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Method of preparing temperature sensitive nano microcapsule by using small molecule hydrocarbon as template

A technology of nano-microcapsules and small molecular hydrocarbons, applied in microcapsule preparation, microsphere preparation, etc., can solve the problems of limited application scope, difficult removal of polymer templates, and easy flocculation of polyelectrolyte particles.

Inactive Publication Date: 2007-12-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] For method (1), it is necessary to use living radical polymerization to synthesize block polymers first, then self-assemble, use hydrolysis-condensation reactions to form inorganic phases, and then remove hydrophobic polymer cores. There are relatively many steps and there is an assembly efficiency. Limited problems; for method (2), the layer-by-layer self-assembly of polyelectrolytes also requires the step of removing the template, and because polyelectrolyte particles are easy to flocculate, they need to be carried out at extremely low concentrations, and cannot be stably dispersed in solvents, so Its scope of application is also limited; for method (3), although the synthesis is easier, it is relatively difficult for the removal of the polymer template, and the separation of the removed polymer and microcapsules is also troublesome; for method (4), the preparation The process is the most convenient, and microcapsules can be obtained in only one step reaction, and the removal of small molecule hydrocarbon templates is convenient, so it is a good method for preparing microcapsules
The present invention will prepare temperature-sensitive nano-microcapsules on the basis of this method, and there is no report on synthesizing temperature-sensitive nano-microcapsules by this method

Method used

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  • Method of preparing temperature sensitive nano microcapsule by using small molecule hydrocarbon as template
  • Method of preparing temperature sensitive nano microcapsule by using small molecule hydrocarbon as template
  • Method of preparing temperature sensitive nano microcapsule by using small molecule hydrocarbon as template

Examples

Experimental program
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Effect test

Embodiment 1

[0057] Weigh 0.53 g of emulsifier sodium dodecylsulfonate and add it to 1000 g of water to obtain an emulsifier solution. Mix 10g of octane, 0.6g of hexadecane, 0.3g of N-isopropylacrylamide, 2g of styrene, and 0.5g of divinylbenzene, add them to the above emulsifier aqueous solution, and disperse the above mixed solution with ultrasonic waves to obtain Stable emulsion; the temperature was adjusted to 80°C, and under the protection of nitrogen, 0.25 g of potassium persulfate was added to initiate the reaction for 120 minutes. The particle size is measured with a dynamic light scattering particle size analyzer: at 25°C, its hydrodynamic diameter is 106.5nm; at 40°C, its hydrodynamic diameter is 102.4nm, and the particles are basically insensitive to temperature. Observing its morphology with a transmission electron microscope, it is a capsule with a hollow structure. Add 0.05 g of potassium persulfate, add dropwise an aqueous solution prepared by 4.5 g of N-isopropylacrylamide...

Embodiment 2

[0059] Weigh 8 g of emulsifier cetyltrimethylammonium bromide and add it into 1000 g of water to obtain an emulsifier solution. Mix 200g of octane, 12g of hexadecane, 6g of vinyl caprolactam, 60g of styrene, and 40g of divinylbenzene, add them to the above-mentioned emulsifier aqueous solution, and disperse the above-mentioned mixed solution with ultrasonic waves to obtain a stable emulsion; adjust the temperature to At 60°C, under nitrogen protection, 5 g of 2,2'-azo(2-amidinopropane) dihydrochloride was added to initiate the reaction for 240 minutes. The particle size is measured with a dynamic light scattering particle size analyzer: at 25°C, its hydrodynamic diameter is 134.2nm; at 40°C, its hydrodynamic diameter is 129.5nm, and the particles are basically insensitive to temperature. Observing its morphology with a transmission electron microscope, it is a capsule with a hollow structure. Add 0.1 g of potassium persulfate, add dropwise the aqueous solution prepared by 12 ...

Embodiment 3

[0061]Weigh 70g of emulsifier OP-10 and add it into 1000g of water to obtain emulsifier solution. Mix 200g of pentane, 50g of cetyl alcohol, 12g of vinyl isobutyramide, 440g of styrene, and 4.6g of N,N'-methylenebisacrylamide, add them to the above-mentioned emulsifier-containing aqueous solution, and ultrasonically shake the above-mentioned The mixed solution was dispersed to obtain a stable emulsion; the temperature was adjusted to 50°C, and under the protection of nitrogen, 10 g of potassium persulfate and 5 g of sodium sulfite were added to initiate the reaction for 260 min. The particle size is measured with a dynamic light scattering particle size analyzer: at 25°C, its hydrodynamic diameter is 150.3nm; at 40°C, its hydrodynamic diameter is 147.6nm, and the particles are basically insensitive to temperature. Observing its morphology with a transmission electron microscope, it is a capsule with a hollow structure. Add 5g of potassium persulfate, 2.5g of ethylamine, dropw...

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Abstract

The invention relates to the making of nanometer microcapsule. It uses organic small mole hydrocarbon drop as the template, using fine lotion polymer, polymerizing the temperature sensitive monomer, polymer monomer and coupling monomer, using the coupling monomer to form into coupling shell, dropping with extra monomers of the above to form into temperature sensitive nanometer capsule. It is simple, effective, stable to get 100-100 nanometer temperature sensitive capsule, being able to adjust the size of he capsule through adjusting the environmental temperature, further controlling the loading and release. It can be used as the catalyst loading, protein and other active matter control and release.

Description

technical field [0001] The invention relates to a method for preparing nanometer microcapsules, in particular to a method for preparing temperature-sensitive nanometer microcapsules by using small molecule hydrocarbons as templates. Background technique [0002] Thermosensitive polymers respond intelligently and reversibly to environmental changes, especially temperature changes. Therefore, since the discovery of the temperature-sensitive properties of linear poly-N-isopropylacrylamide in 1969 (Heskins M, Guillet J E.J Macromol Sci Chem, 1969, 2: 1441), research on this type of polymer has always been a major issue in polymer science. One of the hotspots in the field. The phase transition phenomenon that thermosensitive polymers can exhibit near the lowest critical solution temperature (LCST), it is generally believed that the reason for the phase transition phenomenon of thermosensitive polymers is due to the thermosensitive polymerization above the lowest critical phase t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/14
Inventor 单国荣曹志海
Owner ZHEJIANG UNIV