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Microwave assisted molecular blotting magnetic microsphere preparation method and uses

A technology of magnetic microspheres and molecular imprinting, applied in the fields of material science and engineering and modern separation analysis, to achieve the effect of improving uniformity and stability, good dispersion, and shortening aging time

Inactive Publication Date: 2008-01-09
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the limitations of the above-mentioned molecularly imprinted polymers in terms of time-consuming and poor uniformity in the preparation process, as well as the shortcomings in the selectivity, stability and repeatability in the application process, the purpose of the present invention is to provide a microwave-assisted The preparation method of molecularly imprinted magnetic microspheres adopts temperature-controllable microwave heating instead of traditional heating method to prepare Fe 3 o 4 Magnetic particles and poly(acrylic acid-styrene) molecularly imprinted magnetic microspheres to realize the controllable particle size of MIP magnetic microspheres and improve their uniformity and stability

Method used

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  • Microwave assisted molecular blotting magnetic microsphere preparation method and uses
  • Microwave assisted molecular blotting magnetic microsphere preparation method and uses
  • Microwave assisted molecular blotting magnetic microsphere preparation method and uses

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preparation example Construction

[0025] The invention is a preparation method of microwave-assisted molecularly imprinted magnetic microspheres, comprising the following steps:

[0026] 1).Microwave heating chemical precipitation method to synthesize nano-Fe 3 o 4 Magnetic fluid, ultrasonic cleaning, magnetic field separation, magnetic fluid cleaning to neutral, redispersed in water;

[0027] 2). Mix the template molecules and functional monomers and shake them well, and place them at room temperature for 10-14 hours; add a crosslinking agent to the mixed solution, shake them well, and leave them at room temperature for 10-14 hours.

[0028] 3). The Fe obtained in step (1) 3 o 4 The magnetic fluid is stirred and mixed with water, anionic surfactant and stabilizer, and the ultrasonic dispersion time is not less than 30 minutes;

[0029] 4). Add the polymerization solvent and the magnetic fluid dispersed in the anionic surfactant and stabilizer in the step (3) to the reaction bottle in the microwave reactor...

Embodiment

[0039] This embodiment takes atrazine as an example to describe the present invention in detail, but this does not limit the protection scope of the present invention.

[0040] As shown in Figure 1, the preparation method of atrazine molecularly imprinted magnetic microspheres is as follows:

[0041] (1) Using a microwave chemical reactor, the microwave output power is continuously adjustable. Install a reaction flask with a mechanical stirrer (polytetrafluoroethylene stirring rod), a condenser tube, a liquid inlet and a vent in the microwave reactor, and add 20 mL of Fe 3+ : Fe 2+ A 2:1 mixed solution in 120mL distilled water, N 2 After 20 minutes, under 600r / min mechanical stirring, quickly add 28% NH with a balanced addition funnel 3 ·H 2 O.

[0042] (2) Preparation of nano-Fe 3 o 4 The reaction of the ferrofluid occurs until the end of aging, and the continuous feeding of N 2 Deoxygenate and maintain a stirring speed of 580-600r / min with high-speed mechanical stir...

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Abstract

The invention belongs to the field of modern isolation analysis materials science and engineering, it relates to preparation method and application of microwave assistant molecular print magnetic microsphere, the procedure as follows: adopting microwave chemical reactor, taking nanometer magnetic fluid as magnetic nuclei, by cleaning and external modification, ultrasound detracting to water; mounted pattern molecule and functional monomer self-assembly; adding polymeric liquor by step, cross link agent and initiator, making it mixes and separates with magnetic fluid fully by stirring of machine, microwave procedure controlled temperature and heats up, until raising polymerization; Magnetic separates the foregoing magnetic microsphere, removing mounted pattern molecule, vacuum drying, aging. The molecular print magnetic microsphere has not only recognize ability of mounted pattern molecule and its analogue, but also has the approved characteristic of 'gathering hyphen recycle', the process of preparation heats up with microwave, decreasing the time of print aggregation, improving homogeneity and print efficiency of polymer form. The molecular print magnetic sphere applies to gather, isolate and analysis of structure analogue in the environmental sample, eatable etc complex samples.

Description

technical field [0001] The invention belongs to the field of material science and engineering and modern separation analysis, and relates to a preparation method of microwave-assisted molecularly imprinted magnetic microspheres. It is suitable for the separation and enrichment of imprinted molecules and structurally similar compounds in complex samples such as biology, medicine, environmental samples and food. Background technique [0002] In recent years, with the deepening of research on molecular imprinting technology and the expansion of application fields, the preparation technology and performance research of molecularly imprinted polymers (MIP) have been widely concerned and highly valued by scholars from all over the world. However, the preparation method of MIP is still based on bulk polymerization and solution polymerization, and the obtained product is usually block. Although the polymerization process is simple, the follow-up processing is cumbersome and time-con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N1/34
Inventor 李攻科张毅胡玉玲
Owner SUN YAT SEN UNIV
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