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Composite tri-dimensional porous bone tissue engineering stent material and its preparation method and uses

A bone tissue engineering and scaffold material technology, applied in the field of biomedical materials, can solve the problems of destroying the degradation performance of calcium-phosphorus ceramics, difficult body degradation, poor clinical operability, etc., and achieve good osseointegration and cell affinity, high Bioactivity and biocompatibility, effect of changing structure and mechanical strength

Inactive Publication Date: 2007-12-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tissue engineering provides an emerging approach for the repair of damaged bone tissue. Calcium phosphate ceramics represented by hydroxyapatite (HA) are widely used as bone substitute materials because of their similar chemical composition to the inorganic phase of bone. The disadvantage is that it is difficult to use in load-bearing parts due to its brittleness and low bending strength. After calcination, the crystallinity of ceramics is high and it is difficult for the body to degrade. The resulting stress shielding is very unfavorable to bone healing and shaping.
Collagen has inherent defects as a bone graft substitute: its low mechanical strength cannot better meet the strength requirements of bone repair materials, and its clinical operability is poor
At present, most calcium phosphate / collagen composites are actually mechanical mixtures of the two, which are usually made by grinding sintered HA or other ceramics and mixing them with collagen solution. Forming a tight bond, the ceramic particles can only be loosely distributed in the collagen framework, which cannot solve the problems of bioceramics
In addition, the forming process of traditional hydroxyapatite and other calcium-phosphorus ceramics usually requires high temperature and high pressure, and pressing and sintering further destroy the degradation performance of calcium-phosphorus ceramics.

Method used

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  • Composite tri-dimensional porous bone tissue engineering stent material and its preparation method and uses

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Experimental program
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Effect test

Embodiment 1

[0040] (1) Preparation of CaO-P 2 o 5 -SiO 2 System bioactive glass nanopowder

[0041] (1) Preparation of microemulsion organic template: add octylphenol-based polyoxyethylene ether (TritonX-100), co-surfactant and ammonium hydroxide aqueous solution (concentration 12.5%) or calcium nitrate aqueous solution (concentration 12.5%) in cyclohexane 0.6M), prepare the microemulsion of ammonium hydroxide solution and the microemulsion of calcium nitrate solution;

[0042] (2) Hydrolysis: adding ethyl orthosilicate (TEOS) and triethyl phosphate (TEP) to the microemulsion of ammonium hydroxide solution, a hydrolysis reaction occurs, and the hydrolysis reaction time is 30 to 60 minutes. Ethyl orthosilicate (TEOS): triethyl phosphate (TEP): the weight ratio of ammonium hydroxide aqueous solution is 9: 1: 50;

[0043] (3) mixing: the microemulsion of the calcium nitrate solution configured in step (1) is added in the microemulsion obtained in step (2) by volume ratio 1: 1, and stirre...

Embodiment 2

[0051] (1) Preparation of CaO-P 2 o 5 -SiO 2 System bioactive glass nanopowder

[0052] (1) Preparation of microemulsion organic template: add octylphenol-based polyoxyethylene ether (TritonX-100), co-surfactant and ammonium hydroxide aqueous solution (concentration 12.5%) or calcium nitrate aqueous solution (concentration 12.5%) in cyclohexane 0.6M), prepare the microemulsion of ammonium hydroxide solution and the microemulsion of calcium nitrate solution;

[0053] (2) Hydrolysis: Add ethyl orthosilicate (TEOS) and triethyl phosphate (TEP) to the microemulsion of ammonium hydroxide solution, hydrolysis reaction occurs, the hydrolysis reaction time is 30 minutes, and ethyl orthosilicate (TEOS) ): triethyl phosphate (TEP): the weight ratio of ammonium hydroxide aqueous solution is 13: 1: 100;

[0054] (3) mixing: the microemulsion of the calcium nitrate solution configured in step (1) is added in the microemulsion obtained in step (2) by volume ratio 1: 1, and stirred for 8...

Embodiment 3

[0062] (1) Preparation of CaO-P 2 o 5 -SiO 2 System bioactive glass nanopowder

[0063] (1) Preparation of microemulsion organic template: add octylphenol-based polyoxyethylene ether (TritonX-100), co-surfactant and ammonium hydroxide aqueous solution (concentration 12.5%) or calcium nitrate aqueous solution (concentration 12.5%) in cyclohexane 0.6M), prepare the microemulsion of ammonium hydroxide solution and the microemulsion of calcium nitrate solution;

[0064] (2) Hydrolysis: adding ethyl orthosilicate (TEOS) and triethyl phosphate (TEP) to the microemulsion of ammonium hydroxide solution, a hydrolysis reaction occurs, and the hydrolysis reaction time is 30 to 60 minutes. Ethyl orthosilicate (TEOS): triethyl phosphate (TEP): the weight ratio of ammonium hydroxide aqueous solution is 9: 1: 50;

[0065] (3) mixing: the microemulsion of the calcium nitrate solution configured in step (1) is added in the microemulsion obtained in step (2) by volume ratio 1: 1, and stirre...

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Abstract

The bionic composite 3D bone tissue engineering rack material has pores of 200-500 microns and porosity over 80 %, and contains bioactive nanometer CaO-P2O5-SiO2 glass powder 50-80 wt%, type-I collagen 10-35 wt%, hyaluronic acid 2-8 wt% and phosphatidylserine 2-8 wt%. Its preparation process includes mixing the above said components homogeneously, adding buffering agent and cross-linking agent for cross-linking treatment, freezing, freeze drying to dewater completely, soaking in Na2HPO4 solution, washing, dewatering and vacuum drying. The material is used as bone substituting material for repairing damaged bone tissue in medical field.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a method for preparing a bionic composite three-dimensional porous bone tissue engineering scaffold material. [0002] The invention also relates to materials prepared by said method. [0003] The invention also relates to the use of said materials. Background technique [0004] Tissue engineering provides an emerging approach for the repair of damaged bone tissue. Calcium phosphate ceramics represented by hydroxyapatite (HA) are widely used as bone substitute materials because of their similar chemical composition to the inorganic phase of bone. The disadvantage is that it is difficult to use in load-bearing parts due to its brittleness and low bending strength. After calcination, the ceramics have high crystallinity and are difficult to degrade by the body. The resulting stress shielding is very unfavorable to bone healing and shaping. Therefore, currently commonly used bioceramics re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/56
Inventor 王迎军陈晓峰赵娜如杨春蓉
Owner SOUTH CHINA UNIV OF TECH