of use of storage unit for counting and storing a frequency of use of each kind of disks used in the past, wherein the kind discriminating unit is adapted to discriminate when the frequency of use of each kind of disk stored in the frequency of use storage unit exceeds a preset reference level indicating the predetermined tendency of use the kind of the disk in accordance with a priority order according to the tendency of use thereof, and discriminate when the tendency of use is not higher than the mentioned reference level the kind of the disk in the priority order designated by the designation unit.

A flame-retardant and fireproof cigarette which aims to contain the combustion process to the cigarette. The flame-retardant and fireproof cigarette has a filter that is aligned with a tobacco body. A flame-retardant and fireproof covering is positioned over at least a portion of the tobacco body and isolates the open fire associated with the consumption of the tobacco during the course of smoking or burning the cigarettes. Such a cigarette reduces the risk of undesired, inadvertent, and latent ignition of adjacent materials.

An image processing apparatus includes an extraction unit that extracts, from among a plurality of designated regions in which labels of classes are designated, complicated regions which are regions of at least a part of the designated regions and are regions having relatively complicated contours, in an annotation image given as learning data to a machine learning model for performing semantic segmentation in which a plurality of the classes in an image are discriminated on a per-pixel basis, and a setting unit that sets additional labels for the complicated regions separately from original labels originally designated for the annotation image.

A disk apparatus includes: a kind discrimination unit for discriminating the kind of a loaded disk; a designation unit by which the user designates the prior order for discriminating the kind of the disk; and a frequency of use of storage unit for counting and storing a frequency of use of each kind of disks used in the past, wherein the kind discriminating unit is adapted to discriminate when the frequency of use of each kind of disk stored in the frequency of use storage unit exceeds a preset reference level indicating the predetermined tendency of use the kind of the disk in accordance with a priority order according to the tendency of use thereof, and discriminate when the tendency of use is not higher than the mentioned reference level the kind of the disk in the priority order designated by the designation unit.

This invention improves the accuracy of wobble signal detection for disc discrimination and reduces discrimination errors due to noise. In an optical disc apparatus, a wobble signal generator creates a wobble signal from an electrical signal which has been obtained from conversion by a pickup. A bandpass filter (BPF) is set to change its central frequency to a wobble frequency f0 and to fn different from the wobble frequency, and the filter extracts the respective frequency components from the wobble signal. An amplitude-measuring section measures amplitude levels A0 and An of the extracted multiple signals. A disc discriminator compares the multiple amplitude levels and if the amplitude A0 is greater than the amplitude An by at least a threshold level Ath, judges that a wobble is present.