A lonicera and scutellaria drip pill and its preparation method

Abstract

The invention relates to a Yinhuang dripping pill and its preparing process, wherein the pill has the advantages of quick action, stabilized quality and low cost.

Description

Technical field: [0001] The invention relates to a Yinhuang dripping pill and a preparation method thereof, belonging to the field of pharmaceutical technology. Background technique: [0002] At present, there are silver yellow tablets (WS 3 -B-1233-92), Silver Capsules (WS 3 -B-36), Yinhuang Granules (WS 3 -B-1234-94), Yinhuang Injection (WS 3 -B-36) etc., are widely used in the treatment of acute and chronic tonsillitis, upper respiratory tract infection, etc., and receive a good therapeutic effect. Wherein the above-mentioned silver yellow oral preparation is made of extracts of honeysuckle and scutellaria baicalensis, and the prescription composition is honeysuckle extract: scutellaria baicalensis extract=100:40. The above-mentioned preparations are traditional Chinese medicine preparations, which have defects such as slow effect, large dosage, long treatment time, low bioavailability, relatively unstable quality, and inconvenient use: [0003] 1. Poor dissolution i...

AI Technical Summary

Problems solved by technology

The above-mentioned preparations are traditional Chinese medicine preparations, which have defects such as slow effect, large dosage, long treatment time, low bioavailability, relatively unstable quality, and inconvenient use:

[0003] 1. Poor dissolution in vitro and slow onset

In the prior art, the honeysuckle and astragalus extracts in Yinhuang Tablets, Yinhuang Capsules, and Yinhuang Granules contain a large number of insoluble and highly hydrophobic active ingredients. These active ingredients themselves are not easy to dissolve, and a large amount of sucrose and Other excipients are molded, not easy to disintegrate, the in vitro dissolution is very poor, and the disintegration time is long. ), which further slows down the release rate of the above-mentioned active ingredients; therefore, in clinical practice, Yinhuang Tablets, Yinhuang Capsules, Yinhuang Granules, etc. have slow onset of effects, and generally need to be taken several times a day in large quantities for a few days before they appear more obvious Efficacy

[0004] 2. Poor effective absorption and low bioavailability

[0008] 6. In addition, the granulation process during the preparation of Yinhuang Tablets, Yinhuang Capsules, and Yinhuang Granules will produce relatively large dust pollution, which will cause harm to the health of the staff to a certain extent, and will also cause certain pollution to the environment

[0009] 7. Yinhuang Tablets, Yinhuang Capsules, Yinhuang Granules, and Yinhuang Injections have many production processes and high production costs, which will increase the cost of medication for patients, which is not conducive to improving the overall health of the society

[0013] However, due to the dispersibility of the drop pill preparation process conditions, the silver yellow prescription containing more thermally unstable and volatile active ingredients still has problems such as: how to avoid volatile ingredients in the process of preparing drop pills. loss, what kind of process conditions can prevent the loss of thermally unstable components, how to reasonably disperse the active ingredients, and what kind of process conditions can obtain the highest pelleting rate and rounding rate, etc., so far there is no Any Yinhuang Dropping Pills available on the market

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