Esterified object of maleic anhydride of styrene, preparation method, and application

A technology of styrene maleic acid and maleic anhydride, which can be used in drug delivery, pharmaceutical formulation and other directions, and can solve the problems of long reaction time, low esterification rate, and many by-products.

Inactive Publication Date: 2007-10-10
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
View PDF2 Cites 16 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method also has relatively large disadvantages. The use of acidic catalysts makes th

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Esterified object of maleic anhydride of styrene, preparation method, and application
  • Esterified object of maleic anhydride of styrene, preparation method, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] Examples (in list form)

[0018] a. First select two reactants, one with The structure of reactants, where R 1 is phenyl or methyl carboxylate or cyano or hydrogen or methyl or carboxyl, R 2 is hydrogen or methyl; another monoalcohol reactant is methanol or ethanol or n-propanol or isopropanol or n-pentanol or isobutanol or n-pentanol or ethyl octanol or polyethylene glycol monomethyl ether or Polyethylene glycol monoethyl ether or polyethylene glycol monobutyl ether;

[0019] B, these two kinds of reactants are placed in solvent acetone or butanone or tetrahydrofuran or dimethyl sulfoxide or N, N-dimethylformamide or N, N-dimethylacetamide or toluene or benzene to react, then The mass ratio of the reactants is 0.001%-30% of the catalyst pyridine or trimethylamine or triethylamine or aniline or N,N dimethylaniline or ethylenediamine or 4-dimethylaminopyridine or sodium ethoxide or sodium hydroxide Or potassium hydroxide or sodium tert-butoxide or potassium tert-but...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

This invention relates to a method for preparing styrene-maleic anhydride esterification product. The method comprises: dissolving styrene-maleic anhydride copolymer in solvent, adding alcohol, adding basic catalyst, reacting, purifying the product, and refining. The product can be used as controlled release agent aid for pH-sensitive drugs, paint dispersant, high-efficiency water-reducing agent, polyelectrolyte and phase-separating material.

Description

technical field [0001] The invention relates to styrene maleic anhydride esters and their preparation methods and applications in the field of biomedicine, mainly used as auxiliary materials for slow and controlled release drugs, dispersants for pigments, high-efficiency water reducers, polymer dielectrics, and according to the pH value of the environment and temperature changes to prepare phase-separated materials, etc. Background technique [0002] Styrene maleic anhydride ester is a widely used and inexpensive material, and it contains an acid anhydride, a highly active functional group, which can be changed to change its physical and chemical properties to obtain an ideal material. In this regard, many scholars at home and abroad have conducted a lot of research and obtained many new materials. For example, "A Synthesis Technology for Controlled Release of Drug Carriers (Patent No. 02101964.9)" and "Drug Coating Preparation of Polymer Materials Released...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08F8/14C08F212/08A61K9/22
Inventor 曹贞虎高林田华赖小林赵文军孙成栋
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap