Multifunctional ion liquid system, preparation and application thereof

Abstract

The invention relates to a complex function ion liquid system, producing method and the application thereof belonging to new material and refinery chemical field. The complex function ion liquid system is composed of phosphine ligand functional ion liquid and alkali functional ion liquid, in which the phosphine ligand functional ion liquid is to link the traditional phosphine ligand to the typical ion liquid with an introducing position on the cation segment or the anion segment of the ion liquid. The cation ion and anion ion parts of the alkalescence functional ion liquid may have the alkaline group respectively or simultaneously. The provided complex function ion liquid can be applied in the coupling reaction of C-C / C-N. The advantages is that: complex function ion liquid system simultaneously plays a role of ligand, attaching acid agent and solvent and puts up an integrated cooperative catalytic effect; and it can be reused for several times and avoids using the poisonous, harmful and volatile organic solvent.

Description

Technical field [0001] The invention relates to a type of composite functional ionic liquid system and a preparation method thereof, and its application in carbon-carbon and carbon-nitrogen coupling reactions catalyzed by palladium, belonging to the field of new materials and fine chemicals. Background technique [0002] The carbon-carbon and carbon-nitrogen coupling reactions carried out under the action of transition metal palladium compound catalysts occupy an important position in organic synthetic chemistry. It is one of the effective methods for the preparation of many fine chemicals and pharmaceutical intermediates, and can be applied to medicines. , Pesticides, dyes, daily chemicals and polymers. However, the shortcomings of this reaction include the following aspects: ①The catalyst system is unstable. After a fresh catalyst is used once, palladium black is often precipitated—the catalyst is deactivated; ②The use of phosphine ligands—usually due ...

AI Technical Summary

Problems solved by technology

However, the disadvantages of this reaction are as follows: 1. The catalyst system is unstable. After a fresh catalyst is used once, it often precipitates palladium black—catalyst deactivation; Expensive phosphine ligands to maintain the stability and activity of palladium catalysts

But the phosphine ligand is easy to oxidize and decompose and deteriorate (sensitive to water and air); 3. The use of alkali-using organic base or inorganic base as acid-binding agent, forming a large amount of by-product sodium salt, potassium salt or ammonium salt, these by-product salts The accumulation of metal palladium catalysts will gradually be poisoned and deactivated, which limits the reuse of catalysts; these by-product solid salts are mixed with organic products to form a paste, which brings difficulties to product separation; inorganic bases in organic solvents and reactants The solubility in the medium is very poor, and its acid-binding effect is affected by the limitation of mass transfer, thus limiting the coupling reaction rate and efficiency

④The use of toxic and harmful organic solvents not only pollutes the environment, but also makes the separation and purification of subsequent products cumbersome; ⑤The residues of toxic metal palladium and phosphine ligands in organic products limit the use of products in the fields of medicine and food

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