Method for preparing benzodiazepine molecule surface blotting solid-phase extractant

A solid-phase extraction agent and surface imprinting technology, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve the leakage of template molecules, unsatisfactory mass transfer rate, and affect the accurate quantification of trace analytes Detection and other problems, to achieve the effect of eliminating the interference of impurities, good selection of adsorption and separation capabilities, and not easy to fragment
CN100540135CInactive Publication Date: 2009-09-16SOUTH CHINA NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOUTH CHINA NORMAL UNIVERSITY
Publication Date
2009-09-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The preparation method of the surface imprinted solid-phase extractant of benzodiazepine-like molecules comprises firstly dissolving the benzodiazepine-like template molecules in methanol, then adding functional monomer A and functional monomer B, stirring and pre-acting to obtain a prepolymer, Add tetramethoxysilane or tetraethoxysilane to the above solution, stir evenly, then add silica gel particles activated by methanesulfonic acid solution, add acid to catalyze hydrolysis condensation, filter and dry to obtain the crude product, and finally elute and purify the crude product. The preparation process of the method is simple, and the prepared surface molecular imprinted solid-phase extraction agent has selective recognition for target molecules, can completely eliminate the interference of impurities in samples, has high mechanical strength, stable physical and chemical properties, and small swelling coefficient.
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Description

1. Technical field

[0001] The present invention relates to a kind of benzodiazepine The preparation method of the molecularly imprinted solid-phase extraction agent of class drug, promptly combines sol-gel method and surface imprinting technology, prepares a kind of p-benzodiazepine Drug-like organic-inorganic hybrid solid-phase extraction materials with selective recognition. The extractant is applied to the separation and enrichment of benzodiazepines in biological samples drugs. The invention belongs to the technical field of separation, enrichment and analysis and detection. 2. Background technology

[0002] Benzodiazepines These drugs have sedative, hypnotic, and central skeletal muscle relaxation effects. The clinical manifestations of acute poisoning of the drug are mainly in the muscles and central nervous system, such as muscle weakness, hypotonia, ataxia, dysphonia, lethargy and other symptoms, and severe poisoning manifests as coma, mydriasis, and respira...

Claims

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