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Iron supplement composition, its preparing method and application of the same

A technology of composition and iron supplement, which is applied in the direction of drug combination, pill delivery, metabolic diseases, etc., can solve the problems of gastrointestinal mucosa irritation, low bioavailability, abdominal pain and constipation, etc., so as to reduce the dosage of drugs and solve the problem of Stimulating, good nutritional potency effect

Pending Publication Date: 2008-02-27
内蒙古百金纳投资有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There are two common problems in the currently used iron supplements: 1) iron is poorly absorbed in the gastrointestinal tract and has low bioavailability; 2) iron is irritating to the gastrointestinal mucosa, which can cause nausea, vomiting, abdominal pain and constipation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: preparation tablet

[0042] Composition of the composition:

[0043] Ferrous Glycinate 75g

[0044] Vitamin C 5g

[0045] Magnesium Stearate 2g

[0046] Microcrystalline Cellulose MCC (PH102) 118g

[0047] Crospovidone 40g

[0048] Makes 1000 pieces

[0049]

[0050] Preparation Process:

[0051] After the above-mentioned raw and auxiliary materials that are commercially available and meet the pharmaceutical standards pass the inspection, the above-mentioned main drug and each auxiliary material are weighed according to the above-mentioned formula. Firstly, ferrous glycinate and microcrystalline cellulose are fully mixed and evenly passed through a 100-mesh sieve.

[0052] Magnesium stearate, crospovidone, and vitamin C are mixed, ground, and passed through a 100-mesh sieve. It is then mixed with microcrystalline cellulose and ferrous glycinate powder and then compressed into tablets.

Embodiment 2

[0053] Embodiment 2: preparation tablet

[0054] The mixed antioxidant of vitamin C, vitamin E and citric acid is more beneficial to the antioxidant effect and can promote the absorption of iron supplements.

[0055] The composition of present embodiment composition is:

[0056] Ferrous Glycinate 75g

[0057] Vitamin C 2g

[0058] Vitamin E 2g

[0059] Citric acid 2g

[0060] Magnesium Stearate 1g

[0061] Microcrystalline Cellulose MCC (PH102) 108g

[0062] Crospovidone 20g

[0063] Cyclodextrin 20g

[0064] Sodium Carboxymethyl Cellulose 10g

[0065]

[0066] Makes 1000 pieces

[0067] Preparation process: Weigh an appropriate amount of raw and auxiliary materials according to the above composition, and pass through a 100-mesh sieve for later use. First, vitamin C, vitamin E, and citric acid are milled, mixed and sieved; magnesium stearate is milled, mixed and sieved with cyclodextrin and sodium carboxymethylcellulose,...

Embodiment 3

[0068] Embodiment 3: preparation tablet

[0069] The composition of the composition is:

[0070] Ferrous Glycinate 75g

[0071] Vitamin C 2g

[0072] Beta Carotene 2g

[0073] Citric acid 1g

[0074] fructooligosaccharide 10g

[0075] Magnesium Stearate 1g

[0076] Microcrystalline Cellulose MCC (PH102) 99g

[0077] Cyclodextrin 30g

[0078] Sodium Carboxymethyl Cellulose 20g

[0079]

[0080] Makes 1000 pieces

[0081] Preparation process: Weigh an appropriate amount of raw and auxiliary materials according to the above prescription, and pass through a 100-mesh sieve for later use. First, vitamin C, vitamin E, and citric acid are milled and mixed, and then mixed with cyclodextrin, sorbitol, sodium carboxymethyl cellulose, and microcrystalline cellulose, and the rest are the same as in Example 1 to prepare tablets.

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PUM

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Abstract

The invention discloses a pharmaceutical composition as an iron supplement agent, which comprises ferrous glycinate, antioxidant and medicinal carrying agents. The invention also discloses preparations containing the composition, the process for preparing the composition and the preparations, and the use of the composition in preventing and treating iron deficiency. The composition is capable of appreciably improving the absorption ratio of iron in intestinal tract, thereby improving iron-deficiency anemia effectively.

Description

technical field [0001] The invention relates to a pharmaceutical composition with iron supplementation function, a preparation method thereof, and pharmaceutical preparations, health care products or food containing the composition. The composition is used for the prevention and treatment of iron deficiency. Specifically, the composition contains ferrous glycinate as an active ingredient. Background technique [0002] Iron is one of the essential trace elements for the human body. It is an indispensable substance in many physiological processes of the human body, and it is also the core part of hemoglobin. People's iron requirements vary with age and physiological conditions. According to the dietary nutrient reference intake regulations of Chinese residents formulated by the Chinese Nutrition Society, the daily recommended intake of iron is 12mg / day for 1-10 years old, 15-20mg / day for men aged 11-18, and 18-20mg / day for women. 25mg / day, 15mg / day for people aged 18-50. 15...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/20A61K47/38A61P3/02
Inventor 孙卫许学书谢静莉吴炜锋顾志敏
Owner 内蒙古百金纳投资有限责任公司
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