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Esterified object of maleic anhydride of styrene, preparation method, and application

A technology of styrene maleic acid and maleic anhydride, which can be used in drug delivery, pharmaceutical formulation and other directions, and can solve the problems of long reaction time, low esterification rate, and many by-products.

Inactive Publication Date: 2007-10-10
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Description
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Problems solved by technology

This method also has relatively large disadvantages. The use of acidic catalysts makes the esterification rate not high, the reaction time is long, and there are many by-products.

Method used

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  • Esterified object of maleic anhydride of styrene, preparation method, and application
  • Esterified object of maleic anhydride of styrene, preparation method, and application

Examples

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Embodiment Construction

[0017] Examples (in list form)

[0018] a. First select two reactants, one with The structure of reactants, where R 1 is phenyl or methyl carboxylate or cyano or hydrogen or methyl or carboxyl, R 2 is hydrogen or methyl; another monoalcohol reactant is methanol or ethanol or n-propanol or isopropanol or n-pentanol or isobutanol or n-pentanol or ethyl octanol or polyethylene glycol monomethyl ether or Polyethylene glycol monoethyl ether or polyethylene glycol monobutyl ether;

[0019] B, these two kinds of reactants are placed in solvent acetone or butanone or tetrahydrofuran or dimethyl sulfoxide or N, N-dimethylformamide or N, N-dimethylacetamide or toluene or benzene to react, then The mass ratio of the reactants is 0.001%-30% of the catalyst pyridine or trimethylamine or triethylamine or aniline or N,N dimethylaniline or ethylenediamine or 4-dimethylaminopyridine or sodium ethoxide or sodium hydroxide Or potassium hydroxide or sodium tert-butoxide or potassium tert-but...

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Abstract

This invention relates to a method for preparing styrene-maleic anhydride esterification product. The method comprises: dissolving styrene-maleic anhydride copolymer in solvent, adding alcohol, adding basic catalyst, reacting, purifying the product, and refining. The product can be used as controlled release agent aid for pH-sensitive drugs, paint dispersant, high-efficiency water-reducing agent, polyelectrolyte and phase-separating material.

Description

technical field [0001] The invention relates to styrene maleic anhydride esters and their preparation methods and applications in the field of biomedicine, mainly used as auxiliary materials for slow and controlled release drugs, dispersants for pigments, high-efficiency water reducers, polymer dielectrics, and according to the pH value of the environment and temperature changes to prepare phase-separated materials, etc. Background technique [0002] Styrene maleic anhydride ester is a widely used and inexpensive material, and it contains an acid anhydride, a highly active functional group, which can be changed to change its physical and chemical properties to obtain an ideal material. In this regard, many scholars at home and abroad have conducted a lot of research and obtained many new materials. For example, "A Synthesis Technology for Controlled Release of Drug Carriers (Patent No. 02101964.9)" and "Drug Coating Preparation of Polymer Materials Released...

Claims

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Application Information

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IPC IPC(8): C08F8/14C08F212/08A61K9/22
Inventor 曹贞虎高林田华赖小林赵文军孙成栋
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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