A lonicera and scutellaria drip pill and its preparation method

A technology of yellow dripping pills and dripping pills, which is applied in the field of medicines, Yinhuang dripping pills and their preparation, can solve the problems of long disintegration time limit, slowing down the release speed of active ingredients, and poor dissolution in vitro, so as to facilitate dissolution and fully The effects of absorption, flexible and accurate dosage, and stable drug quality

Inactive Publication Date: 2007-08-01
况海滨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned preparations are traditional Chinese medicine preparations, which have defects such as slow effect, large dosage, long treatment time, low bioavailability, relatively unstable quality, and inconvenient use:
[0003] 1. Poor dissolution in vitro and slow onset
In the prior art, the honeysuckle and astragalus extracts in Yinhuang Tablets, Yinhuang Capsules, and Yinhuang Granules contain a large number of insoluble and highly hydrophobic active ingredients. These active ingredients themselves are not easy to dissolve, and a large amount of sucrose and Other excipients are molded, not easy to disintegrate, the in vitro dissolution is very poor, and the disintegration time is long. ), which further slows down the release rate of the above-mentioned active ingredients; therefore, in clinical practice, Yinhuang Tablets, Yinhuang Capsules, Yinhuang Granules, etc. have slow onset of effects, and generally need to be taken several times a day in large quantities for a few days before they appear more obvious Efficacy
[0004] 2. Poor effective absorption and low bioavailability
[0008] 6. In addition, the granulation...

Method used

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  • A lonicera and scutellaria drip pill and its preparation method
  • A lonicera and scutellaria drip pill and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: prepare Yinhuang dripping pills

[0038] by WS 3 -B-1233-92 Prepare 10g of honeysuckle extract and 4g of Scutellaria baicalensis extract, crush them through a 100-mesh sieve, and set aside, take 46g of polyethylene glycol 4000, heat and melt in a water bath at 80°C, add honeysuckle extract and Scutellaria baicalensis extract under stirring Stir at 80°C for 1 hour to disperse evenly, and transfer the liquid medicine to the 80°C constant temperature storage tank of the dropping pill machine. Methyl silicone oil, under the condition of cooling liquid temperature 20 ± 3 ℃, adjust the weight of dropping pills to 60mg, drop into pills, remove the cooling liquid on the surface of dropping pills, pack separately, and obtain 14 mg of silvery yellow extract (honeysuckle extract 10mg: Scutellaria baicalensis extract 4mg) and polyethylene glycol 4000 46mg Yinhuang drop pills.

experiment example 1

[0040] Experimental Example 1: The applicant explored and screened out a reasonable process for preparing Yinhuang dripping pills through a large number of experiments.

[0041] (1) Excipient screening:

[0042] Dropping pill bases include water-soluble bases and water-insoluble bases, commonly used polyethylene glycols (such as polyethylene glycol 6000, polyethylene glycol 4000, etc.), poloxamer, polyoxyl stearate (40 ) ester (S-40), gelatin, stearic acid, glyceryl monostearate, hydrogenated vegetable oil, etc. The condensate of dripping pills must be safe and harmless, and have no effect on the main drug. The commonly used ones are liquid paraffin, vegetable oil, methyl silicone oil and water. Polyethylene glycol is a commonly used solid dispersion matrix for dropping pills. It has stable properties and is not easy to chemically react with drugs. Therefore, we prefer polyethylene glycol as the dispersion matrix. On the basis of the maximum drug loading, the fluidity of the...

experiment example 2

[0055] Experimental Example 2: Recipe Optimization

[0056] From the above orthogonal test results, it can be seen that the current optimal prescription process is not perfect, and the fluidity of the liquid medicine is not very good. In order to make the preparation process prescription of this product more reasonable, the preparation process is more suitable for industrial production, so on the basis of the above orthogonal test results On the basis of further optimization of the current best process prescription, the fluidity of the liquid medicine can be improved by adding an appropriate amount of regulators. The investigation methods are shown in Table 4.

[0057] Inspection method:

[0058] With the temperature of the liquid medicine at 80°C and simethicone oil as the coolant, prepare the liquid medicine according to the prescription in Table 4, stir for 40 minutes under heat preservation, and let stand for 2 hours under heat preservation to investigate the fluidity and ...

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Abstract

The invention relates to a Yinhuang dripping pill and its preparing process, wherein the pill has the advantages of quick action, stabilized quality and low cost.

Description

Technical field: [0001] The invention relates to a Yinhuang dripping pill and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique: [0002] At present, there are silver yellow tablets (WS 3 -B-1233-92), Silver Capsules (WS 3 -B-36), Yinhuang Granules (WS 3 -B-1234-94), Yinhuang Injection (WS 3 -B-36) etc., are widely used in the treatment of acute and chronic tonsillitis, upper respiratory tract infection, etc., and receive a good therapeutic effect. Wherein the above-mentioned silver yellow oral preparation is made of extracts of honeysuckle and scutellaria baicalensis, and the prescription composition is honeysuckle extract: scutellaria baicalensis extract=100:40. The above-mentioned preparations are traditional Chinese medicine preparations, which have defects such as slow effect, large dosage, long treatment time, low bioavailability, relatively unstable quality, and inconvenient use: [0003] 1. Poor dissolution i...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/20A61P11/04
Inventor 任召言马成俊李敏
Owner 况海滨
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