(1Z, 4Z, 5Z) ¿C 6 N alkyl ¿C 6 ¿C aza ¿C2 ¿C oxo ¿C 3 ¿C oxa ¿C 4 ¿C methoxy ¿C dicyclo [3, 1, 0] hexane and preparation method
An aziridine and methoxy technology, applied in (1Z,4Z,5Z)-6-N-alkyl-6-aza-2-oxo-3-oxa-4-methoxy - Bicyclo[3.1.0]hexane and its preparation and application fields, can solve the problems of low yield and no anticancer activity, and achieve the effects of reducing cost, improving yield and simplifying experimental operation
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Embodiment 1
[0036] The synthesis of embodiment 1, hydroxybutene lactone (compound 2)
[0037] Dissolve 236g (2.46mol) of freshly steamed furfural (compound 1) in 2300mL of 95% ethanol, add 2g of rose bengal (Rose Bengal) as a photosensitizer, pass in oxygen, irradiate with a 1000W iodine tungsten lamp, and keep the temperature at 23-27 ℃, magnetic stirring, TLC (thin layer chromatography) tracking reaction, the reaction takes about 40h; after the reaction is stopped, the ethanol is evaporated on a rotary evaporator to obtain a wine-red thick liquid, and a yellow solid is precipitated after freezing, which is quickly filtered by suction , dried to give a light yellow solid; recrystallized from petroleum ether to obtain hydroxybutenolactone (compound 2), 158 g of white needle-like crystals, yield 64%, m.p.54-55°C.
Embodiment 2
[0038] The synthesis of embodiment 2,5-methoxyl group-2(5H)-furanone (compound 3)
[0039] Dissolve 20g (200mmol) of hydroxybutene lactone (compound 2) in 80mL of methanol, heat to reflux in an oil bath (about 72h), and track the reaction by TLC; after the reaction, remove methanol by rotary evaporation on a rotary evaporator to obtain crude product ; Distillation under reduced pressure or flash column chromatography (petroleum ether / acetone=20:1) to obtain 5-methoxy-2(5H)-furanone (compound 3), colorless liquid, 16g, yield 70%.
Embodiment 3
[0040] Embodiment 3, the synthesis of 5-methoxy-3-bromo-2 (5H)-furanone (compound 4)
[0041] Dissolve 16g (140.4mmol) of 5-methoxy-2(5H)-furanone (compound 3) in 140mL of benzene, then slowly add Br 2 , stir evenly at room temperature, cool the ice-water bath to 0°C, and slowly add pyridine dropwise. After the addition, remove the ice-water bath, stir at room temperature, and react for about 1.5 hours; Dissolve, separate the organic layer, wash with saturated brine, then add anhydrous magnesium sulfate to dry; filter, evaporate the solvent under reduced pressure to obtain the crude product by vacuum distillation or flash column chromatography (petroleum ether / acetone=20:1) , to obtain 5-methoxy-3-bromo-2(5H)-furanone (compound 4), light yellow liquid, 20 g, yield 73.8%.
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