Method for preparing anchoic acid by microwave reaction
A microwave reaction, azelaic acid technology, applied in the preparation of carboxylates, chemical instruments and methods, preparation of organic compounds, etc., can solve the problems of low yield, low product purity, complicated post-processing, etc., and achieve the reaction process. Simple, non-polluting, environment-friendly effect
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Embodiment 1
[0039] 386.95g of oleic acid (73% by mass, 1.00mol in moles) and 1.92g of tungstic acid (0.0077mol in moles) were stirred and mixed evenly, and the temperature was raised. When the temperature rose to 55°C, 5% concentration was added dropwise. Hydrogen oxide 1156g (mole number 1.71mol) solution was added dropwise in 10 minutes, and the temperature was raised to 60°C. After reacting for 30 minutes, 5776g (mole number 3.80mol) of 5% peracetic acid was added and put into a microwave device. First preheat with low heat for 5 minutes, and then react for 1 hour under medium heat. After the reaction is over, extract 56.50 g of the product azelaic acid from the reaction solution through extraction, filtration, and drying. The yield (in terms of oleic acid) 30.0%, melting point 106-108°C. At the same time, 41.0 g of nonanoic acid was obtained as a by-product, with a yield (based on oleic acid) of 26.0%.
Embodiment 2
[0041] With oleic acid 386.95g (mass percentage composition is 73%, mole number 1.00mol) 2.90g tungstic acid 2.50g (mole number 0.010mol), tert-butanol 467g (mole number 6.30mol), stir and mix uniformly, heat up, when When the temperature rose to 60°C, a solution of 782.0 g (2.30 mol in moles) of 10% hydrogen peroxide was added dropwise, and the dropwise addition was completed in 15 minutes, and the temperature was raised to 65°C. After reacting for 40 minutes, tert-butanol was recovered by rotary evaporation. Add 15732g peroxybenzoic acid (5.70mol moles) with a concentration of 5% to the oil phase where tert-butanol is removed, put it in a microwave device, preheat it with a small fire for 8 minutes, and then react for 3 hours under a medium fire After the reaction, 75.3 g of the product azelaic acid was extracted from the reaction solution through extraction, filtration and drying, with a yield (calculated as oleic acid) of 40% and a melting point of 106-108° C. At the same ...
Embodiment 3
[0043] With oleic acid 386.95g (mass percentage is 73%, molar number 1.00mol) tungstic acid 3.90g (molar number 0.012mol), isoamyl alcohol 837g (molar number 9.5mol), stir and mix uniformly, heat up, when temperature rises When the temperature reached 65°C, a solution of 317.3g (2.8mol moles) of 30% hydrogen peroxide was added dropwise, and the dropwise addition was completed in 20 minutes, and the temperature was raised to 70°C. After reacting for 60 minutes, isoamyl alcohol was recovered by rotary evaporation. It is 5% peroxyformic acid 9424g (mole number 7.60mol) that adding concentration is 5% in the oily phase that evaporates isoamyl alcohol, puts into microwave device, preheats 10 minutes with low firepower earlier, reacts 1 hour under medium fire then, After the reaction, 103.50 g of the product azelaic acid was extracted from the reaction liquid through extraction, filtration and drying, with a yield (calculated as oleic acid) of 55.0% and a melting point of 106-108°C. ...
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